scholarly journals One-step production of darunavir solid dispersion nanoparticles coated with enteric polymers using electrospraying

2015 ◽  
Vol 68 (5) ◽  
pp. 625-633 ◽  
Author(s):  
Duong Nhat Nguyen ◽  
Ljiljana Palangetic ◽  
Christian Clasen ◽  
Guy Van den Mooter
Keyword(s):  
Solid Dispersion ◽  
Enteric Polymers ◽  
One Step

scholarly journals Solubility Enhancement of Budesonide and Statistical Optimization of Coating Variables for Targeted Drug Delivery

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Himanshu Bhatt ◽  
Bhargavi Naik ◽  
Abhay Dharamsi
Keyword(s):  
Drug Release ◽  
Solid Dispersion ◽  
Statistical Design ◽  
Aqueous Solubility ◽  
Stability Study ◽  
Design Variables ◽  
Accelerated Stability ◽  
Eudragit S100 ◽  
Enteric Polymers

The purpose of the research was to present Budesonide (BUD) as a novel formulation showing improved aqueous solubility, which may decrease variability in Cmax⁡ and Tmax⁡ found in inflammatory bowel disease (IBD) patients, and drug targeting to colon. To improve aqueous solubility, solid dispersion (SD) of the BUD with poloxamer 188 was prepared by melting method. Physical characterization of solid dispersion was performed. The SD was used to prepare tablet equivalent to 9 mg of BUD. The tablet was coated with enteric polymers Eudragit S100 and Eudragit L100 to target colon. The ratio of polymers and percentage coating was optimized using statistical design. Variables studied in design were ratio of enteric polymers and the effect of percentage coating on in vitro drug release. Dissolution at different pH showed that drug release in colon could be modified by optimizing the ratio of polymers and percentage coating. The dissolution data showed that the percentage coating and ratio of polymers are very important to get lag time and optimum formulation. The optimized batch from statistical design was kept under accelerated condition for three months. After accelerated stability study, there was no significant change in the drug release.

scholarly journals Characterization of Amorphous Solid Dispersion of Pharmaceutical Compound with pH-Dependent Solubility Prepared by Continuous-Spray Granulator

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 159 ◽  
Author(s):  
Ryoma Tanaka ◽  
Yusuke Hattori ◽  
Yukun Horie ◽  
Hitoshi Kamada ◽  
Takuya Nagato ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Process Development ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion ◽  
Pharmaceutical Ingredients ◽  
Solid Dosage ◽  
Manufacturing Operations ◽  
One Step ◽  
Granulation Technology

A continuous-spray granulator (CTS-SGR) is a one-step granulation technology capable of using solutions or suspensions. The present research objectives were, (1) to reduce the manufacturing operations for solid dosage formulations, (2) to make amorphous solid dispersion (ASD) granules without pre-preparation of amorphous solids of active pharmaceutical ingredients (API), and (3) to characterize the obtained SGR granules by comprehensive pharmaceutical analysis. Rebamipide (RBM), a biopharmaceutical classification system class IV drug, that has low solubility or permeability in the stomach, was selected as a model compound. Five kind of granules with different concentrations of polyvinylpyrrolidone/vinyl acetate copolymer (PVP-VA) were prepared using a one-step SGR process. All of the SGR granules could be produced in amorphous or ASD form and their thermodynamic stability was very high because of high glass transition temperatures (>178 °C). They were unstable in 20 °C/75%RH; however, their stability was improved according to the proportion of polymer. The carboxy group of RBM was ionized in the granules and interactions appeared between RBM and PVP-VA, with the formation of an ASD confirmed and the solubility was enhanced compared with bulk RBM crystals. The SGR methodology has the possibility of contributing to process development in the pharmaceutical industry.

scholarly journals One-step mechanochemical preparation and prominent antitumor activity of SN-38 self-micelle solid dispersion

