scholarly journals R-spondin 2 promotes osteoblastic differentiation of immature human periodontal ligament cells through the Wnt/β-catenin signaling pathway

2018 ◽  
Vol 54 (2) ◽  
pp. 143-153 ◽  
Author(s):  
Mai Arima ◽  
Daigaku Hasegawa ◽  
Shinichiro Yoshida ◽  
Hiromi Mitarai ◽  
Atsushi Tomokiyo ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Periodontal Ligament ◽  
Osteoblastic Differentiation ◽  
Periodontal Ligament Cells ◽  
Human Periodontal Ligament Cells

scholarly journals Hypoxia-regulated human periodontal ligament cells via Wnt/β-catenin signaling pathway

Medicine ◽  
2017 ◽  
Vol 96 (16) ◽  
pp. e6562 ◽  
Author(s):  
Zhili Xiao ◽  
Yineng Han ◽  
Yan Zhang ◽  
Xiaonan Zhang
Keyword(s):  
Signaling Pathway ◽  
Periodontal Ligament ◽  
Periodontal Ligament Cells ◽  
Human Periodontal Ligament Cells

Twist negatively regulates osteoblastic differentiation in human periodontal ligament cells

2007 ◽  
Vol 100 (2) ◽  
pp. 303-314 ◽  
Author(s):  
Motohiro Komaki ◽  
Takeo Karakida ◽  
Mayumi Abe ◽  
Shinichiro Oida ◽  
Kaori Mimori ◽  
...  
Keyword(s):  
Periodontal Ligament ◽  
Osteoblastic Differentiation ◽  
Periodontal Ligament Cells ◽  
Human Periodontal Ligament Cells

scholarly journals Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Huxiao Li ◽  
Jianrong Xu ◽  
Xiaotian Li ◽  
Yi Hu ◽  
Yue Liao ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Periodontal Ligament ◽  
Target Genes ◽  
Chinese Herb ◽  
Periodontal Ligament Cells ◽  
Human Periodontal Ligament Cells ◽  
Estrogen Receptor Signaling ◽  
Receptor Signaling Pathway ◽  
Anti Inflammatory ◽  
Molecule Docking

AbstractPsoralen is one of the most effective ingredients extracted from the Chinese herb, Psoralea corylifolia L. Studies have found that psoralen has anti-inflammatory and estrogen-like effects; however, little research has been conducted to elucidate the mechanisms underlying these effects. Through the molecule docking assay, psoralen was found to have a better combination with ERα than ERβ. In human periodontal ligament cells, psoralen was found to upregulate the estrogen target genes (e.g., CTSD, PGR, TFF1) and down-regulate the expression of inflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-8) stimulated by P. gingivalis LPS, as well as TLR4-IRAK4-NF-κb signaling pathway proteins. These effects were reversed by the ER antagonist ICI 182780. These results indicated that psoralen may exert anti-inflammatory effects as an agonist to ER, which could provide a theoretical basis for the use of psoralen for adjuvant therapy and prevention of periodontitis.

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