scholarly journals Short‐chain fatty acids inhibit bovine rumen epithelial cells proliferation via upregulation of cyclin‐dependent kinase inhibitors 1A, but not mediated by G protein‐coupled receptor 41

2019 ◽  
Vol 104 (2) ◽  
pp. 409-417 ◽  
Author(s):  
Tianyu Yang ◽  
Kang Zhan ◽  
LiLi Ning ◽  
Maocheng Jiang ◽  
Guoqi Zhao
Keyword(s):  
Fatty Acids ◽  
Epithelial Cells ◽  
G Protein ◽  
Kinase Inhibitors ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Cyclin Dependent Kinase ◽  
Bovine Rumen ◽  
G Protein Coupled ◽  
Rumen Epithelial Cells

scholarly journals Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

Diabetes ◽  
2011 ◽  
Vol 61 (2) ◽  
pp. 364-371 ◽  
Author(s):  
G. Tolhurst ◽  
H. Heffron ◽  
Y. S. Lam ◽  
H. E. Parker ◽  
A. M. Habib ◽  
...  
Keyword(s):  
Fatty Acids ◽  
G Protein ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
G Protein Coupled Receptor ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
G Protein Coupled ◽  
Chain Fatty Acids

scholarly journals G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer

2010 ◽  
Vol 128 (4) ◽  
pp. 847-856 ◽  
Author(s):  
Yong Tang ◽  
Yakun Chen ◽  
Hongmei Jiang ◽  
Gregory T. Robbins ◽  
Daotai Nie
Keyword(s):  
Fatty Acids ◽  
Colon Cancer ◽  
G Protein ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled ◽  
Chain Fatty Acids

scholarly journals The olfactory G protein-coupled receptor (Olfr-78/OR51E2) modulates the intestinal response to colitis

2020 ◽  
Vol 318 (3) ◽  
pp. C502-C513
Author(s):  
Kumar Kotlo ◽  
Arivarasu N. Anbazhagan ◽  
Shubha Priyamvada ◽  
Dulari Jayawardena ◽  
Anoop Kumar ◽  
...  
Keyword(s):  
Fatty Acids ◽  
G Protein ◽  
Olfactory Receptor ◽  
Intestinal Inflammation ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
G Protein Coupled Receptor ◽  
Trinitrobenzenesulfonic Acid ◽  
G Protein Coupled ◽  
Chain Fatty Acids

Olfactory receptor-78 (Olfr-78) is a recently identified G protein-coupled receptor activated by short-chain fatty acids acetate and propionate. A suggested role for this receptor exists in the prostate where it may influence chronic inflammatory response leading to intraepithelial neoplasia. Olfr-78 has also been shown to be expressed in mouse colon. Short-chain fatty acids and their receptors are well known to modulate inflammation in the gut. Considering this possibility, we first explored if colitis regulated Olfr-78 expression in the gut, where we observed a significant reduction in the expression of Olfr-78 transcript in mouse models of dextran sodium sulfate (DSS)- and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis. To more directly test this, mice deficient in Olfr-78 were administered with DSS in water for 7 days and were found to have increased expression of IL-1β and inflammatory signs in colon compared with control mice. Next, we explored the expression of its human counterpart olfactory receptor family 51, subfamily E, member 2 (OR51E2) in human intestinal samples and observed that it was in fact also expressed in human colon samples. RNA sequence analysis revealed significant changes in the genes involved in infection, immunity, inflammation, and colorectal cancer between wild-type and Olfr-78 knockout mice. Collectively, our findings show that Olfr-78 is highly expressed in colon and downregulated in DSS- and TNBS-induced colitis, and DSS-treated Olfr-78 null mice had increased colonic expression of cytokine RNA levels, suggesting a potential role for this receptor in intestinal inflammation. Future investigations are needed to understand how Olfr-78/OR51E2 in both mouse and human intestine modulates gastrointestinal pathophysiology.

scholarly journals Author Correction: Bidirectional regulatory potentials of short-chain fatty acids and their G-protein-coupled receptors in autoimmune neuroinflammation

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jeongho Park ◽  
Qin Wang ◽  
Qi Wu ◽  
Yang Mao-Draayer ◽  
Chang H. Kim
Keyword(s):  
Fatty Acids ◽  
G Protein ◽  
Short Chain Fatty Acids ◽  
G Protein Coupled Receptors ◽  
Short Chain ◽  
G Protein Coupled ◽  
Chain Fatty Acids

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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