Difference in release kinetics of unwashed and washed platelet-released supernatants from bone substitute materials: the impact of platelet preparation modalities

2017 ◽  
Vol 52 (4) ◽  
pp. 772-786 ◽  
Author(s):  
C. Knoop ◽  
M. Edelmayer ◽  
K. Janjić ◽  
M. Pensch ◽  
M. B. Fischer ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Release Kinetics ◽  
Washed Platelet ◽  
Bone Substitute Materials ◽  
The Impact ◽  
Kinetics Of ◽  
Substitute Materials

scholarly journals Antimicrobial Formulations of Absorbable Bone Substitute Materials as Drug Carriers Based on Calcium Sulfate

2016 ◽  
Vol 60 (7) ◽  
pp. 3897-3905 ◽  
Author(s):  
D. Pförringer ◽  
A. Obermeier ◽  
M. Kiokekli ◽  
H. Büchner ◽  
S. Vogt ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Ex Vivo ◽  
Release Kinetics ◽  
Drug Carriers ◽  
Prolonged Release ◽  
Clinical Parameters ◽  
Bone Substitute Materials ◽  
Substitute Materials

ABSTRACTSubstitution of bones is a well-established, necessary procedure to treat bone defects in trauma and orthopedic surgeries. For prevention or treatment of perioperative infection, the implantation of resorbable bone substitute materials carrying antibiotics is a necessary treatment. In this study, we investigated the newly formulated calcium-based resorbable bone substitute materials containing either gentamicin (CaSO4-G [Herafill-G]), vancomycin (CaSO4-V), or tobramycin (Osteoset). We characterized the released antibiotic concentration per unit. Bone substitute materials were implanted in bones of rabbits via a standardized surgical procedure. Clinical parameters and levels of the antibiotic-releasing materials in serum were determined. Local concentrations of antibiotics were measured using antimicrobial tests of bone tissue. Aminoglycoside release kineticsin vitroper square millimeter of bead surface showed the most prolonged release for gentamicin, followed by vancomycin and, with the fastest release, tobramycin.In vivolevel in serum detected over 28 days was highest for gentamicin at 0.42 μg/ml, followed by vancomycin at 0.11 μg/ml and tobramycin at 0.04 μg/ml. The clinical parameters indicated high biocompatibility for materials used. None of the rabbits subjected to the procedure showed any adverse reaction. The highest availability of antibiotics at 14.8 μg/g on day 1 in the cortical tibiaex vivowas demonstrated for gentamicin, decreasing within 14 days. In the medulla, vancomycin showed a high level at 444 μg/g on day 1, decreasing continuously over 14 days, whereas gentamicin decreased faster within the initial 3 days. The compared antibiotic formulations varied significantly in release kinetics in serum as well as locally in medulla and cortex.

Bone Substitute Materials in Modern Dentistry

2017 ◽  
Vol 1 (4) ◽  
Author(s):  
Andrius Geguzis ◽  
Inesa Astramskaite ◽  
Dovile Gabseviciute
Keyword(s):  
Bone Substitute ◽  
Bone Substitute Materials ◽  
Substitute Materials

In vitro effects of particulate bone substitute materials on the resorption activity of human osteoclasts

2017 ◽  
Vol 34 ◽  
pp. 291-306 ◽  
Author(s):  
G Russmueller ◽  
◽  
L Winkler ◽  
R Lieber ◽  
R Seemann ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Bone Substitute Materials ◽  
In Vitro Effects ◽  
Substitute Materials ◽  
Human Osteoclasts
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