Oestrogen promotes lipids transportation through oestrogen receptor α in hepatic steatosis of geese in vitro

2021 ◽  
Author(s):  
Yan Deng ◽  
Junsong Yuan ◽  
Jiamin Qiu ◽  
Bincheng Tang ◽  
Xuefei Chen ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Oestrogen Receptor ◽  
Oestrogen Receptor Α

Screening of potential oestrogen receptor α agonists in pesticides via in silico, in vitro and in vivo methods

2021 ◽  
Vol 270 ◽  
pp. 116015
Author(s):  
Chao Shen ◽  
Kongyang Zhu ◽  
Jinpeng Ruan ◽  
Jialing Li ◽  
Yi Wang ◽  
...  
Keyword(s):  
In Silico ◽  
Oestrogen Receptor ◽  
Oestrogen Receptor Α

Norethisterone is bioconverted to oestrogenic compounds that activate both the oestrogen receptor α and oestrogen receptor β in vitro

2002 ◽  
Vol 452 (3) ◽  
pp. 347-355 ◽  
Author(s):  
Ana Maria Pasapera ◽  
Rubén Gutiérrez-Sagal ◽  
Joaquı́n Herrera ◽  
Norma Galicia-Canales ◽  
Gustavo Garcı́a de la Mora ◽  
...  
Keyword(s):  
Oestrogen Receptor ◽  
Oestrogen Receptor Α

scholarly journals E3 ubiquitin ligase Grail promotes hepatic steatosis through Sirt1 inhibition

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Pei-Yao Liu ◽  
Cheng-Cheung Chen ◽  
Chia-Ying Chin ◽  
Te-Jung Liu ◽  
Wen-Chiuan Tsai ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Lipid Accumulation ◽  
Acid Synthesis ◽  
Sirtuin 1 ◽  
Nonalcoholic Fatty Liver ◽  
Expression Of Genes ◽  
Hepatic Fat ◽  
Underlying Mechanisms

AbstractIn obese adults, nonalcoholic fatty liver disease (NAFLD) is accompanied by multiple metabolic dysfunctions. Although upregulated hepatic fatty acid synthesis has been identified as a crucial mediator of NAFLD development, the underlying mechanisms are yet to be elucidated. In this study, we reported upregulated expression of gene related to anergy in lymphocytes (GRAIL) in the livers of humans and mice with hepatic steatosis. Grail ablation markedly alleviated the high-fat diet-induced hepatic fat accumulation and expression of genes related to the lipid metabolism, in vitro and in vivo. Conversely, overexpression of GRAIL exacerbated lipid accumulation and enhanced the expression of lipid metabolic genes in mice and liver cells. Our results demonstrated that Grail regulated the lipid accumulation in hepatic steatosis via interaction with sirtuin 1. Thus, Grail poses as a significant molecular regulator in the development of NAFLD.

Oestrogen Receptor α in the Heart is Critical for Protection Against Systemic Obesity in Female Mice

2021 ◽  
Vol 30 ◽  
pp. S123
Author(s):  
Y. Tham ◽  
B. Bernardo ◽  
L. Woon ◽  
S. Yildiz ◽  
C. Tai ◽  
...  
Keyword(s):  
Oestrogen Receptor ◽  
Female Mice ◽  
Oestrogen Receptor Α
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