Melatonin promotes secondary hair follicle development of early postnatal cashmere goat and improves cashmere quantity and quality by enhancing antioxidant capacity and suppressing apoptosis

2019 ◽  
pp. e12569 ◽  
Author(s):  
Chun‐He Yang ◽  
Jian‐Hai Xu ◽  
Qing‐Chang Ren ◽  
Tao Duan ◽  
Fang Mo ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Hair Follicle ◽  
Follicle Development ◽  
Cashmere Goat ◽  
Hair Follicle Development

scholarly journals A single-cell transcriptome atlas during Cashmere goat hair follicle morphogenesis

2020 ◽  
Author(s):  
Wei Ge ◽  
Wei-Dong Zhang ◽  
Yue-Lang Zhang ◽  
Yu-Jie Zheng ◽  
Fang Li ◽  
...  
Keyword(s):  
Single Cell ◽  
Hair Follicle ◽  
Single Cells ◽  
Cell Lineage ◽  
Hair Follicles ◽  
Follicle Development ◽  
Cashmere Goat ◽  
Cell Fate Decisions ◽  
Molecular Profiles ◽  
Hair Follicle Development

AbstractCashmere, also known as soft gold, is produced from the secondary hair follicles in Cashmere goats and it’s therefore of significance to investigate the molecular profiles during Cashmere goat hair follicle development. However, our current understanding of the machinery underlying Cashmere goat hair follicle remains largely unexplored and researches regarding hair follicle development mainly used the mouse as a research model. To provides comprehensively understanding on the cellular heterogeneity and cell lineage cell fate decisions, we performed single-cell RNA sequencing on 19,705 single cells from induction (embryonic day 60), organogenesis (embryonic day 90) and cytodifferentiation (embryonic day 120) stages of fetus Cashmere goat dorsal skin. Unsupervised clustering analysis identified 16 cell clusters and their corresponding cell types were also unprecedentedly characterized. Based on the lineage inference, we revealed detailed molecular landscape along the dermal and epidermal cell lineage developmental pathways. Notably, by cross-species comparasion of single cell data with murine model, we revelaed conserved programs during dermal condensate fate commitment and the heterochrony development of hair follicle development between mouse and Cashmere goat were also discussed here. Our work here delineate unparalleled molecular profiles of different cell populations during Cashmere goat hair follicle morphogenesis and provide a valuable resource for identifying biomarkers during Cashmere goat hair follicle development.

scholarly journals Whole-genome sequencing of Chinese native goat offers biological insights into cashmere fiber formation

2021 ◽  
Author(s):  
Hu Han ◽  
Man-Man Yang ◽  
Dan Jiang ◽  
Xing-Ju Zhang ◽  
Qiang Wei ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Association Studies ◽  
Genetic Alterations ◽  
Fiber Formation ◽  
Luciferase Assay ◽  
Follicle Development ◽  
Cashmere Goat ◽  
Genome Wide ◽  
Hair Follicle Development ◽  
Almost All

Cashmere evolved naturally in the goat, and almost all breeds of goat can produce more or less cashmere fibers. However, the genetic alterations underlying cashmere trait selection are still unclear.We sequenced 120 Chinese native goat including two cashmere goat breeds (Ujumain, Chaidamu) and six ordinary goat breeds (Jining Gray, Matou, Guizhou Black, Jintang Black, Yunnan Black Bone, Chengdu Brown). The genome-wide selective sweep of cashmere goat and ordinary goat revealed a novel set of candidate genes as well as pathways, such as Nuclear factor kappa-B and Wnt Signaling pathways. Of them, the LHX2 gene regulating hair follicle development, was evident from the strongest selection signal when comparing the Uhumqin cashmere goat and ordinary goat. Interestingly, we identified a 582bp deletion at 367 kb upstream of LHX2 with higher frequency in cashmere goats and their ancient relatives. This mutation probably rises along the breeding procedures, and is putatively responsible for cashmere production and diameter, as revealed by association studies. Luciferase assay shows that the deletion, which acts as an insulator, restrains the expression of LHX2 by interfering its upstream enhancers.Our study discovers a novel insulator of the LHX2 involved in regulating cashmere production and diameter, which would be beneficial to understanding hair follicle development and regeneration. Our findings also provide new insights into the genetic formation of cashmere, and facilitate subsequent molecular breeding for cashmere goat improvement.

