Monitoring bone morphogenetic protein-2 and -7, soluble receptor activator of nuclear factor-κB ligand and osteoprotegerin levels in the peri-implant sulcular fluid during the osseointegration of hydrophilic-modified sandblasted acid-etched and sandblaste

2014 ◽  
Vol 50 (1) ◽  
pp. 62-73 ◽  
Author(s):  
D. Dolanmaz ◽  
M. Saglam ◽  
O. Inan ◽  
N. Dundar ◽  
G. Alniacık ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Nuclear Factor Κb ◽  
Bone Morphogenetic Protein 2 ◽  
Nuclear Factor ◽  
Soluble Receptor ◽  
Morphogenetic Protein ◽  
Receptor Activator

scholarly journals Osteoblasts Provide a Suitable Microenvironment for the Action of Receptor Activator of Nuclear Factor-κB Ligand

Endocrinology ◽  
2006 ◽  
Vol 147 (7) ◽  
pp. 3366-3374 ◽  
Author(s):  
Yohei Yamamoto ◽  
Nobuyuki Udagawa ◽  
Sachiko Matsuura ◽  
Yuko Nakamichi ◽  
Hiroshi Horiuchi ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Nuclear Factor Κb ◽  
Bone Morphogenetic Protein 2 ◽  
Nuclear Factor ◽  
Serum Concentrations ◽  
Morphogenetic Protein ◽  
Ectopic Bone ◽  
Rankl Mrna ◽  
Receptor Activator ◽  
And Control

Deficiency of osteoprotegerin (OPG), a soluble decoy receptor for receptor activator of nuclear factor-κB ligand (RANKL), in mice induces osteoporosis caused by enhanced bone resorption. Serum concentrations of RANKL are extremely high in OPG-deficient (OPG−/−) mice, suggesting that circulating RANKL is involved in osteoclastogenesis. RANKL−/− mice exhibit osteopetrosis, with the absence of osteoclasts. We examined the requirements for osteoclastogenesis using OPG−/− mice, RANKL−/− mice, and a system involving bone morphogenetic protein 2 (BMP-2)-induced ectopic bone formation. When collagen disks containing BMP-2 (BMP-2-disks) or vehicle were implanted into OPG−/− mice, osteoclast-like cells (OCLs) and alkaline phosphatase-positive OCLs appeared in BMP-2-disks but not the control disks. F4/80-positive osteoclast precursors were similarly distributed in both BMP-2- and control disks. Cells expressing RANKL were detected in the BMP-2-disks, and the addition of OPG to the disk inhibited OCL formation. Muscle cells in culture differentiated into alkaline phosphatase-positive cells in the presence of BMP-2 and accordingly expressed RANKL mRNA in response to PTH. This suggests that RANKL expressed by osteoblasts is a requirement for osteoclastogenesis. We then examined how osteoblasts are involved in osteoclastogenesis other than RANKL expression, using RANKL−/− mice. BMP-2- and control disks were implanted into RANKL−/− mice, which were injected with RANKL for 7 d. Many OCLs were observed in the BMP-2-disks and bone tissues but not the control disks. These results suggest that osteoblasts also play important roles in osteoclastogenesis through offering the critical microenvironment for the action of RANKL.

scholarly journals Therapeutic efficacy of soluble receptor activator of nuclear factor-κB-Fc delivered by nonviral gene transfer in a mouse model of osteolytic osteosarcoma

2008 ◽  
Vol 7 (10) ◽  
pp. 3389-3398 ◽  
Author(s):  
François Lamoureux ◽  
Gaëlle Picarda ◽  
Julie Rousseau ◽  
Clothilde Gourden ◽  
Séverine Battaglia ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Mouse Model ◽  
Therapeutic Efficacy ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Soluble Receptor ◽  
Nonviral Gene Transfer ◽  
Receptor Activator

scholarly journals Cathepsin G Enhances Mammary Tumor–Induced Osteolysis by Generating Soluble Receptor Activator of Nuclear Factor-κB Ligand

2008 ◽  
Vol 68 (14) ◽  
pp. 5803-5811 ◽  
Author(s):  
Thomas J. Wilson ◽  
Kalyan C. Nannuru ◽  
Mitsuru Futakuchi ◽  
Anguraj Sadanandam ◽  
Rakesh K. Singh
Keyword(s):  
Mammary Tumor ◽  
Nuclear Factor Κb ◽  
Cathepsin G ◽  
Nuclear Factor ◽  
Soluble Receptor ◽  
Receptor Activator

Soluble Receptor Activator of Nuclear Factor-κB Ligand (sRANKL)/Osteoprotegerin Balance in Ageing and Age-Associated Diseases

2004 ◽  
Vol 5 (2) ◽  
pp. 119-127 ◽  
Author(s):  
Lia Pulsatelli ◽  
Paolo Dolzani ◽  
Tania Silvestri ◽  
Paolo Caraceni ◽  
Andrea Facchini ◽  
...  
Keyword(s):  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Soluble Receptor ◽  
Associated Diseases ◽  
Receptor Activator
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