The relationship between omega‐3 fatty acids and blood pressure

2018 ◽  
Vol 10 (2) ◽  
pp. 161-168
Author(s):  
Christy Abraham ◽  
Robert C. Speth
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
The Relationship

Abstract P120: Omega-3 Fatty Acid Supplementation in Middle-Aged Adults Reduces Cardiometabolic Risk in Men but not Women

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Claire Newlon ◽  
Matthew Muldoon ◽  
Susan Sereika ◽  
Dora Kuan
Keyword(s):  
Blood Pressure ◽  
Gender Differences ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Cardiometabolic Risk ◽  
Acid Metabolism ◽  
Hdl Cholesterol ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Middle Aged Adults

Background: Greater consumption of omega-3 fatty acids has been associated with lower cardiovascular disease risk. Randomized controlled trials indicate direct, albeit small, beneficial effects of omega-3 fatty acids on plasma triglycerides and blood pressure, yet few studies have tested their impact on insulin resistance and the clustered risk factors comprising the metabolic syndrome. Hypothesis: Short-term supplementation with marine omega-3 polyunsaturated fatty acids, EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) will improve aggregated cardiometabolic risk (CMR) in healthy middle-aged adults Methods: We conducted a double-blind, placebo-controlled, parallel group clinical trial. Subjects were 30-54 year-old adults free of atherosclerotic disease and diabetes whose intake of EPA and DHA totaled <300 mg/day. Each was randomly assigned to daily fish oil supplements (2g/day containing 1000 mg EPA and 400mg DHA) or matching soybean oil placebo for 18 weeks. Aggregate CMR at baseline and post-intervention was calculated as the standardized sum of standardized distributions of blood pressure, BMI, and fasting serum triglycerides, glucose, and HDL (reverse scored). Missing data due to dropouts (n=17) and outliers (1-6 per variable) were replaced by multivariate imputation. Outcome analyses were conducted with linear regressions of all randomized subjects based on intention-to-treat. Results: Participants were 272 healthy adult (57% (154 out of 272) women; 17% (47 out of 272) minority; mean age 42) Pittsburgh-area residents. At baseline, demographics, health parameters, physical activity and EPA and DHA consumption did not differ significantly between treatment groups. No overall treatment effect was found, whereas gender moderated the effects of treatment on CMR risk (gender, p=.001 and gender*treatment interaction term p=.011). In gender-specific analyses, supplementation lowered CMR risk relative to placebo in men(p=.036, effect size=.629, standard error (SE) =.282) but not women (p=.168, effect size .261, SE=.222). Of the individual CMR variables, only HDL-cholesterol in men revealed a significant improvement (p=.012). In men receiving placebo, HDL-cholesterol fell by 1.1 mg/dl, whereas in those receiving fish oil, HDL rose by 1.7 mg/dl. As has been noted in other samples, compared to women men had greater CMR and lower HDL-cholesterol. Conclusions: Increased intake of n-3 fatty acids over 4 months reduced CMR in healthy, mid-life men but not women. This finding may be due to poorer baseline CMR and HDL characteristic of men, or to gender differences in fatty acid metabolism. Further study of gender differences in cardiometabolic risk and fatty acid metabolism may lead to gender-tailored preventive interventions.

scholarly journals The intake assessment of diverse dietary patterns on childhood hypertension: alleviating the blood pressure and lipidemic factors with low-sodium seafood rich in omega-3 fatty acids

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Anahita Izadi ◽  
Leila Khedmat ◽  
Reza Tavakolizadeh ◽  
Sayed Yousef Mojtahedi
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Dietary Diversity ◽  
Density Lipoprotein ◽  
Second Phase ◽  
Inverse Association ◽  
Cumulative Number ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Childhood Hypertension

