scholarly journals Self‐assembled liposome from core‐sheath chitosan‐based fibres for buccal delivery of carvedilol: formulation, characterization and in vitro and ex vivo buccal absorption

2019 ◽  
Vol 72 (3) ◽  
pp. 343-355
Author(s):  
Jianting Chen ◽  
Hao Pan ◽  
Hongliang Duan ◽  
Wenbin Deng ◽  
Fei Zhang ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Buccal Delivery ◽  
Buccal Absorption ◽  
Self Assembled

Novel Self-assembled, Gel-core Hyaluosomes for Non-invasive Management of Osteoarthritis: In-vitro Optimization, Ex-vivo and In-vivo Permeation

2015 ◽  
Vol 32 (9) ◽  
pp. 2901-2911 ◽  
Author(s):  
Wessam M. El-Refaie ◽  
Yosra S. R. Elnaggar ◽  
Magda A. El-Massik ◽  
Ossama Y. Abdallah
Keyword(s):  
Ex Vivo ◽  
Non Invasive ◽  
Self Assembled ◽  
Invasive Management

scholarly journals In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 398 ◽  
Author(s):  
Eleni Kontogiannidou ◽  
Martina Ferrari ◽  
Asteria-Danai Deligianni ◽  
Nikolaos Bouropoulos ◽  
Dimitrios A. Andreadis ◽  
...  
Keyword(s):  
Binary Systems ◽  
Ex Vivo ◽  
Rank Order ◽  
In Vitro Release ◽  
Order Effect ◽  
Buccal Delivery ◽  
Scanning Calorimetry ◽  
Cell Layers ◽  
Mucoadhesive Tablets

In the current study, the development of mucoadhesive tablets for buccal delivery of a non-steroidal anti-inflammatory drug was investigated. Binary complexes with piroxicam and cyclodextrins (β-cyclodextrin (β-CD), methylated-β-cyclodextrin (Me-β-CD), and hydroxypropyl-β-cyclodextrin (HP-β-CD)) were prepared by the co-evaporation method. All formulations were characterized by means of differential scanning calorimetry, infrared spectroscopy and powder X-ray diffractometry. Mucoadhesive tablets of binary systems were formulated by direct compression using chitosan as mucoadhesive polymer. The in vitro release profiles of tablets were conducted in simulated saliva and, the drug permeation studies, across porcine buccal mucosa. The results suggest that the rank order effect of cyclodextrins for the drug release was Me-β-CD > HP-β-CD > β-CD, whereas the ex vivo studies showed that the tablets containing chitosan significantly increased the transport of the drug compared to their free complexes. Finally, histological assessment revealed loss of the superficial cell layers, which might be attributed to the presence of cyclodextrins.

In vitro, ex vivo and in vivo examination of buccal absorption of metoprolol with varying pH in TR146 cell culture, porcine buccal mucosa and Göttingen minipigs

2013 ◽  
Vol 49 (2) ◽  
pp. 117-124 ◽  
Author(s):  
René Holm ◽  
Emil Meng-Lund ◽  
Morten B. Andersen ◽  
Mads L. Jespersen ◽  
Jens-Jacob Karlsson ◽  
...  
Keyword(s):  
Cell Culture ◽  
Buccal Mucosa ◽  
Ex Vivo ◽  
Buccal Absorption

Formulation Development And In Vitro-Ex Vivo Assessment Of Simvastatin Niosomal Buccal Films

2021 ◽  
Vol 15 ◽  
Author(s):  
Sudhakar Beeravelli ◽  
Vyasamurthy Akondi ◽  
Madhavi Nimmathota
Keyword(s):  
Buccal Cavity ◽  
Ex Vivo ◽  
Plain Film ◽  
Solvent Casting ◽  
Buccal Delivery ◽  
Formulation Development ◽  
Casting Technique ◽  
In Vitro Permeation ◽  
Buccal Films

Aim: Aim of the present study is to develop and characterize simvastatin niosomal film for effective buccal delivery. Methods: Simvastatin niosomes were developed by film hydration technique followed by high-pressure homogenization using chiller at 5°C. The simvastatin niosomes were characterized for various physicochemical parameters and simvastatin plain and niosomal films were prepared using PEO as the base by solvent casting technique. Results: From the simvastatin niosomes suspension, the percentage assay was found in the range of 96 to 103%, particles size was found in the range of 112nm to 308nm, the zeta potential was found in the range of -9 to -25.8mV, the %EE was found in the range of 28% to 91% and the in vitro permeation was found in the range of 43.41% to 98% respectively. The niosomal film shown superior results as compared to simvastatin plain film. The FTIR and DSC confirm the compatibility among the existed excipients. Conclusion: Niosomes alter the physicochemical properties of simvastatin by buccal route. The prolonged permeation (96.12% up to 24hrs) of simvastatin was observed from niosomes film across the porcine buccal cavity, due to the presence of CPE in the composition, which would be useful for effective buccal delivery.

