A hypothetical role for autophagy during the day/night rhythm regulated melatonin synthesis in the rat pineal gland

2021 ◽  
Author(s):  
Wei Ge ◽  
Zi‐Hui Yan ◽  
Lu Wang ◽  
Shao‐Jing Tan ◽  
Jing Liu ◽  
...  
Keyword(s):  
Pineal Gland ◽  
Melatonin Synthesis ◽  
Rat Pineal Gland

Failure to stimulate melatonin synthesis in the rat pineal gland with an adenosine analog

1992 ◽  
Vol 17 (2-3) ◽  
pp. 249-254 ◽  
Author(s):  
M NORDIO ◽  
D CONTE ◽  
K NONAKA ◽  
R REITER ◽  
A ISIDORI
Keyword(s):  
Pineal Gland ◽  
Melatonin Synthesis ◽  
Rat Pineal Gland ◽  
Adenosine Analog

scholarly journals Chronic treatment with dexamethasone alters clock gene expression and melatonin synthesis in rat pineal gland at night

2018 ◽  
Vol Volume 10 ◽  
pp. 203-215 ◽  
Author(s):  
Daniela Meneses-Santos ◽  
Daniella do Carmo Buonfiglio ◽  
Rodrigo Antonio Peliciari-Garcia ◽  
Angela Maria Ramos-Lobo ◽  
Divanízia do Nascimento Souza ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pineal Gland ◽  
Clock Gene ◽  
Chronic Treatment ◽  
Melatonin Synthesis ◽  
Clock Gene Expression ◽  
Rat Pineal Gland

scholarly journals Melatonin Synthesis: Acetylserotonin O-Methyltransferase (ASMT) Is Strongly Expressed in a Subpopulation of Pinealocytes in the Male Rat Pineal Gland

Endocrinology ◽  
2016 ◽  
Vol 157 (5) ◽  
pp. 2028-2040 ◽  
Author(s):  
Martin F. Rath ◽  
Steven L. Coon ◽  
Fernanda G. Amaral ◽  
Joan L. Weller ◽  
Morten Møller ◽  
...  
Keyword(s):  
Pineal Gland ◽  
Male Rat ◽  
Melatonin Synthesis ◽  
Rat Pineal Gland

scholarly journals Effects of Diazepam Administration on Melatonin Synthesis in the Rat Pineal Gland in Vivo.

1991 ◽  
Vol 39 (10) ◽  
pp. 2674-2676 ◽  
Author(s):  
Hiroyuki WAKABAYASHI ◽  
Kenji SHIMADA ◽  
Tetsuo SATOH
Keyword(s):  
Pineal Gland ◽  
Melatonin Synthesis ◽  
Rat Pineal Gland

scholarly journals Leptin Modulates Norepinephrine-Mediated Melatonin Synthesis in Cultured Rat Pineal Gland

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Rodrigo Antonio Peliciari-Garcia ◽  
Jéssica Andrade-Silva ◽  
José Cipolla-Neto ◽  
Carla Roberta de Oliveira Carvalho
Keyword(s):  
Pineal Gland ◽  
Leptin Receptor ◽  
Pineal Melatonin ◽  
Melatonin Synthesis ◽  
Inducible Camp Early Repressor ◽  
Per Se ◽  
Isoform B ◽  
Rat Pineal Gland

Pineal melatonin synthesis can be modulated by many peptides, including insulin. Because melatonin appears to alter leptin synthesis, in this work we aimed to investigate whether leptin would have a role on norepinephrine- (NE-)mediated melatonin synthesis in cultured rat pineal glands. According to our data, cultured rat pineal glands express leptin receptor isoform b (Ob-Rb). Pineal expression ofOb-RbmRNA was also observedin vivo. Administration of leptin (1 nM) associated with NE (1 µM) reduced melatonin content as well as arylalkylamine-N-acetyl transferase (AANAT) activity and expression in cultured pineal glands. Leptin treatment per se induced the expression of STAT3 in cultured pineal glands, but STAT3 does not participate in the leptin modulation of NE-mediated pineal melatonin synthesis. In addition, the expression of inducible cAMP early repressor (ICER) was further induced by leptin challenge when associated with NE. In conclusion, leptin inhibition of pineal melatonin synthesis appears to be mediated by a reduction in AANAT activity and expression as well as by increased expression ofIcermRNA. Peptidergic signaling within the pineal gland appears to be one of the most important signals which modulates melatonin synthesis; leptin, as a member of this system, is not an exception.

Identification of insulin-regulated aminopeptidase (IRAP) in the rat pineal gland and the modulation of melatonin synthesis by angiotensin IV

2019 ◽  
Vol 1704 ◽  
pp. 40-46 ◽  
Author(s):  
Mariana Vieira Abrahão ◽  
Natália Fernanda Teixeira dos Santos ◽  
Wilson Mitsuo Tatagiba Kuwabara ◽  
Fernanda Gaspar do Amaral ◽  
Daniella do Carmo Buonfiglio ◽  
...  
Keyword(s):  
Pineal Gland ◽  
Angiotensin Iv ◽  
Melatonin Synthesis ◽  
Rat Pineal Gland

Methylcobalamin amplifies melatonin-induced circadian phase shifts by facilitation of melatonin synthesis in the rat pineal gland

1998 ◽  
Vol 795 (1-2) ◽  
pp. 98-104 ◽  
Author(s):  
Masayuki Ikeda ◽  
Makoto Asai ◽  
Takahiro Moriya ◽  
Masami Sagara ◽  
Shojiro Inoué ◽  
...  
Keyword(s):  
Pineal Gland ◽  
Phase Shifts ◽  
Circadian Phase ◽  
Melatonin Synthesis ◽  
Rat Pineal Gland
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