Antimicrobial effect of photodynamic therapy using high-power blue light-emitting diode and red-dye agent on Porphyromonas gingivalis

2013 ◽  
Vol 48 (6) ◽  
pp. 696-705 ◽  
Author(s):  
C. Chui ◽  
A. Aoki ◽  
Y. Takeuchi ◽  
Y. Sasaki ◽  
K. Hiratsuka ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Blue Light ◽  
Porphyromonas Gingivalis ◽  
High Power ◽  
Light Emitting Diode ◽  
Antimicrobial Effect ◽  
Light Emitting ◽  
Red Dye

scholarly journals In Vitro Effect of Photodynamic Therapy with Different Lights and Combined or Uncombined with Chlorhexidine on Candida spp.

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1176
Author(s):  
Vanesa Pérez-Laguna ◽  
Yolanda Barrena-López ◽  
Yolanda Gilaberte ◽  
Antonio Rezusta
Keyword(s):  
Photodynamic Therapy ◽  
Light Emitting Diode ◽  
Antimicrobial Effect ◽  
Photodynamic Treatment ◽  
Candida Spp ◽  
Promising Alternative ◽  
Light Emitting ◽  
Colony Forming Units ◽  
Vitro Effect

Candidiasis is very common and complicated to treat in some cases due to increased resistance to antifungals. Antimicrobial photodynamic therapy (aPDT) is a promising alternative treatment. It is based on the principle that light of a specific wavelength activates a photosensitizer molecule resulting in the generation of reactive oxygen species that are able to kill pathogens. The aim here is the in vitro photoinactivation of three strains of Candida spp., Candida albicans ATCC 10231, Candida parapsilosis ATCC 22019 and Candida krusei ATCC 6258, using aPDT with different sources of irradiation and the photosensitizer methylene blue (MB), alone or in combination with chlorhexidine (CHX). Irradiation was carried out at a fluence of 18 J/cm2 with a light-emitting diode (LED) lamp emitting in red (625 nm) or a white metal halide lamp (WMH) that emits at broad-spectrum white light (420–700 nm). After the photodynamic treatment, the antimicrobial effect is evaluated by counting colony forming units (CFU). MB-aPDT produces a 6 log10 reduction in the number of CFU/100 μL of Candida spp., and the combination with CHX enhances the effect of photoinactivation (effect achieved with lower concentration of MB). Both lamps have similar efficiencies, but the WMH lamp is slightly more efficient. This work opens the doors to a possible clinical application of the combination for resistant or persistent forms of Candida infections.

High power and high efficiency blue light emitting diode on freestanding semipolar (101¯1¯) bulk GaN substrate

2007 ◽  
Vol 90 (23) ◽  
pp. 233504 ◽  
Author(s):  
Hong Zhong ◽  
Anurag Tyagi ◽  
Natalie N. Fellows ◽  
Feng Wu ◽  
Roy B. Chung ◽  
...  
Keyword(s):  
Blue Light ◽  
High Power ◽  
High Efficiency ◽  
Light Emitting Diode ◽  
Light Emitting ◽  
Bulk Gan

scholarly journals High-power light-emitting diode array design and assembly for practical photodynamic therapy research

2020 ◽  
Vol 25 (06) ◽  
pp. 1 ◽  
Author(s):  
Eric M. Kercher ◽  
Kai Zhang ◽  
Matt Waguespack ◽  
Ryan T. Lang ◽  
Alejandro Olmos ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
High Power ◽  
Light Emitting Diode ◽  
Diode Array ◽  
Array Design ◽  
Light Emitting

scholarly journals Application of Teeth Whitening LED for Prevention of Dental Caries : Antimicrobial Photodynamic Therapy Approach

2020 ◽  
Vol 47 (1) ◽  
pp. 70-77
Author(s):  
Choa Park ◽  
Howon Park ◽  
Juhyun Lee ◽  
Hyunwoo Seo ◽  
Siyoung Lee
Keyword(s):  
Photodynamic Therapy ◽  
Laser Scanning ◽  
Light Emitting Diode ◽  
Antimicrobial Effect ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Control Group ◽  
Antimicrobial Photodynamic Therapy ◽  
Group Dynamic ◽  
Light Emitting

The present study is aimed to assess the effect of antimicrobial photodynamic therapy (aPDT) on <i>Streptococcus mutans</i> biofilm through teeth whitening light emitting diode (LED).<br/>Planktonic and dynamic biofilm state cultures of <i>S. mutans</i> were used. Erythrosine 20 μM/L was used as the photosensitizer. Irradiation was performed by exposing cultures to clinic and homecare whitening LEDs for 15 minutes. The viability was measured through Colony Forming Unit counts and confocal laser scanning microscopy.<br/>aPDT using whitening LEDs and erythrosine significantly decreased the CFU count of <i>S. mutans</i> compared to that in the control group. Dynamic biofilm group showed more resistant features to aPDT compared with planktonic state. Clinic and homecare whitening LED device showed similar antimicrobial effect.<br/>The whitening LED, which could irradiate the entire oral arch, showed a significant photodynamic effect on cariogenic <i>S. mutans</i> biofilm. aPDT mediated by erythrosine and LEDs used for teeth whitening exhibited promising antimicrobial activity.

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