Development and validation of a stability indicating isocratic HPLC method for gemcitabine with application to drug release from poly lactic-co-glycolic acid nanoparticles and enzymatic degradation studies

2015 ◽  
Vol 67 (11) ◽  
pp. 1528-1536 ◽  
Author(s):  
Guanyu Chen ◽  
Darren Svirskis ◽  
Jingyuan Wen
Keyword(s):  
Drug Release ◽  
Enzymatic Degradation ◽  
Glycolic Acid ◽  
Hplc Method ◽  
Stability Indicating ◽  
Isocratic Hplc ◽  
Degradation Studies ◽  
Development And Validation

scholarly journals A REVIEW ON DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPLC METHODS FOR ANALYSIS OF ACIDIC DRUGS

2019 ◽  
pp. 22-33
Author(s):  
DEVYANI M. RODE ◽  
NUTAN N. RAO
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Biological Samples ◽  
High Performance ◽  
Hplc Method ◽  
Pharmaceutical Drugs ◽  
Stability Indicating ◽  
Acidic Drugs ◽  
Degradation Studies ◽  
Development And Validation

High-performance liquid chromatography is one of the fastest, safest and precise technology used for determination and separation of pharmaceutical drugs, impurities and biological samples. High-performance liquid chromatography is versatile and it takes less time for quantification of drugs as compared to old liquid chromatography techniques. This article reviews stability indicating HPLC method developed and validated for acidic drugs and their degradation studies.

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