Assessing the influence of media composition and ionic strength on drug release from commercial immediate-release and enteric-coated aspirin tablets

2017 ◽  
Vol 69 (10) ◽  
pp. 1327-1340 ◽  
Author(s):  
Frank Karkossa ◽  
Sandra Klein
Keyword(s):  
Ionic Strength ◽  
Drug Release ◽  
Immediate Release ◽  
Media Composition ◽  
Enteric Coated Aspirin ◽  
Enteric Coated

scholarly journals Yosprala: Coordinated Delivery of a Proton Pump Inhibitor and Aspirin

2019 ◽  
Vol 36 (2) ◽  
pp. 78-83
Author(s):  
Courtney A. Ingram ◽  
Gracie Giang ◽  
Katie McCrory ◽  
Terri M. Wensel
Keyword(s):  
Clinical Trials ◽  
Secondary Prevention ◽  
Cardiovascular Events ◽  
English Language ◽  
Data Extraction ◽  
Immediate Release ◽  
Study Selection ◽  
Effective Option ◽  
Enteric Coated Aspirin ◽  
Enteric Coated

Objective: Review the pharmacology, pharmacokinetics, efficacy, and safety of Yosprala (aspirin and omeprazole). Data Sources: A literature search was conducted using PubMed with the terms “Yosprala,” “PA8140,” and “PA32540” from the initial year through May, 2019. Additional sources were gathered through bibliographies. Aralez Pharmaceuticals Inc was contacted for manufacturer information. Study Selection and Data Extraction: The sources were narrowed to studies done in English language between 1990 and 2019. All viable clinical trials for the use of Yosprala in the secondary prevention of cardiovascular events were included. Data Synthesis: Yosprala is a coordinated delivery system of immediate-release omeprazole 40 mg and enteric-coated aspirin (325 mg or 81 mg). In 2016, the Food and Drug Administration approved Yosprala for the secondary prevention of cardiovascular or cerebrovascular events (ie, stroke or myocardial infarction). While it is recommended that patients take low-dose aspirin for secondary prevention of these events, many patients cannot tolerate the gastrointestinal (GI) adverse effect profile of the drug. Phase 3 clinical trials have proven that Yosprala significantly lowers the occurrence of GI bleeds and ulcers versus aspirin alone (3.2% and 8.6%, respectively; P ≤ .001). The most common adverse effects include infection, diarrhea, and dyspepsia. Conclusion: Yosprala significantly reduces the occurrence of GI ulcers and seems to be a safe and effective option for the secondary prevention of cardiovascular events.

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