Simvastatin loaded chitosan guided bone regeneration membranes stimulate bone healing

2021 ◽  
Author(s):  
Vishnu Priya Murali ◽  
Fernanda D. Guerra ◽  
Najib Ghadri ◽  
James M. Christian ◽  
Sidney H. Stein ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Healing ◽  
Guided Bone Regeneration

scholarly journals Zn-Containing Membranes for Guided Bone Regeneration in Dentistry

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1797
Author(s):  
Manuel Toledano ◽  
Marta Vallecillo-Rivas ◽  
María T. Osorio ◽  
Esther Muñoz-Soto ◽  
Manuel Toledano-Osorio ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Bone Healing ◽  
Bone Repair ◽  
Complex Modulus ◽  
Bacterial Colonization ◽  
Guided Bone Regeneration ◽  
M2 Macrophage

Barrier membranes are employed in guided bone regeneration (GBR) to facilitate bone in-growth. A bioactive and biomimetic Zn-doped membrane with the ability to participate in bone healing and regeneration is necessary. The aim of the present study is to state the effect of doping the membranes for GBR with zinc compounds in the improvement of bone regeneration. A literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI, Embase, Scopus and Web of Science. A narrative exploratory review was undertaken, focusing on the antibacterial effects, physicochemical and biological properties of Zn-loaded membranes. Bioactivity, bone formation and cytotoxicity were analyzed. Microstructure and mechanical properties of these membranes were also determined. Zn-doped membranes have inhibited in vivo and in vitro bacterial colonization. Zn-alloy and Zn-doped membranes attained good biocompatibility and were found to be non-toxic to cells. The Zn-doped matrices showed feasible mechanical properties, such as flexibility, strength, complex modulus and tan delta. Zn incorporation in polymeric membranes provided the highest regenerative efficiency for bone healing in experimental animals, potentiating osteogenesis, angiogenesis, biological activity and a balanced remodeling. Zn-loaded membranes doped with SiO2 nanoparticles have performed as bioactive modulators provoking an M2 macrophage increase and are a potential biomaterial for promoting bone repair. Zn-doped membranes have promoted pro-healing phenotypes.

Use of Beta-tricalcium Phosphate Bone Graft with Collagen Membrane as Guided Bone Regeneration in Long Bone Fractures with Bone Loss in Dogs: A Clinical Study

2020 ◽  
Author(s):  
K. Preethi ◽  
V. Gireesh Kumar ◽  
K.B.P. Raghavender ◽  
D. Pramod Kumar ◽  
M. Lakshman
Keyword(s):  
Bone Loss ◽  
Bone Graft ◽  
Bone Regeneration ◽  
Bone Healing ◽  
Bone Fractures ◽  
Guided Bone Regeneration ◽  
Long Bone ◽  
Collagen Membrane ◽  
Beta Tricalcium Phosphate ◽  
Long Bone Fractures

Background: Fractures associated with bone loss requires stabilization with suitable fixation devices, placement of appropriate bone grafts to fill up the bone defects and barrier membranes as space maintainers for enhanced bone regeneration. The aim of this study was to evaluate the use of beta-tricalcium phosphate (β-TCP) bone graft with collagen membrane as guided bone regeneration in long bone fractures with bone loss in dogs. Method: Six dogs with long bone fractures accompanied with bone loss in Radius-ulna, Femur and Tibia were surgically treated with suitable bone plate as internal fixation with β-TCP bone graft along with collagen membrane placed at the fracture site. Conclusion: The application of β-TCP along with collagen membrane for filling the bone defect is extremely simple, convenient and less time consuming and proved to be effective in promoting early bone healing with rapid later phase bone healing and provided osteoconductive support and early resorption.

