Evaluation of a novel point-of-care test for active matrix metalloproteinase-8: agreement between qualitative and quantitative measurements and relation to periodontal inflammation

2016 ◽  
Vol 52 (2) ◽  
pp. 277-284 ◽  
Author(s):  
K. Lorenz ◽  
T. Keller ◽  
B. Noack ◽  
A. Freitag ◽  
L. Netuschil ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Point Of Care ◽  
Active Matrix ◽  
Qualitative And Quantitative ◽  
Point Of Care Test ◽  
Quantitative Measurements ◽  
Periodontal Inflammation

scholarly journals Active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) in the COVID-19 pandemic

2021 ◽  
Author(s):  
Timo Sorsa ◽  
Vaibhav Sahni ◽  
Nurcan Buduneli ◽  
Shipra Gupta ◽  
Ismo T. Räisänen ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Point Of Care ◽  
Active Matrix ◽  
Point Of Care Test

scholarly journals A point‐of‐care test of active matrix metalloproteinase‐8 predicts triggering receptor expressed on myeloid cells‐1 (TREM‐1) levels in saliva

2019 ◽  
Vol 91 (1) ◽  
pp. 102-109 ◽  
Author(s):  
Ismo T. Räisänen ◽  
Anna Maria Heikkinen ◽  
Elmira Pakbaznejad Esmaeili ◽  
Taina Tervahartiala ◽  
Riitta Pajukanta ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Point Of Care ◽  
Myeloid Cells ◽  
Active Matrix ◽  
Point Of Care Test

Diagnostic ability of salivary matrix metalloproteinase‐9 lateral flow test point‐of‐care test for periodontitis

2020 ◽  
Vol 47 (11) ◽  
pp. 1354-1361
Author(s):  
Hyun‐Duck Kim ◽  
Chang‐Soo Lee ◽  
Hyun‐Jae Cho ◽  
Sumin Jeon ◽  
Young‐Nim Choi ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Point Of Care ◽  
Test Point ◽  
Matrix Metalloproteinase 9 ◽  
Lateral Flow ◽  
Diagnostic Ability ◽  
Point Of Care Test ◽  
Flow Test ◽  
Lateral Flow Test ◽  
Metalloproteinase 9

scholarly journals Host-Modulation Therapy and Chair-Side Diagnostics in the Treatment of Peri-Implantitis

Biosensors ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 44 ◽  
Author(s):  
Timo Sorsa ◽  
Joseph Bacigalupo ◽  
Mauno Könönen ◽  
Pirjo Pärnänen ◽  
Ismo T. Räisänen
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Diagnostic Tools ◽  
Low Grade ◽  
Active Matrix ◽  
Point Of Care Test ◽  
Increased Risk ◽  
Prevention And Treatment ◽  
Potential Benefits ◽  
Low Grade Inflammation

Previous studies report periodontitis and peri-implantitis being able to induce systemic low-grade inflammation, which is known to be associated with increased risk for some systemic medical disease such as cardiovascular disease. In this regard, recent studies have shown that host modulation therapy (HMT) together with traditional mechanical and surgical treatment not only cease the progression of periodontitis but also reduce the systemic collagenolytic biomarkers in both oral fluids and circulation. This suggests that the corresponding adjunctive HMT-medication could be effective in the prevention and treatment of dental peri-implantitis, as well. Furthermore, low-cost, safe, and practical oral fluid active matrix metalloproteinase-8 (aMMP-8) lateral-flow immunotests have been proposed as point-of-care/chair-side diagnostic tools to detect peri-implantitis and periodontitis, and to monitor their effective resolutions, while using various therapeutic strategies, including host modulation. This study reports the potential benefits of HMT-medication in the prevention and treatment of dental peri-implantitis among five patients (four of five were current/ex-smokers). In addition, the aMMP-8 point-of-care test diagnosed 20 peri-implantitis and 20 healthy controls correctly. In conclusion, this study and previous studies support the potential effectiveness of HMT-medication(s) and point-of-care/chair-side technologies in the treatment and diagnostics/monitoring of peri-implantitis. However, more studies are needed to further confirm this.

