Inhibition of SERPINA3N‐dependent neuroinflammation is essential for melatonin to ameliorate trimethyltin chloride–induced neurotoxicity

2019 ◽  
Vol 67 (3) ◽  
Author(s):  
Yu Xi ◽  
Mengyu Liu ◽  
Shuzhen Xu ◽  
Huihui Hong ◽  
Mengyan Chen ◽  
...  
Keyword(s):  
Trimethyltin Chloride

Spindle-Inhibiting Effects of Organotin Compounds: Effects of Trimethyltin on Chromosome Length

1990 ◽  
Vol 17 (3) ◽  
pp. 195-198
Author(s):  
Klaus Gjervig Jensen ◽  
Ole Andersen ◽  
Mogens Rønne
Keyword(s):  
Exposure Time ◽  
Industrial Applications ◽  
Chromosome Length ◽  
Peripheral Lymphocyte ◽  
Organotin Compounds ◽  
Lymphocyte Cultures ◽  
Trimethyltin Chloride ◽  
Industrial Settings ◽  
Spindle Function ◽  
Human Peripheral Lymphocyte

Organotin compounds have a number of industrial applications, and human exposures occur in various industrial settings. The present study reports effects of trimethyltin chloride (TMT) on chromosome length in asynchronous human peripheral lymphocyte cultures. The results demonstrate dose-related and exposure time-related reductions in average chromosome length. Induction of supercontraction indicates that TMT is a powerful inhibitor of spindle function. TMT would thus be expected to be able to induce aneuploidy due to non-disjunction. This study indicates the need for more-direct investigations on the spindle-inhibiting effects of TMT and other organotin compounds.

The main mechanisms of trimethyltin chloride-induced neurotoxicity: Energy metabolism disorder and peroxidation damage

2021 ◽  
Vol 345 ◽  
pp. 67-76
Author(s):  
Zhenzhong Liu ◽  
Jiaqi Lv ◽  
Zhuangyu Zhang ◽  
Bo Wang ◽  
Lili Duan ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Metabolism Disorder ◽  
Trimethyltin Chloride ◽  
Energy Metabolism Disorder

scholarly journals Effect of Trimethyltin Chloride on Slow Vacuolar (SV) Channels in Vacuoles from Red Beet (Beta vulgaris L.) Taproots

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0136346 ◽  
Author(s):  
Zenon Trela ◽  
Zbigniew Burdach ◽  
Agnieszka Siemieniuk ◽  
Stanisław Przestalski ◽  
Waldemar Karcz
Keyword(s):  
Beta Vulgaris ◽  
Red Beet ◽  
Sv Channels ◽  
Trimethyltin Chloride

scholarly journals catena-Poly[[trimethyltin(IV)]-μ-methylphenylphosphinato-κ2O:O′]

IUCrData ◽  
2017 ◽  
Vol 2 (10) ◽  
Author(s):  
Chunhua Fu ◽  
Rufen Zhang ◽  
Shaoliang Zhang
Keyword(s):  
Solid State ◽  
Coordination Polymer ◽  
Title Compound ◽  
Sodium Ethoxide ◽  
Chain Structure ◽  
Polymeric Chain ◽  
One Dimensional ◽  
Trigonal Bipyramidal ◽  
Trimethyltin Chloride ◽  
Distorted Trigonal Bipyramidal

A new trimethyltin(IV) coordination polymer, [Sn(CH3)3(C7H8O2P)], has been prepared by treatment of methylphenylphosphinic acid and trimethyltin chloride with sodium ethoxide in methanol. In the solid state, the title compound adopts an infinite one-dimensional polymeric chain structure with each SnIVatom adopting a distorted trigonal–bipyramidal geometry.

The synthesis, Mössbauer and vibrational spectra of some triorganotin derivatives of phosphorus oxyacids

1976 ◽  
Vol 54 (14) ◽  
pp. 2184-2192 ◽  
Author(s):  
T. Chivers ◽  
J. H. G. Van Roode ◽  
J. N. Ruddick ◽  
J. R. Sams
Keyword(s):  
Oxygen Atom ◽  
Sodium Salt ◽  
Vibrational Spectra ◽  
Formula Unit ◽  
Silver Phosphate ◽  
Trigonal Bipyramidal ◽  
Bipyramidal Structure ◽  
Trimethyltin Chloride ◽  
Mössbauer Data ◽  
Derivatives Of

Trimethyltin hypophosphite, Me3SnPO2H2, bis(trimethyltin) phosphite dihydrate, (Me3Sn)2PO3H.2H2O, and bis(triphenyltin) phosphite, (Ph3Sn)2PO3H, have been obtained from the organotin chloride and aqueous solutions of the sodium salt of the corresponding phosphorus oxy-acid. (Me3Sn)2PO3H.2H2O can be dehydrated under vacuum at 25 °C, but disproportionation occurs on heating. Tris(trimethyltin) orthophosphate, (Me3Sn)3PO4, was prepared from trimethyltin chloride and silver phosphate in methanol and gave an adduct formulated as [Formula: see text] after recrystallization from 1,4-dioxane. Vibrational spectra and Mössbauer data for Me3SnPO2H2 are consistent with a trigonal bipyramidal structure in which planar Me3Sn groups are bridged symmetrically by PO2H2 groups. The Mössbauer spectra of (Me3Sn)2PO3H, (Ph3Sn)2PO3H, and (Me3Sn)2PO3H.2H2O suggest that the two tin atoms are in similar (probably pentacoordinate) environments, implying at least one three coordinate oxygen per formula unit. For (Me3Sn)3PO4, the vibrational spectra, Mössbauer data, and physical properties are consistent with a weakly associated structure in which all three tin atoms are in similar environments. It is suggested that association is achieved via the phosphoryl (P=O) oxygen atom, which is weakly coordinated to three tin atoms leading to a distortion of the tetrahedral arrangement around tin towards trigonal bipyramidal.

Graphite Intercalation Compounds with Trimethyltin Chloride

1984 ◽  
Vol 39 (6) ◽  
pp. 788-790 ◽  
Author(s):  
Robert Schlögl ◽  
Hanns-Peter Boehm
Keyword(s):  
Chemical Analysis ◽  
Uv Irradiation ◽  
Intercalation Compounds ◽  
X Ray Diffraction ◽  
Graphite Intercalation Compounds ◽  
X Ray ◽  
Graphite Intercalation ◽  
Anionic Species ◽  
Trimethyltin Chloride ◽  
Stage 1

AbstractIntercalation compounds of graphite with Sn(CH3)3Cl have been prepared by UV irradiation, in the presence of graphite, of solutions of Sn(CH3)3Cl, Sn(CH3)4, or of Sn(CH3)4 + SnCl4 in CCl4. Mixtures of stage 1, stage 2, and stage 3 compounds have been obtained. They were characterized by X-ray diffraction, 119Sn Mossbauer spectroscopy, and by chemical analysis. Apparently an oligomeric, anionic species is intercalated together with some solvent.

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