Abstract Background Childhood hypertension (CH) is related to the dietary intake and diversity of children. The study aimed to assess the critical role of dietary diversity, and seafood long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) in reducing CH among the Iranian community. Methods A cross-sectional two-phase study with 7–12-year-old Iranian students was designed. In the initial phase, the socio-demographic characteristics, and blood pressure status (normal, pre-hypertension, and hypertension) based on systolic (SBP) and diastolic (DBP) blood pressure data were assessed. The 24-h dietary recall questionnaire was used to generate the dietary diversity score (DDS, count of consumed food groups) and dietary variety score (DVS, the cumulative number of daily consumed food items). In the second phase, the association between CH reduction and changes in serum 25-hydroxyvitamin D (25OHD), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides (TG) levels of schoolchildren intervened by a seafood diet rich in omega-3 fatty acids were assessed using the regression analyses. Results The pre-hypertension and hypertension prevalence rates were 7.8 and 9.15%, respectively. CH was significantly associated with age, gender, and DDS. A significant inverse association was found between the high intake of seafood and CH (P = 0.032). The gas-chromatography analysis showed the high presence of α-linolenic (ALA, 6.72%), eicosapentaenoic (EPA, 7.62%), docosapentaenoic (DPA, 5.88%), and docosahexaenoic (DHA, 18.52%) acids in the seafood-based diet (p <  0.05). The low blood pressure levels with regular consumption of this healthy-functional diet were significantly associated with a reduction in BMI, LDL, TC, and TG, and a remarkable increase in 25OHD and HDL levels. The multiple linear regression showed that the SBP was highly associated with the TC (p <  0.001; β = 0.464). Conclusions The age and DDS were efficient predictors for the different CH status. A regular seafood-rich dietary pattern due to the high LC n-3 PUFAs contents could significantly reduce the obesity-related cardiovascular risk factors.

scholarly journals Omega-3 fatty acids and blood pressure

2012 ◽  
Vol 107 (S2) ◽  
pp. S195-S200 ◽  
Author(s):  
Jorge Cabo ◽  
Rodrigo Alonso ◽  
Pedro Mata
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Mild Hypertension ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Beneficial Effects ◽  
Metabolic Functions ◽  
Blue Fish ◽  
High Doses

Epidemiological and clinical studies suggest that consumption of omega (ω-3) polyunsaturated fatty acids (PUFA) contributes to the reduction of cardiovascular mortality through different mechanisms including modulation of cellular metabolic functions, gene expression and beneficial effects on lipid profile or blood pressure. The aim of the study is to review the effects of ω-3 PUFA supplemented as fish oil or blue fish in blood pressure. The analysis of different studies suggests that high doses ω-3 PUFA ( ≥  3 g/day) produces a small but significant decrease in blood pressure, especially systolic blood pressure, in older and hypertensive subjects; however, the evidence is not consistent among different studies. ω-3 polyunsaturated fatty acids consumption might have a place in the control of patients with mild hypertension before starting drug treatment and of those who prefer changes of lifestyles like diet.

scholarly journals Reply to Harris et al.: Differential impacts of omega-3 fatty acids and their derivatives on blood pressure

2013 ◽  
Vol 110 (25) ◽  
pp. E2260-E2260 ◽  
Author(s):  
T. Hoshi ◽  
B. Wissuwa ◽  
Y. Tian ◽  
N. Tajima ◽  
R. Xu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3

The effects of omega-3 fatty acids on blood pressure and serum lipids in men at increased risk of cardiovascular disease

1993 ◽  
Vol 11 (5) ◽  
pp. S318???S319 ◽  
Author(s):  
Lawrence J. Beilin ◽  
Trevor A. Mori ◽  
Robert Vandongen ◽  
Jenny Morris ◽  
Valerie Burke ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Fatty Acids ◽  
Serum Lipids ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Increased Risk

scholarly journals Omega-3 Fatty Acids and Cholesterol Have a Main Role in Antidepression Diet of Iranian Traditional Medicine

2016 ◽  
Vol 22 (2) ◽  
pp. 205-209
Author(s):  
Mohammad Mahdi Ahmadian-Attari ◽  
Ahmad Ali Noorbala ◽  
Alireza Khoshdel ◽  
Mohammad Kamalinejad ◽  
Arsia Taghva
Keyword(s):  
Fatty Acids ◽  
Traditional Medicine ◽  
Main Role ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Major Health ◽  
Nutritional Elements ◽  
Iranian Traditional Medicine ◽  
Main Components ◽  
The Relationship

Depression is one of the major health problems of our world. Recent studies have revealed the relationship between diet and depression. In Iranian traditional medicine, there is a therapeutic diet that is recommended in melancholic diseases like depression. One of the main components of this diet is meat. Meats are divided into 2 groups: recommended and abstinent. The aim of this study was to clarify the logic of this diet through comparing nutritional elements of the 2 groups with each other. For this purpose, prominent books on Iranian traditional medicine were searched for abstinent and recommended meats traditionally prescribed for depressed patients. The results of each group were compared with the other by using Mann-Whitney Test (SPSS version 16). The results showed that recommended meats contain higher amounts of polyunsaturated fatty acids ( P = .01) especially omega-3 ( P = .03). Both groups contain high amounts of cholesterol. Iranian traditional medicine recommends consumption of meats that contains cholesterol with omega-3 fatty acids in depression.

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