Melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via PPARγ/FUNDC1/mitophagy pathways

2017 ◽  
Vol 63 (4) ◽  
pp. e12438 ◽  
Author(s):  
Hao Zhou ◽  
Dandan Li ◽  
Pingjun Zhu ◽  
Shunying Hu ◽  
Nan Hu ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Platelet Activation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cardiac Ischemia ◽  
And Function

scholarly journals Acid sensing ion channel 1a is a key mediator of cardiac ischemia-reperfusion injury

2019 ◽  
Author(s):  
Meredith A. Redd ◽  
Sarah E. Scheuer ◽  
Natalie J. Saez ◽  
Ling Gao ◽  
Mark Hicks ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Ion Channel ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Genetic Locus ◽  
Cardiac Ischemia ◽  
Myocardial Ischemia Reperfusion Injury ◽  
Myocardial Ischemia Reperfusion ◽  
And Function

AbstractThe proton-gated acid-sensing ion channel 1a (ASIC1a) is implicated in the injury response to cerebral ischemia but little is known about its role in cardiac ischemia. We provide genetic evidence that ASIC1a is involved in myocardial ischemia-reperfusion injury (IRI) and show that pharmacological inhibition of ASIC1a yields robust cardioprotection in rodent and human models of cardiac ischemia, resulting in improved post-IRI cardiac viability and function. Consistent with a key role for ASIC1a in cardiac ischemia, we show that polymorphisms in the ASIC1 genetic locus are strongly associated with myocardial infarction. Collectively, our data provide compelling evidence that ASIC1a is a key target for cardioprotective drugs to reduce the burden of disease associated with myocardial ischemia.

scholarly journals 406-1 Hypoxia regulatable Aav-2 vector protects against cardiac ischemia/reperfusion injury

2004 ◽  
Vol 43 (5) ◽  
pp. A533
Author(s):  
Alok S Pachori ◽  
Luis G Melo ◽  
Lunan Zhang ◽  
Richard E Pratt ◽  
Victor J Dzau
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cardiac Ischemia

scholarly journals Nanoparticle-Mediated Dual Delivery of an Antioxidant and a Peptide against the L-Type Ca2+ Channel Enables Simultaneous Reduction of Cardiac Ischemia-Reperfusion Injury

ACS Nano ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. 279-289 ◽  
Author(s):  
Naviin Hardy ◽  
Helena M. Viola ◽  
Victoria P. A. Johnstone ◽  
Tristan D. Clemons ◽  
Henrietta Cserne Szappanos ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cardiac Ischemia ◽  
Simultaneous Reduction

scholarly journals The Effect of High Dose Melatonin on Cardiac Ischemia-reperfusion Injury

2008 ◽  
Vol 49 (5) ◽  
pp. 735 ◽  
Author(s):  
Hakan Ceyran ◽  
Figen Narin ◽  
Nazmi Narin ◽  
Hülya Akgün ◽  
A. Bahar Ceyran ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cardiac Ischemia ◽  
High Dose

Multiple Treatment Approach to Limit Cardiac Ischemia-Reperfusion Injury

2005 ◽  
Vol 80 (4) ◽  
pp. 1408-1416 ◽  
Author(s):  
James E. Davies ◽  
Stanley B. Digerness ◽  
Cheryl R. Killingsworth ◽  
Corinne Zaragoza ◽  
Charles R. Katholi ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Treatment Approach ◽  
Ischemia Reperfusion ◽  
Cardiac Ischemia ◽  
Multiple Treatment
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