scholarly journals Metformin inhibits extracellular matrix accumulation, inflammation and proliferation of mesangial cells in diabetic nephropathy by regulating H19/miR‐143‐3p/TGF‐β1 axis

2020 ◽  
Vol 72 (8) ◽  
pp. 1101-1109 ◽  
Author(s):  
Jiang Xu ◽  
Ping Xiang ◽  
Linqing Liu ◽  
Jianran Sun ◽  
Shandong Ye
Keyword(s):  
Extracellular Matrix ◽  
Diabetic Nephropathy ◽  
Mesangial Cells ◽  
Matrix Accumulation ◽  
Tgf Β1

scholarly journals CCN3 suppresses TGF-β1-induced extracellular matrix accumulation in human mesangial cells in vitro

2017 ◽  
Vol 39 (2) ◽  
pp. 222-229 ◽  
Author(s):  
Hai-fei Liu ◽  
Hong Liu ◽  
Lin-li Lv ◽  
Kun-ling Ma ◽  
Yi Wen ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Mesangial Cells ◽  
Human Mesangial Cells ◽  
Matrix Accumulation ◽  
Tgf Β1

scholarly journals Ergosterol Ameliorates Diabetic Nephropathy by Attenuating Mesangial Cell Proliferation and Extracellular Matrix Deposition via the TGF-β1/Smad2 Signaling Pathway

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 483 ◽  
Author(s):  
Zhonghua Dong ◽  
Yueyue Sun ◽  
Guangwei Wei ◽  
Siying Li ◽  
Zhongxi Zhao
Keyword(s):  
Extracellular Matrix ◽  
Cell Proliferation ◽  
Diabetic Nephropathy ◽  
Signaling Pathway ◽  
Mesangial Cell ◽  
Mesangial Cells ◽  
Diabetic Mice ◽  
Mesangial Cell Proliferation ◽  
Tgf Β1

(1) Background: Diabetic nephropathy, a microvascular complication of diabetes, is one of the principal causes of end-stage renal disease worldwide. The aim of this study was to explore the therapeutic effects of ergosterol on diabetic nephropathy. (2) Methods: Streptozotocin (STZ)-induced C57BL/6 diabetic mice were treated with ergosterol (10, 20, 40 mg/kg/day) for 8 weeks by oral gavage. The in vitro study employed rat mesangial cells exposed to 30 mM glucose for 48 h in the presence of 10 or 20 μM ergosterol. (3) Results: Ergosterol treatment improved body weights, ameliorated the majority of biochemical and renal functional parameters and histopathological changes, and reduced extracellular matrix (ECM) deposition in diabetic mice. In vitro, ergosterol suppressed proliferation, reduced the levels of ECM proteins, and increased the expression of matrix metalloproteinase-2 and -9 in high glucose-induced mesangial cells; Furthermore, ergosterol markedly improved transforming growth factor-β1 (TGF-β1) expression, enhanced phosphorylation levels of drosophila mothers against decapentaplegic 2 (Smad2), and regulated the downstream factors in vivo and in vitro. (4) Conclusions: Ergosterol alleviated mesangial cell proliferation and the subsequent ECM deposition by regulating the TGF-β1/Smad2 signaling pathway.

scholarly journals Fractalkine and its receptor mediate extracellular matrix accumulation in diabetic nephropathy in mice

Diabetologia ◽  
2013 ◽  
Vol 56 (7) ◽  
pp. 1661-1669 ◽  
Author(s):  
K. H. Song ◽  
J. Park ◽  
J. H. Park ◽  
R. Natarajan ◽  
H. Ha
Keyword(s):  
Extracellular Matrix ◽  
Diabetic Nephropathy ◽  
Matrix Accumulation

scholarly journals Leptospiral Outer Membrane Protein Induces Extracellular Matrix Accumulation through a TGF-β1/Smad-Dependent Pathway

2006 ◽  
Vol 17 (10) ◽  
pp. 2792-2798 ◽  
Author(s):  
Ya-Chung Tian ◽  
Yung-Chang Chen ◽  
Cheng-Chieh Hung ◽  
Chiz-Tzung Chang ◽  
Mai-Szu Wu ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Membrane Protein ◽  
Outer Membrane ◽  
Outer Membrane Protein ◽  
Matrix Accumulation ◽  
Dependent Pathway ◽  
Tgf Β1
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