Redefining the induction of periodontal tissue regeneration in primates by the osteogenic proteins of the transforming growth factor-β supergene family

2016 ◽  
Vol 51 (6) ◽  
pp. 699-715 ◽  
Author(s):  
U. Ripamonti
Keyword(s):  
Growth Factor ◽  
Tissue Regeneration ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Periodontal Tissue ◽  
Periodontal Tissue Regeneration ◽  
Supergene Family

scholarly journals Hubungan kualitas darah dengan konsentrasi transforming growth factor-β pada platelet rich plasma yang digunakan untuk regenerasi tulang dan jaringan periodontal (Correlation of blood quality with concentration of transforming growth factor-ß1 in platelet rich plasma for bone and periodontal tissue regeneration)

2014 ◽  
Vol 13 (2) ◽  
pp. 80
Author(s):  
Surijana Mappangara ◽  
Burhanuddin DP ◽  
Arni Irawaty Djais
Keyword(s):  
Growth Factor ◽  
Tissue Regeneration ◽  
Transforming Growth Factor ◽  
Platelet Rich Plasma ◽  
P Value ◽  
Periodontal Tissue ◽  
Spearman Correlation ◽  
Correlation Test ◽  
Periodontal Tissue Regeneration ◽  
Spearman Correlation Test

This study aimed to explore the correlation of blood quality with transforming growth factor (TGF-ß1) of platelet richplasma (PRP) which was used for bone and periodontal tissue regeneration. Thirty nine subjects participated in thisstudy. Data of age, gender, eritrocyt, leucocyt, hemoglobin, thrombocyt, and TGF-ß1 concentration were used toanalyze the correlation using Spearman correlation test. This study found leucocyt, eritrocyt, hemoglobin, thrombocytconcentration mean was 8.19 g/dl, 5.31 g/dl, 14.48 g/dl, 326.32 g/dl, respectively. The TGF-ß1 concentration meanacquired from PRP was 31994.27 pg/ml. Based on Spearman correlation test, significant correlation was onlyobserved in eritrocyt concentration variable with p value 0.023 (p<0.05) and it was higher in male than in female. It was concluded that TGF-ß1 concentration in PRP from normal subject was 31994.27 pg/ml. Based on leucocyt,eritrocyt, hemoglobin, and thrombocyt test to TGF-ß1, only eritrocyt showed the significant relationship. This findingalso showed the linear correlation between the amoung of eritrocyt in blood with TGF-ß1 as the increased eritrocytvalue was followed by the excalated TGF-ß1 value.

The induction of bone formation: From bone morphogenetic proteins to the transforming growth factor-β3 protein - Redundancy, pleiotropy and the induction of cementogenesis

2021 ◽  
Vol 76 (06) ◽  
pp. 331-356
Author(s):  
Ugo Ripamont
Keyword(s):  
Growth Factor ◽  
Bone Formation ◽  
Bone Morphogenetic Proteins ◽  
Transforming Growth Factor ◽  
Alveolar Bone ◽  
Transforming Growth Factor Β ◽  
Periodontal Tissue ◽  
Rapid Induction ◽  
Furcation Defects ◽  
Expression Pathways

This review proposes to translate organogenesis and the induction of bone formation by the recombinant human transforming growth factor-β3 (hTGF-β3 ) in the Chacma baboon Papio ursinus to periodontal tissue induction and regeneration. Naturally derived highly purified osteogenic proteins of the transforming growth factor-β (TGF-β) supergene family were implanted in Class II furcation defects of the first and second mandibular molars. Additional defects in P.ursinus were treated with recombinant human osteogenic protein-1 (hOP-1, also known as bone morphogeneticprotein-7, hBMP-7) and hBMP-2, singly or in binary applications. In different studies defects were also implanted with hTGF-β3singly or in binary application with hOP-1. Harvested specimens on day 60 and 180 were processed for undecalcified histology using tungsten-carbide knives mounted on Polycut sledge’ micro-tomes or the Exakt precision cutting and grinding system.Highly purified osteogenic proteins showed the induction of Sharpey’s fibres into newly formed cementoid with foci of mineralization. hOP-1 induced substantial cementogenesis whilst hBMP-2 preferentially induced alveolar bone. Intramuscular implantation of hTGF-β3 absorbed onto coral-derived macroporous bioreactors engineered large heterotopic multicellular bone organoids. Gene expression pathways by quantitative Reverse Transcription Polymerases Chain Reaction (qRT-PCR) show that the induction of bone is via several profiled BMPs and TGF-βs expressed upon implantation of hTGF-β3 recapitulating the synergistic induction of bone as shown by binary applications of low doses of hTGF-β1 and hTGF-β3with hOP-1. The rapid induction of bone by hTGF-β3 provides theframework for a paradigmatic shift from recombinanthBMPs to hTGF-β3 in clinical contexts, provocatively operational in periodontal tissue regeneration with substantial induction of cementogenesis in angiogenesis.

scholarly journals Periodontal Tissue Regeneration Using Fibroblast Growth Factor -2: Randomized Controlled Phase II Clinical Trial

PLoS ONE ◽  
2008 ◽  
Vol 3 (7) ◽  
pp. e2611 ◽  
Author(s):  
Masahiro Kitamura ◽  
Keisuke Nakashima ◽  
Yusuke Kowashi ◽  
Takeo Fujii ◽  
Hidetoshi Shimauchi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Phase Ii ◽  
Tissue Regeneration ◽  
Fibroblast Growth Factor 2 ◽  
Periodontal Tissue ◽  
Fibroblast Growth ◽  
Randomized Controlled ◽  
Periodontal Tissue Regeneration
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