Osteogenic differentiation of human periodontal ligament cells after transfection with recombinant lentiviral vector containing follicular dendritic cell secreted protein

2013 ◽  
Vol 49 (5) ◽  
pp. 554-562 ◽  
Author(s):  
L. Xiang ◽  
L. Ma ◽  
Y. He ◽  
N. Wei ◽  
P. Gong
Keyword(s):  
Dendritic Cell ◽  
Osteogenic Differentiation ◽  
Periodontal Ligament ◽  
Lentiviral Vector ◽  
Follicular Dendritic Cell ◽  
Periodontal Ligament Cells ◽  
Secreted Protein ◽  
Human Periodontal Ligament Cells ◽  
Follicular Dendritic

scholarly journals Gold Nanoparticles Combined Human β-Defensin 3 Gene-Modified Human Periodontal Ligament Cells Alleviate Periodontal Destruction via the p38 MAPK Pathway

2021 ◽  
Vol 9 ◽  
Author(s):  
Lingjun Li ◽  
Yangheng Zhang ◽  
Min Wang ◽  
Jing Zhou ◽  
Qian Zhang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Osteogenic Differentiation ◽  
P38 Mapk ◽  
Periodontal Ligament ◽  
Mapk Pathway ◽  
Periodontal Regeneration ◽  
Periodontal Ligament Cells ◽  
Human Periodontal Ligament Cells ◽  
P38 Mapk Pathway

Periodontitis is a chronic inflammatory disease with plaques as the initiating factor, which will induce the destruction of periodontal tissues. Numerous studies focused on how to obtain periodontal tissue regeneration in inflammatory environments. Previous studies have reported adenovirus-mediated human β-defensin 3 (hBD3) gene transfer could potentially enhance the osteogenic differentiation of human periodontal ligament cells (hPDLCs) and bone repair in periodontitis. Gold nanoparticles (AuNPs), the ideal inorganic nanomaterials in biomedicine applications, were proved to have synergetic effects with gene transfection. To further observe the potential promoting effects, AuNPs were added to the transfected cells. The results showed the positive effects of osteogenic differentiation while applying AuNPs into hPDLCs transfected by adenovirus encoding hBD3 gene. In vivo, after rat periodontal ligament cell (rPDLC) transplantation into SD rats with periodontitis, AuNPs combined hBD3 gene modification could also promote periodontal regeneration. The p38 mitogen-activated protein kinase (MAPK) pathway was demonstrated to potentially regulate both the in vitro and in vivo processes. In conclusion, AuNPs can promote the osteogenic differentiation of hBD3 gene-modified hPDLCs and periodontal regeneration via the p38 MAPK pathway.

scholarly journals Morinda citrifolia leaves enhance osteogenic differentiation and mineralization of human periodontal ligament cells

2012 ◽  
Vol 31 (5) ◽  
pp. 863-871 ◽  
Author(s):  
Kanitsak BOONANANTANASARN ◽  
Kajohnkiart JANEBODIN ◽  
Prapan SUPPAKPATANA ◽  
Tawepong ARAYAPISIT ◽  
Jit-aree RODSUTTHI ◽  
...  
Keyword(s):  
Osteogenic Differentiation ◽  
Periodontal Ligament ◽  
Morinda Citrifolia ◽  
Periodontal Ligament Cells ◽  
Human Periodontal Ligament Cells
Sign in / Sign up

Export Citation Format

Share Document