scholarly journals EDA and EDAR expression at different stages of hair follicle development in cashmere goats and effects on expression of related genes

2020 ◽  
Vol 63 (2) ◽  
pp. 461-470
Author(s):  
Zhihong Wu ◽  
Yu Wang ◽  
Wenjing Han ◽  
Kun Yang ◽  
Erhan Hai ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Hair Follicle ◽  
Regulation Mechanism ◽  
Follicle Development ◽  
Cashmere Goat ◽  
Expression Levels ◽  
Fetal Fibroblasts ◽  
Cashmere Goats ◽  
Polymerase Chain ◽  
Hair Follicle Development

Abstract. This study is focused on the detection of ectodysplasin A (EDA) and ectodysplasin A receptor (EDAR) mRNA expression levels and protein positions in seven stages of cashmere goat fetus development (45, 55, 65, 75 95, 115, and 135 d), with the main goal of investigating the effect of EDA and EDAR on genes related to hair follicle development. Quantitative real-time polymerase chain reaction (RT-qPCR) was used to measure EDA and EDAR expression levels in seven stages of cashmere goat fetus development. Immunohistochemistry (IHC) was used to locate EDA and EDAR in the critical stage of fetal hair follicle development (45–135 d). EDA and EDAR expression in fetal fibroblasts and epithelial cells was interfered with by short hairpin RNA (sh-RNA). The results indicated that EDA and EDAR were both expressed in the skin tissue in the seven cashmere goat embryo stages. Moreover, EDA and EDAR play an important role in the formation of embryonic placode (Pc). After interfering with EDA and EDAR, the expression of BMP2, BMP4, noggin, β-catenin, TGF-β2, Wnt-10b, and NOTCH1 in fibroblasts and epithelial cells changed significantly. This study provides a theoretical and experimental basis for further studying the molecular regulation mechanism of hair follicle development.

Hoxc13 Expression Pattern in Cashmere Goat Skin During Hair Follicle Development

2009 ◽  
Vol 8 (4) ◽  
pp. 491-496 ◽  
Author(s):  
Jiang-hong WU ◽  
Wen-guang ZHANG ◽  
Jin-quan LI ◽  
Jun YIN ◽  
Yan-jun ZHANG
Keyword(s):  
Hair Follicle ◽  
Expression Pattern ◽  
Follicle Development ◽  
Cashmere Goat ◽  
Goat Skin ◽  
Hair Follicle Development

Cyclic expression of Lhx2 is involved in secondary hair follicle development in cashmere goat

2014 ◽  
Vol 16 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Rongqing Geng ◽  
Lanping Wang ◽  
Xiaolong Wang ◽  
Yulin Chen
Keyword(s):  
Hair Follicle ◽  
Follicle Development ◽  
Cashmere Goat ◽  
Hair Follicle Development ◽  
Cyclic Expression

The Nude Mouse Skin Phenotype: The Role of Foxn1 in Hair Follicle Development and Cycling

2001 ◽  
Vol 71 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Lars Mecklenburg ◽  
Motonobu Nakamura ◽  
John P. Sundberg ◽  
Ralf Paus
Keyword(s):  
Hair Follicle ◽  
Nude Mouse ◽  
Mouse Skin ◽  
Follicle Development ◽  
Hair Follicle Development

scholarly journals Factors Mediating the Interactions Between Epidermal and Dermal Cells in Skin Grafts that Might Be Important for Hair Follicle Development

1995 ◽  
Vol 104 (5) ◽  
pp. 21-22 ◽  
Author(s):  
Tonja Kartasova ◽  
Aline B. Scandurro ◽  
Mitchell F. Denning ◽  
Stuart H. Yuspa ◽  
Ulrike Lichti ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Follicle Development ◽  
Skin Grafts ◽  
Hair Follicle Development ◽  
Dermal Cells
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