scholarly journals Vitamin D metabolism in growing pigs: influence of UVB irradiation and dietary vitamin D supply on calcium homeostasis, its regulation and bone metabolism

2017 ◽  
Vol 101 ◽  
pp. 79-94 ◽  
Author(s):  
E. Kolp ◽  
M. R. Wilkens ◽  
W. Pendl ◽  
B. Eichenberger ◽  
A. Liesegang
2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 365-365
Author(s):  
Cai-Xia Zhang

Abstract Objectives Vitamin D has anticarcinogenic properties. Vitamin D metabolism-related gene polymorphisms can influence vitamin D levels and its impact on carcinogenesis. This study aimed to explore the independent and combined effects of dietary vitamin D and vitamin D metabolism-related gene polymorphisms on colorectal cancer risk in a Chinese population. Methods Incident cases with histologically confirmed colorectal cancer, and sex and age-matched controls were recruited in this ongoing case-control study. Of them, 488 cases and 496 controls were both successfully interviewed and collected blood samples. Vitamin D intake was assessed by a validated food frequency questionnaire. Genotyping was performed for CYP2R1 rs10741657, CYP2R1 rs12794714, CYP24A1 rs6013897, CYP24A1 rs6068816, CYP27B1 rs4646536 and GC rs7041 by using an improved multiplex ligation detection reaction (iMLDR) technique. Unconditional multivariable logistic regression was used to calculate odds ratio (OR) and 95% confidence interval (CI) after adjusting for various confounders. Results Higher intake of dietary vitamin D was associated with 47% reduction in colorectal cancer with OR of 0.53 (95% CI: 0.34, 0.82) for the highest quartile (vs. lowest quartile) intake. Compared with persons with CYP24A1 rs6068816 CC genotype, lower risk of colorectal cancer was observed among carriers of TT genotype (OR = 0.57, 95%CI 0.36, 0.89). No significant association was found between CYP2R1 rs10741657, CYP2R1 rs12794714, CYP24A1 rs6013897, CYP27B1 rs4646536, GC rs7041 and colorectal cancer risk. No significant interaction was observed between dietary vitamin D intake and six examined single nucleotide polymorphisms on the risk of colorectal cancer. Conclusions Our study supports a protective effect of high intake of dietary vitamin D on colorectal cancer. CYP24A1 rs6068816 TT genotype was significantly associated with a decreased risk of colorectal cancer. No interaction was observed between dietary vitamin D intake and six examined single nucleotide polymorphisms in a Chinese population. Funding Sources Guangdong Natural Science Foundation (No: 2019A1515011931).


2011 ◽  
Vol 89 (6) ◽  
pp. 1844-1852 ◽  
Author(s):  
A.-K. M. Witschi ◽  
A. Liesegang ◽  
S. Gebert ◽  
G. M. Weber ◽  
C. Wenk

The Lancet ◽  
1979 ◽  
Vol 314 (8150) ◽  
pp. 1021 ◽  
Author(s):  
D.E.M Lawson

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0140370 ◽  
Author(s):  
Christopher C. Gibson ◽  
Chadwick T. Davis ◽  
Weiquan Zhu ◽  
Jay A. Bowman-Kirigin ◽  
Ashley E. Walker ◽  
...  

2021 ◽  
pp. jim-2020-001645
Author(s):  
Laura D Carbone ◽  
Karen Johnson ◽  
Joseph C Larson ◽  
Fridtjof Thomas ◽  
Jean Wactawski-Wende ◽  
...  

The relationship between vitamin D and glaucoma is controversial. The objective of this study was to examine women from the Women’s Health Initiative (WHI) to determine if there is an association between vitamin D and incident glaucoma in postmenopausal women. We examined the association between dietary vitamin D intake, vitamin D supplements and serum 25 hydroxyvitamin D (25(OH)D) levels and the risk of developing glaucoma. 143,389 postmenopausal women from the WHI including a subset with serum 25(OH) D measurements were examined to determine the association of dietary, supplemental and serum levels of vitamin D to the development of glaucoma. Dietary intakes of vitamin D, use of vitamin D supplements and serum levels of 25(OH) D were predictors examined for the main outcome of incident glaucoma. In multivariable models adjusted for demographic, clinical variables and medication use, dietary vitamin D, vitamin D supplements, total vitamin D intake (diet plus supplements) and serum 25 (OH) D measurements were not significantly associated with incident glaucoma. In the CaD placebo-controlled intervention clinical trial, there was also no association in the active intervention arm with glaucoma. We conclude that dietary vitamin D intake, supplements and serum levels are not significantly related to the risk of developing glaucoma in postmenopausal women.


2021 ◽  
pp. 1-7
Author(s):  
Rifat Ullah Khan ◽  
Shabana Naz ◽  
Hammad Ullah ◽  
Nazir Ahmad Khan ◽  
Vito Laudadio ◽  
...  

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