Melatonin improves mitochondrial function in inguinal white adipose tissue of Zücker diabetic fatty rats

2014 ◽  
Vol 57 (1) ◽  
pp. 103-109 ◽  
Author(s):  
Aroa Jimenéz-Aranda ◽  
Gumersindo Fernández-Vázquez ◽  
María Mohammad A-Serrano ◽  
Russel J. Reiter ◽  
Ahmad Agil
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Mitochondrial Function ◽  
Zucker Diabetic Fatty Rats

Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats

2013 ◽  
Vol 55 (4) ◽  
pp. 416-423 ◽  
Author(s):  
Aroa Jiménez-Aranda ◽  
Gumersindo Fernández-Vázquez ◽  
Daniel Campos ◽  
Mohamed Tassi ◽  
Lourdes Velasco-Perez ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Zucker Diabetic Fatty Rats

Sex differences in the effect of high-fat diet feeding on rat white adipose tissue mitochondrial function and insulin sensitivity

Metabolism ◽  
2012 ◽  
Vol 61 (8) ◽  
pp. 1108-1117 ◽  
Author(s):  
Emilia Amengual-Cladera ◽  
Isabel Lladó ◽  
Magdalena Gianotti ◽  
Ana M. Proenza
Keyword(s):  
Sex Differences ◽  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
White Adipose Tissue ◽  
Mitochondrial Function ◽  
High Fat Diet ◽  
High Fat

Mitochondrial function/dysfunction in white adipose tissue

2014 ◽  
Vol 99 (9) ◽  
pp. 1168-1178 ◽  
Author(s):  
Sihem Boudina ◽  
Timothy E. Graham
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Mitochondrial Function

Ameliorating effects of lifelong physical activity on healthy aging and mitochondrial function in human white adipose tissue

2021 ◽  
Author(s):  
Anders Gudiksen ◽  
Albina Qoqaj ◽  
Stine Ringholm ◽  
Jørgen Wojtaszewski ◽  
Peter Plomgaard ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Exercise Training ◽  
White Adipose Tissue ◽  
Mitochondrial Function ◽  
Mitochondrial Respiration ◽  
Healthy Aging ◽  
Venous Blood ◽  
Oxidative Capacity ◽  
Low Grade ◽  
Lifelong Exercise

Abstract Growing old is patently among the most prominent risk factors for lifestyle related diseases and deterioration in physical performance. Aging in particular affects mitochondrial homeostasis and maintaining a well-functioning mitochondrial pool is imperative in order to avoid age-associated metabolic decline. White adipose tissue (WAT) is a key organ in energy balance and impaired mitochondrial function in adipocytes has been associated with increased low-grade inflammation, altered metabolism, excessive ROS production and an accelerated aging phenotype. Exercise training improves mitochondrial health but whether lifelong exercise training can sufficiently maintain WAT mitochondrial function is currently unknown. Therefore, to dissect the role and dose-dependence of lifelong exercise training on aging WAT metabolic parameters and mitochondrial function, young and older untrained, as well as moderately and highly exercise trained older male subjects were recruited and abdominal subcutaneous (s)WAT biopsies and venous blood samples were obtained to measure mitochondrial function and key metabolic factors in WAT and plasma. Mitochondrial intrinsic respiratory capacity was lower in sWAT from older than in young subjects. In spite of this, maximal mitochondrial respiration per wet weight, markers of oxidative capacity, and mitophagic capacity were increased in sWAT from lifelong highly exercise trained than all other groups. Furthermore, ROS emission was generally lower in sWAT from lifelong highly exercise trained than older untrained subjects. Taken together, aging reduces intrinsic mitochondrial respiration in human sWAT, but lifelong high volume exercise training increases oxidative capacity by increasing mitochondrial volume likely contributing to healthy aging.

Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats

Amino Acids ◽  
2020 ◽  
Vol 52 (10) ◽  
pp. 1413-1423
Author(s):  
Rebecca M. Simmons ◽  
Sorin M. McKnight ◽  
Ashley K. Edwards ◽  
Guoyao Wu ◽  
Michael C. Satterfield
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Zucker Diabetic Fatty Rats

Sexual-Dimorphism in Exercise-Induced Beiging and Altered Mitochondrial Function in Inguinal White Adipose Tissue (iWAT) from the Mouse

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 758-P
Author(s):  
PASQUALE NIGRO ◽  
ROELAND MIDDELBEEK ◽  
CHRISTIANO R. ALVES ◽  
BRENT G. ALBERTSON ◽  
LESLIE A. ROWLAND ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Sexual Dimorphism ◽  
White Adipose Tissue ◽  
Mitochondrial Function ◽  
Exercise Induced

scholarly journals High-fat diet feeding induces a depot-dependent response on the pro-inflammatory state and mitochondrial function of gonadal white adipose tissue

2012 ◽  
Vol 109 (3) ◽  
pp. 413-424 ◽  
Author(s):  
E. Amengual-Cladera ◽  
I. Lladó ◽  
A. M. Proenza ◽  
M. Gianotti
Keyword(s):  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Mitochondrial Dysfunction ◽  
White Adipose Tissue ◽  
Mitochondrial Function ◽  
High Fat Diet ◽  
Serum Insulin ◽  
High Fat ◽  
Inflammatory State ◽  
Sensitivity Profile

Obesity has been related to a chronic pro-inflammatory state affecting white adipose tissue (WAT), which has a great impact on carbohydrate, lipid and energy metabolism. In turn, the dysregulation of adipokine secretion derived from the accumulation of excess lipids in adipocytes further contributes to the development of insulin resistance and can be associated with mitochondrial dysfunction. The aim of the present study was to determine whether sexual dimorphism found in the systemic insulin sensitivity profile is related to sex differences in a high-fat diet (HFD) response of gonadal WAT at mitochondrial function and inflammatory profile levels. Wistar rats (10 weeks old) of both sexes were fed a control pelleted diet (3 % (w/w) fat;n8 for each sex) or a HFD (24 % (w/w) fat;n8 for each sex). Serum insulin sensitivity markers, mRNA expression levels of inflammatory factors and the protein content of insulin and adiponectin signalling pathways were analysed, as well as the levels of the main markers of mitochondrial biogenesis, antioxidant defence and oxidative damage. In the present study, the periovarian depot exhibits a greater expandability capacity, along with a lower hypoxic and pro-inflammatory state, without signs of mitochondrial dysfunction or changes in its dynamics. In contrast, epididymal fat has a much more pronounced pro-inflammatory, hypoxic and insulin-resistant profile accompanied by changes in mitochondrial dynamics, probably associated with HFD-induced mitochondrial dysfunction. Thus, this explains the worse serum insulin sensitivity profile of male rats.

Sign in / Sign up

Export Citation Format

Share Document