MicroRNA-7 inhibits melatonin synthesis by acting as a linking molecule between leptin and norepinephrine signaling pathways in pig pineal gland

2019 ◽  
Vol 66 (3) ◽  
pp. e12552 ◽  
Author(s):  
Jingtao Qiu ◽  
Jinglin Zhang ◽  
Yewen Zhou ◽  
Xin Li ◽  
Hongjiao Li ◽  
...  
Keyword(s):  
Pineal Gland ◽  
Signaling Pathways ◽  
Melatonin Synthesis

Monosodium glutamate administration early in life alters pineal melatonin nocturnal profile in adulthood

2021 ◽  
Vol 4 (1) ◽  
pp. 99-114
Author(s):  
Janaína B Garcia ◽  
Fernanda G Do Amaral ◽  
Daniela C Buonfiglio ◽  
Rafaela FA Vendrame ◽  
Patrícia L Alves ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Pineal Gland ◽  
Serum Insulin ◽  
Monosodium Glutamate ◽  
Female Rats ◽  
Pineal Melatonin ◽  
Melatonin Synthesis ◽  
Male And Female Rats ◽  
Melatonin Production

The pineal gland synthesizes melatonin exclusively at night, which gives melatonin the characteristic of a temporal synchronizer of the physiological systems. Melatonin is a regulator of insulin activities centrally and also peripherally and its synthesis is reduced in diabetes.  Since monosodium glutamate (MSG) is often used to induce the type 2 diabetic and metabolic syndrome in animal models, the purpose of this work is to evaluate the potential effects of MSG given to neonates on the pineal melatonin synthesis in different aged male and female rats. Wistar rats were subcutaneously injected with MSG (4mg/g/day) or saline solution (0.9%) from the second to eighth post-natal day. The circadian profiles both melatonin levels and AANAT activity were monitored at different ages. Body weight, naso-anal length, adipose tissues weight, GTT, ITT and serum insulin levels were also evaluated. Typical obesity with the neonatal MSG treatment was observed, indicated by a great increase in adipose depots without a concurrent increase in body weight. MSG treatment did not cause hyperglycemia or glucose intolerance, but induced insulin resistance. An increase of melatonin synthesis at ZT 15 with phase advance was observed in in some animals. The AANAT activity was positively parallel to the melatonin circadian profile. It seems that MSG causes hypothalamic obesity which may increase AANAT activity and melatonin production in pineal gland. These effects were not temporally correlated with insulin resistance and hyperinsulinemia indicating the hypothalamic lesions, particularly in arcuate nucleus induced by MSG in early age, as the principal cause of the increase in melatonin production.

scholarly journals Rumen-Protected 5-Hydroxytryptophan Improves Sheep Melatonin Synthesis in the Pineal Gland and Intestinal Tract

2019 ◽  
Vol 25 ◽  
pp. 3605-3616 ◽  
Author(s):  
Fang Zhao ◽  
Chen Ma ◽  
Guodong Zhao ◽  
Gen Wang ◽  
Xiaobin Li ◽  
...  
Keyword(s):  
Pineal Gland ◽  
Intestinal Tract ◽  
Melatonin Synthesis

Avian Melatonin Synthesis: Photic and Circadian Regulation of Serotonin N-Acetyltransferase mRNA in the Chicken Pineal Gland and Retina

2002 ◽  
Vol 68 (1) ◽  
pp. 213-224 ◽  
Author(s):  
Marianne Bernard ◽  
P. Michael Iuvone ◽  
Vincent M. Cassone ◽  
Patrick H. Roseboom ◽  
Steven L. Coon ◽  
...  
Keyword(s):  
Pineal Gland ◽  
Circadian Regulation ◽  
Melatonin Synthesis

Quantification of Daily Melatonin Synthesis in the Hamster Pineal Gland*

Endocrinology ◽  
1980 ◽  
Vol 106 (1) ◽  
pp. 231-236 ◽  
Author(s):  
MARK D. ROLLAG ◽  
ELIZABETH S. PANKE ◽  
WANTANEE TRAKULRUNGSI ◽  
CHATCHAI TRAKULRUNGSI ◽  
RUSSEL J. REITER
Keyword(s):  
Pineal Gland ◽  
Melatonin Synthesis
Sign in / Sign up

Export Citation Format

Share Document