Infrared Laser Light Further Improves Bone Healing When Associated with Bone Morphogenetic Proteins and Guided Bone Regeneration: An in Vivo Study in a Rodent Model

2008 ◽  
Vol 26 (2) ◽  
pp. 167-174 ◽  
Author(s):  
Antonio Luiz B. Pinheiro ◽  
Marleny E. Martinez Gerbi ◽  
Elizabeth Arruda Carneiro Ponzi ◽  
Luciana Maria Pedreira Ramalho ◽  
Aparecida M.C. Marques ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Morphogenetic Proteins ◽  
Bone Healing ◽  
Laser Light ◽  
Guided Bone Regeneration ◽  
Infrared Laser ◽  
Rodent Model ◽  
In Vivo Study

Application of PRP gel alone or in combination with guided bone regeneration does not enhance bone healing process: An experimental study in rabbits

2011 ◽  
Vol 39 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Konstantinos Kazakos ◽  
Dimitrios Nikolaos Lyras ◽  
Vasilios Thomaidis ◽  
George Agrogiannis ◽  
Sotirios Botaitis ◽  
...  
Keyword(s):  
Experimental Study ◽  
Bone Regeneration ◽  
Bone Healing ◽  
Healing Process ◽  
Guided Bone Regeneration ◽  
Bone Healing Process ◽  
Prp Gel

Infrared Laser Light Further Improves Bone Healing When Associated with Bone Morphogenetic Proteins and Guided Bone Regeneration: Anin VivoStudy in a Rodent Model

2008 ◽  
Vol 0 (0) ◽  
pp. 080316101137023-8
Author(s):  
Antonio Luiz B. Pinheiro ◽  
Marleny E. Martinez Gerbi ◽  
Elizabeth Arruda Carneiro Ponzi ◽  
Luciana Maria Pedreira Ramalho ◽  
Aparecida M.C. Marques ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Morphogenetic Proteins ◽  
Bone Healing ◽  
Laser Light ◽  
Guided Bone Regeneration ◽  
Infrared Laser ◽  
Rodent Model

Guided Bone Regeneration (GBR) on Healing Bone Defects: A Histological Study in Rabbits

2004 ◽  
Vol 5 (2) ◽  
pp. 114-123 ◽  
Author(s):  
Muzaffer Asian ◽  
Göksel Şimşek ◽  
Ertunҫ Dayi
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Optical Microscopy ◽  
Bone Healing ◽  
Histological Study ◽  
Bone Defects ◽  
Guided Bone Regeneration ◽  
Control Group ◽  
Healing Bone ◽  
The Right

Abstract In this study, the effects of guided bone regeneration (GBR) on the healing of bone defects were evaluated. Resorbable membranes were placed in experimentally formed cavities in the right posterior tibia of 30 rabbits. Decalcified histological sections were evaluated using optical microscopy at 10, 20, and 30 days after GBR. Osteocondrial bone union, active bone formation and spongiosal bone formation values of the GBR group are higher than the control group. It was found that GBR technique had a positive and accelerating influence in all phases of bone healing. Citation Aslan M, Şimşek G, Dayi E. Guided Bone Regeneration (GBR) on Healing Bone Defects: A Histological Study in Rabbits. J Contemp Dent Pract 2004 May;(5)2:114-123.

SauFRa technique for the fixation of resorbable membranes in horizontal guided bone regeneration - a technical report

2020 ◽  
Author(s):  
Saurabh Mohan Kamat ◽  
Rakshit Khandeparker ◽  
Francis Akkara ◽  
Vikas Dhupar ◽  
Ashwin Mysore
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Novel Technique ◽  
Technical Report ◽  
Suturing Techniques ◽  
Graft Migration

Membrane fixation in guided bone regeneration (GBR) has been traditionally achieved using resorbable pins, titanium tacks or miniscrews. However, these techniques are marredwith a number of clinical challenges. This article presents the “SauFRa” technique, a novel technique for stabilization of resorbable membranes in both, single as well as multiple implant sites while avoiding the shortcomings of other suturing techniques described in literature. Furthermore, the technique also eliminates the possibility of complications observed when using resorbable pins, titanium tacks or miniscrews, such as damage to adjacent roots during insertion. The authors’ employed this technique in 89 patients (51 male and 35 female) and found no complications like tissue dehiscence, infection or graft migration.

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