Excessive Wnt/β-catenin signaling disturbs tooth-root formation

2012 ◽  
Vol 48 (4) ◽  
pp. 405-410 ◽  
Author(s):  
C. H. Bae ◽  
J. Y. Lee ◽  
T. H. Kim ◽  
J. A. Baek ◽  
J. C. Lee ◽  
...  
Keyword(s):  
Root Formation ◽  
Tooth Root

scholarly journals Localization of Runx2, Osterix, and Osteopontin in Tooth Root Formation in Rat Molars

2008 ◽  
Vol 57 (4) ◽  
pp. 397-403 ◽  
Author(s):  
Azumi Hirata ◽  
Toshio Sugahara ◽  
Hiroaki Nakamura
Keyword(s):  
Root Formation ◽  
Tooth Root ◽  
Rat Molars

Immortalized Hertwig's epithelial root sheath cell line works as model for epithelial–mesenchymal interaction during tooth root formation

2019 ◽  
Vol 235 (3) ◽  
pp. 2698-2709 ◽  
Author(s):  
Sicheng Zhang ◽  
Xuebing Li ◽  
Shikai Wang ◽  
Yan Yang ◽  
Weihua Guo ◽  
...  
Keyword(s):  
Cell Line ◽  
Root Formation ◽  
Tooth Root ◽  
Sheath Cell ◽  
Hertwig’S Epithelial Root Sheath ◽  
Root Sheath

scholarly journals Signaling Pathways Critical for Tooth Root Formation

2017 ◽  
Vol 96 (11) ◽  
pp. 1221-1228 ◽  
Author(s):  
J. Wang ◽  
J.Q. Feng
Keyword(s):  
Signaling Pathways ◽  
Root Formation ◽  
Root Resorption ◽  
Tooth Development ◽  
Critical Role ◽  
Future Research ◽  
Tooth Root ◽  
Short Root ◽  
Dentin Formation

Tooth is made of an enamel-covered crown and a cementum-covered root. Studies on crown dentin formation have been a major focus in tooth development for several decades. Interestingly, the population prevalence for genetic short root anomaly (SRA) with no apparent defects in crown is close to 1.3%. Furthermore, people with SRA itself are predisposed to root resorption during orthodontic treatment. The discovery of the unique role of Nfic (nuclear factor I C; a transcriptional factor) in controlling root but not crown dentin formation points to a new concept: tooth crown and root have different control mechanisms. Further genetic mechanism studies have identified more key molecules (including Osterix, β-catenin, and sonic hedgehog) that play a critical role in root formation. Extensive studies have also revealed the critical role of Hertwig’s epithelial root sheath in tooth root formation. In addition, Wnt10a has recently been found to be linked to multirooted tooth furcation formation. These exciting findings not only fill the critical gaps in our understanding about tooth root formation but will aid future research regarding the identifying factors controlling tooth root size and the generation of a whole “bio-tooth” for therapeutic purposes. This review starts with human SRA and mainly focuses on recent progress on the roles of NFIC-dependent and NFIC-independent signaling pathways in tooth root formation. Finally, this review includes a list of the various Cre transgenic mouse lines used to achieve tooth root formation–related gene deletion or overexpression, as well as strengths and limitations of each line.

New population of odontoblasts responsible for tooth root formation

2013 ◽  
Vol 13 (5-6) ◽  
pp. 197-202 ◽  
Author(s):  
Cheol-Hyeon Bae ◽  
Tak-Heun Kim ◽  
Jung-Yob Chu ◽  
Eui-Sic Cho
Keyword(s):  
Root Formation ◽  
Tooth Root

scholarly journals Osterix Regulates Tooth Root Formation in a Site-specific Manner

2015 ◽  
Vol 94 (3) ◽  
pp. 430-438 ◽  
Author(s):  
T.H. Kim ◽  
C.H. Bae ◽  
J.C. Lee ◽  
J.E. Kim ◽  
X. Yang ◽  
...  
Keyword(s):  
Root Formation ◽  
Tooth Root ◽  
Site Specific ◽  
Specific Manner ◽  
A Site

Bobby sox homolog regulates tooth root formation through modulation of dentin sialophosphoprotein

2020 ◽  
Vol 236 (1) ◽  
pp. 480-488
Author(s):  
Hye Jung Ihn ◽  
Ju Ang Kim ◽  
Jiwon Lim ◽  
Sang‐Hyeon Nam ◽  
So Hyeon Hwang ◽  
...  
Keyword(s):  
Root Formation ◽  
Tooth Root ◽  
Dentin Sialophosphoprotein
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