scholarly journals Current and novel anti-inflammatory drug targets for inhibition of cytokines and leucocyte recruitment in rheumatic diseases

2017 ◽  
Vol 70 (1) ◽  
pp. 18-26 ◽  
Author(s):  
Doreen E. Szollosi ◽  
Mohammed K. Manzoor ◽  
Andrea Aquilato ◽  
Patricia Jackson ◽  
Ola M. Ghoneim ◽  
...  
Keyword(s):  
Rheumatic Diseases ◽  
Drug Targets ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Leucocyte Recruitment

FRI0009 Il4-10 synerkine: a novel anti-inflammatory drug to inhibit immunopathology in rheumatic diseases

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A371.2-A371 ◽  
Author(s):  
S. A. Hartgring ◽  
C. Steens-Louws ◽  
M. de Smet ◽  
E. Hack ◽  
J. A. Van Roon
Keyword(s):  
Rheumatic Diseases ◽  
Inflammatory Drug ◽  
Anti Inflammatory

scholarly journals Capsule Endoscopy for Obscure Gastrointestinal Bleeding in Patients with Comorbid Rheumatic Diseases

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Neal Shahidi ◽  
George Ou ◽  
Jessica Tong ◽  
Ricky Kwok ◽  
Cherry Galorport ◽  
...  
Keyword(s):  
Gastrointestinal Bleeding ◽  
Rheumatic Diseases ◽  
Capsule Endoscopy ◽  
Vascular Lesions ◽  
Obscure Gastrointestinal Bleeding ◽  
Oral Steroid ◽  
Positive Finding ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Mass Lesions

Background and Aim. We evaluated the association between patients with rheumatic diseases (RD) suffering from obscure gastrointestinal bleeding (OGIB) and positive capsule endoscopy (CE) findings. Methods. All CE procedures performed on patients with RD and OGIB were assessed from a large database at St. Paul’s Hospital (Vancouver, BC, Canada) between December 2001 and April 2011. A positive finding on CE was defined as any pathology, including ulcers/erosions, vascular lesions, and mass lesions, perceived to be the source of bleeding. Results. Of the 1133 CEs performed, 41 (4%) complete CEs were for OGIB in patients with RD. Of these, 54% presented with overt bleeding. Mean age was 66 years. Positive findings were seen in 61% of patients. Ulcerations/erosions (36%) and vascular lesions (36%) were the most common findings. Significant differences between the RD versus non-RD populations included: inpatient status, nonsteroidal anti-inflammatory drug (NSAIDs) use, oral steroid use, and mean Charlson index score (all P≤0.008). Similar nonsignificant trends were seen between positive and negative CEs among the RD population. Conclusions. The correlation between RD and positive CE findings is likely influenced by ongoing anti-inflammatory drug use, poorer health status, and a predisposition for angiodysplastic lesions.

scholarly journals IMMUNE THROMBOCYTOPENIA

2016 ◽  
Vol 23 (05) ◽  
pp. 630-633
Author(s):  
Gulali Aktas ◽  
Rabia Altinordu ◽  
Zuhal Mercan ◽  
Haluk Savli
Keyword(s):  
Rheumatic Diseases ◽  
Immune Thrombocytopenia ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Immune thrombocytopenia (ITP) is an idiopathic disorder which could betriggered by various factors including; drugs, rheumatic diseases and malignancies. We aimedto present a 66 year old woman diagnosed with ITP whose history was relevant for influenzavaccine and non-steroidal anti-inflammatory drug (diclofenac) use. She responded well tostandard ITP therapy. In conclusion, medications should be elaborately questioned in patientswith thrombocytopenia, especially, when a diagnosis of ITP was considered.

10 reasons, why to use naproxen – in the light of new scientific reports

2021 ◽  
Vol 14 (4) ◽  
pp. 400-407
Author(s):  
Agnieszka Sękowska
Keyword(s):  
Rheumatic Diseases ◽  
Musculoskeletal System ◽  
Inflammatory Drug ◽  
Reversible Inhibition ◽  
Pain Syndromes ◽  
Wide Range ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Characteristic Features ◽  
Cox 1

Naproxen is a non-steroidal anti-inflammatory drug with a wide range of use, used in patients with various pain syndromes in the musculoskeletal system. It has anti-inflammatory, analgesic and antipyretic properties through non-selective and reversible inhibition of COX-1 and COX-2 isoforms. In Poland, it is registered in the treatment of rheumatic diseases and acute inflammations of the musculoskeletal system. Some naproxen preparations are also approved for the treatment of migraine and fever. The paper presents the characteristic features of the substance.

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