2019 ◽  
Vol Volume 14 ◽  
pp. 2115-2126 ◽  
Author(s):  
Xuanrong Sun ◽  
Dabu Zhu ◽  
Yue Cai ◽  
Guobang Shi ◽  
Mengshi Gao ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Solid Dispersion ◽  
One Step

Enhanced dissolution of silymarin/polyvinylpyrrolidone solid dispersion pellets prepared by a one-step fluid-bed coating technique

2008 ◽  
Vol 182 (1) ◽  
pp. 72-80 ◽  
Author(s):  
Ningyun Sun ◽  
Xiuli Wei ◽  
Baojian Wu ◽  
Jian Chen ◽  
Yi Lu ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Coating Technique ◽  
Enhanced Dissolution ◽  
Fluid Bed ◽  
One Step ◽  
Fluid Bed Coating

An Interactive Minicomputer Program for the Indexing and Simulation of Electron Diffraction Patterns

1976 ◽  
Vol 34 ◽  
pp. 542-543
Author(s):  
R.P. Goehner ◽  
W.T. Hatfield ◽  
Prakash Rao
Keyword(s):  
Electron Diffraction ◽  
Real Time ◽  
Pattern Analysis ◽  
Flow Diagram ◽  
Hard Copy ◽  
Time Analysis ◽  
Real Time Analysis ◽  
Transmission Electron ◽  
One Step ◽  
Diffraction Patterns

Computer programs are now available in various laboratories for the indexing and simulation of transmission electron diffraction patterns. Although these programs address themselves to the solution of various aspects of the indexing and simulation process, the ultimate goal is to perform real time diffraction pattern analysis directly off of the imaging screen of the transmission electron microscope. The program to be described in this paper represents one step prior to real time analysis. It involves the combination of two programs, described in an earlier paper(l), into a single program for use on an interactive basis with a minicomputer. In our case, the minicomputer is an INTERDATA 70 equipped with a Tektronix 4010-1 graphical display terminal and hard copy unit.A simplified flow diagram of the combined program, written in Fortran IV, is shown in Figure 1. It consists of two programs INDEX and TEDP which index and simulate electron diffraction patterns respectively. The user has the option of choosing either the indexing or simulating aspects of the combined program.

Nutrient-regulated gene expression in eukaryotes

2006 ◽  
Vol 73 ◽  
pp. 85-96 ◽  
Author(s):  
Richard J. Reece ◽  
Laila Beynon ◽  
Stacey Holden ◽  
Amanda D. Hughes ◽  
Karine Rébora ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Transcriptional Control ◽  
Direct Interaction ◽  
Signalling Pathways ◽  
A Cell ◽  
One Step ◽  
Higher Eukaryotes ◽  
Regulated Gene Expression

The recognition of changes in environmental conditions, and the ability to adapt to these changes, is essential for the viability of cells. There are numerous well characterized systems by which the presence or absence of an individual metabolite may be recognized by a cell. However, the recognition of a metabolite is just one step in a process that often results in changes in the expression of whole sets of genes required to respond to that metabolite. In higher eukaryotes, the signalling pathway between metabolite recognition and transcriptional control can be complex. Recent evidence from the relatively simple eukaryote yeast suggests that complex signalling pathways may be circumvented through the direct interaction between individual metabolites and regulators of RNA polymerase II-mediated transcription. Biochemical and structural analyses are beginning to unravel these elegant genetic control elements.

CAD: One Step Forward, One Step Back

2010 ◽  
Vol 43 (18) ◽  
pp. 16
Author(s):  
MATTHEW R.G. TAYLOR
Keyword(s):  
One Step

The absorption characteristics of bifendate solid dispersion in rat intestinal tissue

2009 ◽  
Vol 00 (00) ◽  
pp. 090810023429058-9
Author(s):  
Juan Cheng ◽  
Zheng Hong Wu ◽  
Qineng Neng Ping ◽  
Bogang Wang ◽  
Junjun Lu
Keyword(s):  
Solid Dispersion ◽  
Intestinal Tissue ◽  
Absorption Characteristics
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