Permeation characteristics of hypericin across Caco‐2 monolayers in the presence of single flavonoids, defined flavonoid mixtures or Hypericum extract matrix

2017 ◽  
Vol 71 (1) ◽  
pp. 58-69 ◽  
Author(s):  
Sheela Verjee ◽  
Olaf Kelber ◽  
Christiane Kolb ◽  
Heba Abdel‐Aziz ◽  
Veronika Butterweck
Keyword(s):  
Hypericum Extract

Hypericum extract LI160 for depression with atypical features

2005 ◽  
Vol 38 (05) ◽  
Author(s):  
H Murck ◽  
H Spitznagel ◽  
M Ploch ◽  
U Schmidt
Keyword(s):  
Atypical Features ◽  
Hypericum Extract

Efficacy of a hypericum extract (STW3-VI) – A reanalysis

2017 ◽  
Vol 41 (S1) ◽  
pp. S535-S535
Author(s):  
J. Mueller ◽  
C. Kolb
Keyword(s):  
Data Structure ◽  
Positive Predictive Value ◽  
Predictive Value ◽  
Sleep Disturbances ◽  
Item Analysis ◽  
Significant Treatment ◽  
Single Item ◽  
Early Improvement ◽  
End Of Treatment ◽  
Hypericum Extract

IntroductionThe course of depression during therapy in studies is usually monitored by scales like HAMD. Also the course of single items of the HAMD during therapy might be of specific interest as some symptoms are of highly predictive value. Furthermore early improvement during antidepressive therapy is a new aspect which came into the focus.ObjectivesThe objectives of this study were to reanalyze clinical data regarding early improvement as well as specific symptoms or symptom cluster – like sleep disturbances.AimsThe aim of this study was to get deeper insight into the data structure of 2 RCTs (n = 398, 42 days treatment) comparing the efficacy of a hypericum extract (STW3-VI/900 mg once daily) to Placebo.MethodsData structure was evaluated by comparing the total scores of the HAMD-17 to a single item analysis and by calculating the factorial structure of the end of treatment data. The treatment potential was evaluated by calculating a positive predictive value from day 7 to the end of treatment. ANCOVA, factor analysis and regression methods were used.ResultsThe single item analyses were widely comparable to the highly significant treatment differences of the total scores as it were the calculated subscales. The positive predictive value of the treatment was about 75%.ConclusionsThe results underline the elsewhere proven treatment efficacy of STW3-VI regarding several new subscale aspects.Disclosure of interestCOI: The authors are employees of Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany.

Effects of Hypericum Extract (LI 160) in Biochemical Models of Antidepressant Activity

1997 ◽  
Vol 30 (S 2) ◽  
pp. 102-107 ◽  
Author(s):  
W. Müller ◽  
M. Rolli ◽  
C. Schäfer ◽  
U. Hafner
Keyword(s):  
Antidepressant Activity ◽  
Hypericum Extract

Neuroendocrine Effects of Hypericum Extract WS 5570 in 12 Healthy Male Volunteers

2001 ◽  
Vol 34 (Suppl1) ◽  
pp. 127-133 ◽  
Author(s):  
C. Schüle ◽  
T. Baghai ◽  
A. Ferrera ◽  
G. Laakmann
Keyword(s):  
Healthy Male ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Hypericum Extract
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