Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin‐proficient C57BL/6J congenic mice

2021 ◽  
Author(s):  
Chongyang Zhang ◽  
Shannon J. Clough ◽  
Ekue B. Adamah‐Biassi ◽  
Michele H. Sveinsson ◽  
Anthony J. Hutchinson ◽  
...  
Keyword(s):  
Congenic Mice ◽  
Rhythmic Behaviors ◽  
Endogenous Melatonin

Melatonin: Protection of the Intervertebral Disc

2019 ◽  
Vol 2 (3) ◽  
pp. 1-9
Author(s):  
Russel J Reiter ◽  
Sergio Rosales-Corral ◽  
Ramaswamy Sharma
Keyword(s):  
Intervertebral Disc ◽  
Molecular Mechanisms ◽  
Intervertebral Discs ◽  
Lumbar Pain ◽  
Low Back ◽  
Work Time ◽  
Protective Actions ◽  
Aging Populations ◽  
Definition Of ◽  
Endogenous Melatonin

     Low back pain (lumbar pain) due to injury of or damage to intervertebral discs is common in all societies.  The loss of work time as a result of this problem is massive.  Recent research suggests that melatonin may prevent or counteract intervertebral disc damage. This may be especially relevant in aging populations given that endogenous melatonin, in most individuals, dwindles with increasing age. The publications related to melatonin and its protection of the intervertebral disc are reviewed herein, including definition of some molecular mechanisms that account for melatonin’s protective actions. 

Melatonin in pediatric neurology

ORL ro ◽  
2016 ◽  
Vol 4 (1) ◽  
pp. 56-59
Author(s):  
Raluca Ioana Teleanu ◽  
Magdalena Sandu ◽  
Eugenia Roza
Keyword(s):  
European Union ◽  
Food Safety ◽  
Sleep Onset ◽  
Sleep Onset Latency ◽  
The European Union ◽  
Onset Latency ◽  
Entire Life ◽  
Light Darkness ◽  
Efficacy Studies ◽  
Endogenous Melatonin

Melatonin  is a hormone produced by the pineal gland during the night, as a response to the light-darkness variation. The endogenous melatonin levels have a cyclic evolution throughout the entire life. Various roles have been cited such as the in utero developement of the fetus through its action on the placenta, neurons and glial cells, a major role in the regulation of the cyrcadian rhythm, antioxidative, antiinflammatory roles, as well as celullar and umoral immunity modulation. In the European Union, exogenous melatonin has been evaluated by the European Food Safety Authority (EFSA) for reducing sleep onset latency and the conclusion was that it has efficacy studies in this regard.  

Endogenous melatonin and sleep in individuals with Rare Genetic Neurodevelopmental Disorders (RGND): A systematic review

2021 ◽  
Vol 57 ◽  
pp. 101433
Author(s):  
Emma C. Woodford ◽  
Laurie McLay ◽  
Karyn G. France ◽  
Neville M. Blampied ◽  
Rosina Gibbs ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neurodevelopmental Disorders ◽  
Endogenous Melatonin

scholarly journals Clinical Chemistry of Congenic Mice with Quantitative Trait Loci for Predicted Responses to Trypanosoma congolense Infection

2009 ◽  
Vol 77 (9) ◽  
pp. 3948-3957 ◽  
Author(s):  
Birgit Rathkolb ◽  
Harry A. Noyes ◽  
Andy Brass ◽  
Paul Dark ◽  
Helmut Fuchs ◽  
...  
Keyword(s):  
Survival Time ◽  
Clinical Chemistry ◽  
Inbred Mice ◽  
Protozoan Parasite ◽  
Physiological Effect ◽  
Trypanosoma Congolense ◽  
Survival Times ◽  
Inflammatory Reactions ◽  
Congenic Mice ◽  
Trait Loci

ABSTRACT Trypanosoma congolense is a protozoan parasite that causes severe diseases in livestock. Three major quantative trait loci (QTL), Tir1, Tir2, and Tir3, control the survival time of mice after infection with T. congolense. Congenic mice carrying the C57BL/6 resistance alleles on the A/J background were developed for each of these loci. The congenic mice were used to physically map the regions containing the QTL gene(s) and to investigate the physiological effect of each locus. Clinical chemistry data for infected A/J, C57BL/6, and BALB/c mice were obtained for 15 analytes at five time points. Congenic mice were assessed for survival, parasitemia, and anemia as well as seven clinical-chemical analytes. The survival times were significantly increased in the Tir1 and Tir2 mice but not Tir3 congenic mice. The survival time of the parental inbred mice correlated negatively with parasitemia but positively with alanine aminotransferase activities in serum, suggesting that inflammatory reactions in the liver had a beneficial effect possibly associated with reduced parasitemia. However, there was no difference in parasitemia or liver enzyme activities of Tir1 and Tir2 congenic mice relative to their controls, showing that survival, parasitemia, and degree of liver damage are not associated with each other, despite the correlation in the parental lines. These data suggest that the congenic loci affect survival but do not affect control of parasite number. They may therefore act by limiting the pathological consequences of T. congolense infection.

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