scholarly journals Physical exercise prepartum to support metabolic adaptation in the transition period of dairy cattle: A proof of concept

2020 ◽  
Vol 104 (3) ◽  
pp. 790-801
Author(s):  
Roselinde M. A. Goselink ◽  
Jan Thomas Schonewille ◽  
Gert Duinkerken ◽  
Wouter H. Hendriks
Keyword(s):  
Physical Exercise ◽  
Dairy Cattle ◽  
Transition Period ◽  
Metabolic Adaptation ◽  
Proof Of Concept

scholarly journals Use of a direct-fed microbial product as a supplement during the transition period in dairy cattle

2014 ◽  
Vol 97 (11) ◽  
pp. 7102-7114 ◽  
Author(s):  
O. AlZahal ◽  
H. McGill ◽  
A. Kleinberg ◽  
J.I. Holliday ◽  
I.K. Hindrichsen ◽  
...  
Keyword(s):  
Dairy Cattle ◽  
Transition Period ◽  
Microbial Product

Relevant aspects of dietary n-3 polyunsaturated fatty acids in the adaptation of dairy cattle to the transition period

2020 ◽  
pp. 104346
Author(s):  
E. Angeli ◽  
D. Barcarolo ◽  
L. Ribas ◽  
B.E. Marelli ◽  
P.M. Roskopf ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Dairy Cattle ◽  
Polyunsaturated Fatty Acids ◽  
Transition Period

scholarly journals Oxidative stress index (OSi) as a new tool to assess redox status in dairy cattle during the transition period

animal ◽  
2013 ◽  
Vol 7 (8) ◽  
pp. 1374-1378 ◽  
Author(s):  
A. Abuelo ◽  
J. Hernández ◽  
J.L. Benedito ◽  
C. Castillo
Keyword(s):  
Oxidative Stress ◽  
Dairy Cattle ◽  
Transition Period ◽  
Redox Status ◽  
Stress Index ◽  
Oxidative Stress Index

scholarly journals HEPATO-RENAL ALTERATIONS IN DAIRY CATTLE WITH SUBCLINICAL KETOSIS DURING TRANSITION PERIOD

2017 ◽  
Vol 18 (1) ◽  
pp. 155-163
Author(s):  
Mohamed Youssef ◽  
Maged El-Ashker ◽  
Marwa Younis
Keyword(s):  
Dairy Cattle ◽  
Transition Period ◽  
Subclinical Ketosis

scholarly journals Mismatch of Glucose Allocation between Different Life Functions in the Transition Period of Dairy Cows

Animals ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1028 ◽  
Author(s):  
Jonas Habel ◽  
Albert Sundrum
Keyword(s):  
Immune Cell ◽  
Transition Period ◽  
Receptor Expression ◽  
Whole Body ◽  
Metabolic Adaptation ◽  
Immune Functions ◽  
Somatotropic Axis ◽  
Cell Functions ◽  
Glucocorticoid Response ◽  
Proliferation And Differentiation

Immune cell functions such as phagocytosis and synthesis of immunometabolites, as well as immune cell survival, proliferation and differentiation, largely depend on an adequate availability of glucose by immune cells. During inflammation, the glucose demands of the immune system may increase to amounts similar to those required for high milk yields. Similar metabolic pathways are involved in the adaptation to both lactation and inflammation, including changes in the somatotropic axis and glucocorticoid response, as well as adipokine and cytokine release. They affect (i) cell growth, proliferation and activation, which determines the metabolic activity and thus the glucose demand of the respective cells; (ii) the overall availability of glucose through intake, mobilization and gluconeogenesis; and (iii) glucose uptake and utilization by different tissues. Metabolic adaptation to inflammation and milk synthesis is interconnected. An increased demand of one life function has an impact on the supply and utilization of glucose by competing life functions, including glucose receptor expression, blood flow and oxidation characteristics. In cows with high genetic merits for milk production, changes in the somatotropic axis affecting carbohydrate and lipid metabolism as well as immune functions are profound. The ability to cut down milk synthesis during periods when whole-body demand exceeds the supply is limited. Excessive mobilization and allocation of glucose to the mammary gland are likely to contribute considerably to peripartal immune dysfunction.

scholarly journals Lysosomal amino acid transporters as key players in inflammatory diseases

2021 ◽  
Author(s):  
Noriko Toyama-Sorimachi ◽  
Toshihiko Kobayashi
Keyword(s):  
Signal Transduction ◽  
Amino Acid ◽  
Immune Cells ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Metabolic Adaptation ◽  
Amino Acid Transporters ◽  
Proof Of Concept ◽  
Immune Mediated ◽  
Solute Carrier

Abstract Controlling inflammation can alleviate immune-mediated, lifestyle-related and neurodegenerative diseases. The endolysosome system plays critical roles in inflammatory responses. Endolysosomes function as signal transduction hubs to convert various environmental danger signals into gene expression, enabling metabolic adaptation of immune cells and efficient orchestration of inflammation. Solute carrier family 15 member 3 (SLC15A3) and member 4 (SLC15A4) are endolysosome-resident amino acid transporters that are preferentially expressed in immune cells. These transporters play essential roles in signal transduction through endolysosomes, and the loss of either transporter can alleviate multiple inflammatory diseases because of perturbed endolysosome-dependent signaling events, including inflammatory and metabolic signaling. Here, we summarize the findings leading to a proof-of-concept for anti-inflammatory strategies based on targeting SLC15 transporters.

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