Effects of daidzein on alveolar bone loss and internal microstructures of bone in a rat model of experimental periodontitis: a study using micro-computed tomography

2015 ◽  
Vol 51 (2) ◽  
pp. 250-256 ◽  
Author(s):  
S. H. Bae ◽  
M. H. Ha ◽  
E.-Y. Choi ◽  
J.-I. Choi ◽  
I. S. Choi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Loss ◽  
Rat Model ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Micro Computed Tomography ◽  
Experimental Periodontitis

scholarly journals Stemodia maritima L. Extract Decreases Inflammation, Oxidative Stress, and Alveolar Bone Loss in an Experimental Periodontitis Rat Model

2017 ◽  
Vol 8 ◽  
Author(s):  
Alrieta H. Teixeira ◽  
Jordânia M. de Oliveira Freire ◽  
Luzia H. T. de Sousa ◽  
Antônia T. Parente ◽  
Nayara A. de Sousa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bone Loss ◽  
Rat Model ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Experimental Periodontitis

Three-Dimensional Quantification of Alveolar Bone Loss inPorphyromonas gingivalis-Infected Mice Using Micro-Computed Tomography

2005 ◽  
Vol 76 (8) ◽  
pp. 1282-1286 ◽  
Author(s):  
Asaf Wilensky ◽  
Yankel Gabet ◽  
Hiromichi Yumoto ◽  
Yael Houri-Haddad ◽  
Lior Shapira
Keyword(s):  
Computed Tomography ◽  
Bone Loss ◽  
Alveolar Bone ◽  
Three Dimensional ◽  
Alveolar Bone Loss ◽  
Micro Computed Tomography

3,4,5-Trihydroxybenzoic acid attenuates ligature-induced periodontal disease in Wistar rats.

2020 ◽  
Vol 19 ◽  
Author(s):  
Ozkan Karatas ◽  
Fikret Gevrek
Keyword(s):  
Bone Loss ◽  
Gallic Acid ◽  
Wistar Rats ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Collagenase Activity ◽  
Osteoblastic Activity ◽  
Cell Counts ◽  
Experimental Periodontitis ◽  
Anti Inflammatory

Background: 3,4,5-Trihydroxybenzoic acid, which is also known as gallic acid, is an anti-inflammatory agent who could provide beneficial effects in preventing periodontal inflammation. The present study aimed to evaluate the anti-inflammatory effects of gallic acid on experimental periodontitis in Wistar rats. Alveolar bone loss, osteoclastic activity, osteoblastic activity, and collagenase activity were also determined. Methods: 32 Wistar rats were used in the present study. Study groups were created as following: Healthy control (C,n=8) group; periodontitis (P,n=8) group; periodontitis and 30 mg/kg gallic acid administered group (G30,n=8); periodontitis and 60 mg/kg gallic acid administered group (G60,n=8). Experimental periodontitis was created by placing 4-0 silk sutures around the mandibular right first molar tooth. Morphological changes in alveolar bone were determined by stereomicroscopic evaluation. Mandibles were undergone histological evaluation. Matrix metalloproteinase (MMP)-8, tissue inhibitor of MMPs (TIMP)-1, bone morphogenetic protein (BMP)-2 expressions, tartrate-resistant acid phosphatase (TRAP) positive osteoclast cells, osteoblast, and inflammatory cell counts were determined. Results: Highest alveolar bone loss was observed in the periodontitis group. Both doses of gallic acid decreased alveolar bone loss compared to the P group. TRAP-positive osteoclast cell counts were higher in the P group, and gallic acid successfully lowered these counts. Osteoblast cells also increased in gallic acid administered groups. Inflammation in the P group was also higher than those of C, G30, and G60 groups supporting the role of gallic acid in preventing inflammation. 30 and 60 mg/kg doses of gallic acid decreased MMP-8 levels and increased TIMP-1 levels. BMP levels increased in gallic acid administered groups, similar to several osteoblasts. Conclusion: Present results revealed an anti-inflammatory effect of gallic acid, which was indicated by decreased alveolar bone loss and collagenase activity and increased osteoblastic activity.

scholarly journals SOCS-3 Regulates Alveolar Bone Loss in Experimental Periodontitis

2016 ◽  
Vol 95 (9) ◽  
pp. 1018-1025 ◽  
Author(s):  
E. Papathanasiou ◽  
A. Kantarci ◽  
A. Konstantinidis ◽  
H. Gao ◽  
T.E. Van Dyke
Keyword(s):  
Bone Loss ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Experimental Periodontitis

Humic Acid, a Polyphenolic Substance, Decreases Alveolar Bone Loss in Experimental Periodontitis in Rats

2019 ◽  
Vol 36 (4) ◽  
pp. 257-265
Author(s):  
Metin Çalışır ◽  
Aysun Akpınar ◽  
Ömer Poyraz ◽  
Fahrettin Göze ◽  
Ziynet Çınar
Keyword(s):  
Humic Acid ◽  
Bone Loss ◽  
Inflammatory Cell ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Inflammatory Cell Infiltration ◽  
Cell Infiltration ◽  
Enzyme Linked Immunosorbent Assay ◽  
Local Administration ◽  
Experimental Periodontitis

The purpose of this study was to evaluate the biochemical, morphometric, and histopathological changes associated with experimental periodontitis in rats in response to local administration of humic acid. Thirty-eight Wistar rats were divided into 5 experimental groups: nonligated (NL) group, ligature-only (LO) group, and ligature + local administration of humic acid (20, 80, and 150 mg/kg body weight per day for 15 days, respectively; L-20, L-80, and L-150 groups). Changes in alveolar bone levels were clinically measured as the distance from the cementoenamel junction to the alveolar bone crest with a stereomicroscope. Tissues were histopathologically examined to assess the osteoclast numbers, osteoblastic activity, and inflammatory cell infiltration among the study groups. Enzyme-linked immunosorbent assay interleukin1β (IL-1β) and IL-10 levels in serum and gingival homogenates were evaluated. At the end of 15 days, the alveolar bone loss was significantly higher in the LO group compared to the NL, L-20, and L-150 groups ( P < .05). The osteoclast number in the LO group was significantly higher than the NL, L-20, and L-150 groups ( P < .05). Inflammatory cell infiltration was significantly higher in the LO and L-80 groups than the other groups ( P < .05). The highest serum and gingival homogenate IL-10 levels were determined in the NL group ( P < .05). The serum and gingival homogenate IL-1β levels in LO group were significantly higher than the NL, L-20, and L-150 groups ( P < .05). Within the limits of this study, it can be suggested that humic acid, when administered locally at 20 and 80 mg/kg doses, may prevent alveolar bone loss in the rat model.

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