Binocular facilitation in light‐mediated melatonin suppression?

2019 ◽  
Vol 67 (4) ◽  
Author(s):  
Manuel Spitschan ◽  
Christian Cajochen
Keyword(s):  
Melatonin Suppression ◽  
Binocular Facilitation

scholarly journals Comment Concerning the Effects of Light Intensity on Melatonin Suppression in the Review “Light Modulation of Human Clocks, Wake, and Sleep” by A. Prayag et al.

2021 ◽  
Vol 3 (1) ◽  
pp. 181-188
Author(s):  
Peter Bracke ◽  
Eowyn Van de Putte ◽  
Wouter R. Ryckaert
Keyword(s):  
Phase Shift ◽  
Light Intensity ◽  
Dose Response ◽  
Light Modulation ◽  
Response Curves ◽  
Practical Applications ◽  
Circadian Phase ◽  
Melatonin Suppression ◽  
Dose Response Curves ◽  
Circadian Phase Shift

Dose-response curves for circadian phase shift and melatonin suppression in relation to white or monochromatic nighttime illumination can be scaled to melanopic weighed illumination for normally constricted pupils, which makes them easier to interpret and compare. This is helpful for a practical applications.

Impact of sex and age on light-induced melatonin suppression in the evening

2017 ◽  
Vol 40 ◽  
pp. e257-e258
Author(s):  
T. Penzel ◽  
L. Franke ◽  
A. Nasert ◽  
H. Piazena ◽  
B. Weller ◽  
...  
Keyword(s):  
Melatonin Suppression

scholarly journals Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways

2018 ◽  
Vol 25 (1) ◽  
pp. 107327481881290 ◽  
Author(s):  
A. E. Zubidat ◽  
B. Fares ◽  
F. Fares ◽  
A. Haim
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Tumor Growth ◽  
Short Wavelength ◽  
Global Dna Methylation ◽  
Artificial Light ◽  
Dna Hypomethylation ◽  
Light At Night ◽  
Cancer Burden ◽  
Melatonin Suppression

Lighting technology is rapidly advancing toward shorter wavelength illuminations that offer energy-efficient properties. Along with this advantage, the increased use of such illuminations also poses some health challenges, particularly breast cancer progression. Here, we evaluated the effects of artificial light at night (ALAN) of 4 different spectral compositions (500-595 nm) at 350 Lux on melatonin suppression by measuring its urine metabolite 6-sulfatoxymelatonin, global DNA methylation, tumor growth, metastases formation, and urinary corticosterone levels in 4T1 breast cancer cell-inoculated female BALB/c mice. The results revealed an inverse dose-dependent relationship between wavelength and melatonin suppression. Short wavelength increased tumor growth, promoted lung metastases formation, and advanced DNA hypomethylation, while long wavelength lessened these effects. Melatonin treatment counteracted these effects and resulted in reduced cancer burden. The wavelength suppression threshold for melatonin-induced tumor growth was 500 nm. These results suggest that short wavelength increases cancer burden by inducing aberrant DNA methylation mediated by the suppression of melatonin. Additionally, melatonin suppression and global DNA methylation are suggested as promising biomarkers for early diagnosis and therapy of breast cancer. Finally, ALAN may manifest other physiological responses such as stress responses that may challenge the survival fitness of the animal under natural environments.

scholarly journals Spectral Tuning of White Light Allows for Strong Reduction in Melatonin Suppression without Changing Illumination Level or Color Temperature

2018 ◽  
Vol 33 (4) ◽  
pp. 420-431 ◽  
Author(s):  
Jan L. Souman ◽  
Tobias Borra ◽  
Iris de Goijer ◽  
Luc J. M. Schlangen ◽  
Björn N. S. Vlaskamp ◽  
...  
Keyword(s):  
White Light ◽  
High Power ◽  
Spectral Power ◽  
Monochromatic Light ◽  
Action Spectrum ◽  
Color Temperature ◽  
Light Spectrum ◽  
Melatonin Suppression ◽  
Dim Light ◽  
Melatonin Production

Studies with monochromatic light stimuli have shown that the action spectrum for melatonin suppression exhibits its highest sensitivity at short wavelengths, around 460 to 480 nm. Other studies have demonstrated that filtering out the short wavelengths from white light reduces melatonin suppression. However, this filtering of short wavelengths was generally confounded with reduced light intensity and/or changes in color temperature. Moreover, it changed the appearance from white light to yellow/orange, rendering it unusable for many practical applications. Here, we show that selectively tuning a polychromatic white light spectrum, compensating for the reduction in spectral power between 450 and 500 nm by enhancing power at even shorter wavelengths, can produce greatly different effects on melatonin production, without changes in illuminance or color temperature. On different evenings, 15 participants were exposed to 3 h of white light with either low or high power between 450 and 500 nm, and the effects on salivary melatonin levels and alertness were compared with those during a dim light baseline. Exposure to the spectrum with low power between 450 and 500 nm, but high power at even shorter wavelengths, did not suppress melatonin compared with dim light, despite a large difference in illuminance (175 vs. <5 lux). In contrast, exposure to the spectrum with high power between 450 and 500 nm (also 175 lux) resulted in almost 50% melatonin suppression. For alertness, no significant differences between the 3 conditions were observed. These results open up new opportunities for lighting applications that allow for the use of electrical lighting without disturbance of melatonin production.

scholarly journals Effects of Exposure to Intermittent versus Continuous Red Light on Human Circadian Rhythms, Melatonin Suppression, and Pupillary Constriction

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96532 ◽  
Author(s):  
Ivan Ho Mien ◽  
Eric Chern-Pin Chua ◽  
Pauline Lau ◽  
Luuan-Chin Tan ◽  
Ivan Tian-Guang Lee ◽  
...  
Keyword(s):  
Circadian Rhythms ◽  
Red Light ◽  
Melatonin Suppression ◽  
Human Circadian Rhythms ◽  
Pupillary Constriction
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