Expression of genes related to liver fatty acid metabolism in fat‐tailed and thin‐tailed lambs during negative and positive energy balances

2018 ◽  
Author(s):  
Hossein Zakariapour Bahnamiri ◽  
Mahdi Ganjkhanlou ◽  
Abolfazl Zali ◽  
Mostafa Sadeghi ◽  
Hossein Moradi Shahrbabak ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Positive Energy ◽  
Liver Fatty Acid ◽  
Expression Of Genes ◽  
Energy Balances

scholarly journals Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice

2006 ◽  
Vol 27 (3) ◽  
pp. 187-200 ◽  
Author(s):  
Colin Selman ◽  
Nicola D. Kerrison ◽  
Anisha Cooray ◽  
Matthew D. W. Piper ◽  
Steven J. Lingard ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
Caloric Restriction ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Proton Nuclear Magnetic Resonance ◽  
Cellular Transport ◽  
Expression Of Genes ◽  
Transcriptional Changes

Caloric restriction (CR) increases healthy life span in a range of organisms. The underlying mechanisms are not understood but appear to include changes in gene expression, protein function, and metabolism. Recent studies demonstrate that acute CR alters mortality rates within days in flies. Multitissue transcriptional changes and concomitant metabolic responses to acute CR have not been described. We generated whole genome RNA transcript profiles in liver, skeletal muscle, colon, and hypothalamus and simultaneously measured plasma metabolites using proton nuclear magnetic resonance in mice subjected to acute CR. Liver and muscle showed increased gene expressions associated with fatty acid metabolism and a reduction in those involved in hepatic lipid biosynthesis. Glucogenic amino acids increased in plasma, and gene expression for hepatic gluconeogenesis was enhanced. Increased expression of genes for hormone-mediated signaling and decreased expression of genes involved in protein binding and development occurred in hypothalamus. Cell proliferation genes were decreased and cellular transport genes increased in colon. Acute CR captured many, but not all, hepatic transcriptional changes of long-term CR. Our findings demonstrate a clear transcriptional response across multiple tissues during acute CR, with congruent plasma metabolite changes. Liver and muscle switched gene expression away from energetically expensive biosynthetic processes toward energy conservation and utilization processes, including fatty acid metabolism and gluconeogenesis. Both muscle and colon switched gene expression away from cellular proliferation. Mice undergoing acute CR rapidly adopt many transcriptional and metabolic changes of long-term CR, suggesting that the beneficial effects of CR may require only a short-term reduction in caloric intake.

Liver fatty acid metabolism associations with reproductive performance of dairy cattle

2019 ◽  
Vol 208 ◽  
pp. 106104 ◽  
Author(s):  
Emmanuel Angeli ◽  
Fernanda Mariel Rodríguez ◽  
Florencia Rey ◽  
Gonzalo Santiago ◽  
Valentina Matiller ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Dairy Cattle ◽  
Fatty Acid Metabolism ◽  
Reproductive Performance ◽  
Acid Metabolism ◽  
Liver Fatty Acid

Ingested cocoa can prevent high-fat diet-induced obesity by regulating the expression of genes for fatty acid metabolism

Nutrition ◽  
2005 ◽  
Vol 21 (5) ◽  
pp. 594-601 ◽  
Author(s):  
Naoko Matsui ◽  
Ryoichi Ito ◽  
Eisaku Nishimura ◽  
Mariko Yoshikawa ◽  
Masatoshi Kato ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
High Fat Diet ◽  
Acid Metabolism ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Expression Of Genes

Growth effects on the insulin alteration of chang liver fatty acid metabolism

Life Sciences ◽  
1973 ◽  
Vol 13 (4) ◽  
pp. 377-382
Author(s):  
Steven H. Quarfordt ◽  
Raymond U ◽  
Lazlo Jakoi ◽  
Anne Nathans ◽  
Helen Hilderman
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Liver Fatty Acid ◽  
Growth Effects ◽  
Chang Liver

Dietary L‐carnitine affects the expression of genes involved in apoptosis and fatty acid metabolism in rooster testes

Andrologia ◽  
2020 ◽  
Vol 52 (11) ◽  
Author(s):  
Vahid Mohammadi ◽  
Seyed Davood Sharifi ◽  
Mohsen Sharafi ◽  
Abdollah Mohammadi‐Sangcheshmeh ◽  
Elham Abedheydari ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Expression Of Genes

Modification of liver fatty acid metabolism in mice by n − 3 and n − 6 Δ6-desaturase substrates and products

1991 ◽  
Vol 1082 (3) ◽  
pp. 319-327 ◽  
Author(s):  
Yung-Sheng Huang ◽  
Rick S. Smith ◽  
Peter R. Redden ◽  
Richard C. Cantriii ◽  
David F. Horrobin
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Liver Fatty Acid ◽  
Δ6 Desaturase

scholarly journals Correlation between increased atrial expression of genes related to fatty acid metabolism and autophagy in patients with chronic atrial fibrillation

2019 ◽  
Author(s):  
Yasushige Shingu ◽  
Shingo Takada ◽  
Takashi Yokota ◽  
Ryosuke Shirakawa ◽  
Akira Yamada ◽  
...  
Keyword(s):  
Gene Expression ◽  
Atrial Fibrillation ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Right Atrial ◽  
Fatty Acid Transport ◽  
Acid Uptake ◽  
Fatty Acid Binding ◽  
Expression Of Genes

AbstractAtrial metabolic disturbance contributes to the onset and development of atrial fibrillation (AF). Autophagy plays a role in maintaining the cellular energy balance. We examined whether the altered atrial expression of genes related to fatty acid metabolism is linked to that related to autophagy in chronic AF. Right atrial tissue was obtained during heart surgery from 51 patients with sinus rhythm (SR, n=38) or chronic AF (n=13). Preoperative fasting serum free-fatty-acid levels were significantly higher in the AF patients. The atrial gene expression of fatty acid binding protein 3 (FABP3), which is involved in the cells’ fatty acid uptake and intracellular fatty acid transport, was significantly increased in AF patients compared to SR patients; in the SR patients it was positively correlated with the right atrial diameter and intra-atrial EMD, parameters of structural and electrical atrial remodeling that was evaluated by an echocardiography. In contrast, the two groups’ atrial contents of diacylglycerol (DAG), a toxic fatty acid metabolite, were comparable. Importantly, the atrial gene expression of microtubule-associated protein light chain 3 (LC3) was significantly increased in the AF patients, and autophagy-related genes including LC3 were positively correlated with the atrial expression of FABP3. In conclusion, in chronic AF patients, the atrial expression of FABP3 was upregulated in association with autophagy-related genes without altered atrial DAG content. Our findings may support the hypothesis that dysregulated cardiac fatty acid metabolism contributes to the progression of AF and induction of autophagy has a cardioprotective effect against cardiac lipotoxicity in chronic AF.

scholarly journals Correlation between increased atrial expression of genes related to fatty acid metabolism and autophagy in patients with chronic atrial fibrillation

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0224713 ◽  
Author(s):  
Yasushige Shingu ◽  
Shingo Takada ◽  
Takashi Yokota ◽  
Ryosuke Shirakawa ◽  
Akira Yamada ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Chronic Atrial Fibrillation ◽  
Expression Of Genes
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