Changes in the Matrix Metalloproteinase 9 Point-of-Care Test Positivity According to MMP-9 Concentration and Loading Volume

Cornea ◽  
2020 ◽  
Vol 39 (2) ◽  
pp. 234-236
Author(s):  
Jungah Huh ◽  
Soo Youn Choi ◽  
Youngsub Eom ◽  
Hyo Myung Kim ◽  
Jong Suk Song
Keyword(s):  
Matrix Metalloproteinase ◽  
Point Of Care ◽  
Matrix Metalloproteinase 9 ◽  
Point Of Care Test ◽  
The Matrix ◽  
Metalloproteinase 9

scholarly journals Dry Eye Profiles in Patients with a Positive Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test Versus Negative Patients

2016 ◽  
Vol 14 (2) ◽  
pp. 216-223 ◽  
Author(s):  
Nicole L. Lanza ◽  
Allison L. McClellan ◽  
Hatim Batawi ◽  
Elizabeth R. Felix ◽  
Konstantinos D. Sarantopoulos ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Dry Eye ◽  
Point Of Care ◽  
Matrix Metalloproteinase 9 ◽  
Point Of Care Test ◽  
Elevated Surface ◽  
Metalloproteinase 9

Evaluation of point-of-care test for elevated tear matrix metalloproteinase 9 in post-LASIK dry eyes

2015 ◽  
Vol 100 (9) ◽  
pp. 1188-1191 ◽  
Author(s):  
Tommy C Y Chan ◽  
Cong Ye ◽  
Kwok Ping Chan ◽  
Kai On Chu ◽  
Vishal Jhanji
Keyword(s):  
Matrix Metalloproteinase ◽  
Point Of Care ◽  
Matrix Metalloproteinase 9 ◽  
Dry Eyes ◽  
Point Of Care Test ◽  
Metalloproteinase 9

scholarly journals aMMP-8 Point-of-Care/Chairside Oral Fluid Technology as a Rapid, Non-Invasive Tool for Periodontitis and Peri-Implantitis Screening in a Medical Care Setting

Diagnostics ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 562 ◽  
Author(s):  
Hanna Lähteenmäki ◽  
Kehinde A. Umeizudike ◽  
Anna Maria Heikkinen ◽  
Ismo T. Räisänen ◽  
Nilminie Rathnayake ◽  
...  
Keyword(s):  
Medical Care ◽  
Oral Fluid ◽  
Care Setting ◽  
Point Of Care ◽  
Active Matrix ◽  
Non Invasive ◽  
Point Of Care Test ◽  
Essential Value ◽  
Periodontal Breakdown ◽  
Periodontal Diagnostics

This communication article addresses currently available rapid non-invasive methods to screen and detect periodontitis and dental peri-implantitis. In this regard, oral fluid biomarkers have been researched extensively but self-reported oral health (SROH)-questionnaires have also been developed. Both alternatives may offer a quick and easy way to screen and detect diseased patients. Active matrix metalloproteinase (aMMP-8) is one of the most validated biomarkers for screening and detecting periodontal breakdown related to periodontitis and peri-implantitis and monitoring their treatment effects revealing successful, less- and non-successful treatment results. Currently available aMMP-8 lateral-flow technologies allow this kind of analysis, as demonstrated here, to be conducted quantitatively online and real-time as point-of-care/chairside testing in dental and even medical care settings. In this study, an aMMP-8 peri-implant sulcular fluid point-of-care-test diagnosed peri-implantitis and healthy implants far more accurately than bleeding-on-probing or the other biomarkers, such as polymorphonuclear (PMN)/neutrophil elastase, myeloperoxidase and MMP-9. Although, SROH-questionnaires allow screening in similar settings but they lack the information about the current disease activity of periodontitis and peri-implantitis, which is of essential value in periodontal diagnostics and treatment monitoring. Thus, both methods can be considered as adjunct methods for periodontitis and peri-implant diagnostics, but the value of oral fluid biomarkers analysis does not seem to be substitutable.

Keratoconus Progression in Patients With Allergy and Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test

2018 ◽  
Vol 44 ◽  
pp. S48-S53 ◽  
Author(s):  
Cosimo Mazzotta ◽  
Claudio Traversi ◽  
Pierfrancesco Mellace ◽  
Simone A. Bagaglia ◽  
Silvio Zuccarini ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Point Of Care ◽  
Matrix Metalloproteinase 9 ◽  
Point Of Care Test ◽  
Elevated Surface ◽  
Metalloproteinase 9

scholarly journals The Matrix Metalloproteinase 9 Point-of-Care Test in Dry Eye

2016 ◽  
Vol 14 (2) ◽  
pp. 189-195 ◽  
Author(s):  
Nicole L. Lanza ◽  
Felipe Valenzuela ◽  
Victor L. Perez ◽  
Anat Galor
Keyword(s):  
Matrix Metalloproteinase ◽  
Dry Eye ◽  
Point Of Care ◽  
Matrix Metalloproteinase 9 ◽  
Point Of Care Test ◽  
The Matrix ◽  
Metalloproteinase 9
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