In Vitro and Ex Vivo Evaluation of Novel Curcumin-Loaded Excipient for Buccal Delivery

2016 ◽  
Vol 18 (6) ◽  
pp. 2102-2109 ◽  
Author(s):  
Flavia Laffleur ◽  
Franziska Schmelzle ◽  
Ariane Ganner ◽  
Stefan Vanicek
Keyword(s):  
Ex Vivo ◽  
Buccal Delivery

Effects of the Tibetan herbal preparation PADMA 28 on blood lipids and lipid oxidisability in subjects with mild hypercholesterolaemia

VASA ◽  
2005 ◽  
Vol 34 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Brunner-La Rocca ◽  
Schindler ◽  
Schlumpf ◽  
Saller ◽  
Suter
Keyword(s):  
Endothelial Dysfunction ◽  
Blood Lipids ◽  
Ex Vivo ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Tibetan Medicine ◽  
Double Blind ◽  
Intraarterial Infusion ◽  
Padma 28

Background: Previous studies showed an anti-atherosclerotic effect of PADMA 28, an herbal formula based on Tibetan medicine. As the mechanisms of action are not fully understood, we investigated whether PADMA 28 may lower blood lipids and lipid oxidisability, and affect early endothelial dysfunction. Patients and methods: Sixty otherwise healthy subjects with total cholesterol ≥5.2 mmol/l and < 8.0 mmol/l were randomly assigned to placebo or PADMA 28, 3 x 2 capsules daily, for 4 weeks (double-blind). Blood lipids (total, LDL-, and HDL-cholesterol, triglycerides, Apo-lipoprotein A1 and B) and ex vivo lipid oxidisability were measured before and after treatment. In a subset of 24 subjects, endothelial function was assessed using venous occlusion plethysmography with intraarterial infusion of acetylcholine. Isolated LDL and plasma both untreated and pre-treated with PADMA 28 extract were oxidised by the radical generator AAPH. Conjugated diene formation was measured at 245 nm. Results: Blood lipids did not change during the study in both groups. In contrast to previous reports in mild hypercholesterolaemia, no endothelial dysfunction was seen and, consequently, was not influenced by therapy. Ex vivo blood lipid oxidisability was significantly reduced with PADMA 28 (area under curve: 5.29 ± 1.62 to 4.99 ± 1.46, p = 0.01), and remained unchanged in the placebo group (5.33 ± 1.88 to 5.18 ± 1.78, p > 0.1). This effect persisted one week after cessation of medication. In vitro experiments confirmed the prevention of lipid peroxidation in the presence of PADMA 28 extracts. Persistent protection was also seen for LDL isolated from PADMA 28-pretreated blood after being subjected to rigorous purification. Conclusions: This study suggests that the inhibition of blood lipid oxidisability by PADMA 28 may play a role in its anti-atherosclerotic effect.

The Role of Polyphenols in the Modulation of Plasma Non-Enzymatic Antioxidant Capacity (NEAC)

2012 ◽  
Vol 82 (3) ◽  
pp. 228-232 ◽  
Author(s):  
Mauro Serafini ◽  
Giuseppa Morabito
Keyword(s):  
Antioxidant Capacity ◽  
Dietary Intervention ◽  
Ex Vivo ◽  
The Body ◽  
Dietary Polyphenols ◽  
Enzymatic Antioxidant ◽  
Endogenous Antioxidant

Dietary polyphenols have been shown to scavenge free radicals, modulating cellular redox transcription factors in different in vitro and ex vivo models. Dietary intervention studies have shown that consumption of plant foods modulates plasma Non-Enzymatic Antioxidant Capacity (NEAC), a biomarker of the endogenous antioxidant network, in human subjects. However, the identification of the molecules responsible for this effect are yet to be obtained and evidences of an antioxidant in vivo action of polyphenols are conflicting. There is a clear discrepancy between polyphenols (PP) concentration in body fluids and the extent of increase of plasma NEAC. The low degree of absorption and the extensive metabolism of PP within the body have raised questions about their contribution to the endogenous antioxidant network. This work will discuss the role of polyphenols from galenic preparation, food extracts, and selected dietary sources as modulators of plasma NEAC in humans.

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