Effect of composition in the development of carbamazepine hot-melt extruded solid dispersions by application of mixture experimental design

2013 ◽  
Vol 66 (2) ◽  
pp. 232-243 ◽  
Author(s):  
Jelena Djuris ◽  
Nikolakakis Ioannis ◽  
Svetlana Ibric ◽  
Zorica Djuric ◽  
Kyriakos Kachrimanis
Keyword(s):  
Experimental Design ◽  
Solid Dispersions ◽  
Mixture Experimental Design ◽  
Hot Melt

scholarly journals Slack-Variable Model in Mixture Experimental Design Applied to Wood Plastic Composite

2021 ◽  
Author(s):  
Javier Cruz-Salgado ◽  
Sergio Alonso Romero ◽  
Edgar Ruelas-Santoyo ◽  
Roxana Zaricell Bautista López ◽  
Sergio Álvarez-Rodríguez
Keyword(s):  
Experimental Design ◽  
Wood Plastic Composite ◽  
Variable Model ◽  
Plastic Composite ◽  
Slack Variable ◽  
Mixture Experimental Design

scholarly journals Influence of Particle Size and Drug Load on Amorphous Solid Dispersions Containing pH-Dependent Soluble Polymers and the Weak Base Ketoconazole

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Marius Monschke ◽  
Kevin Kayser ◽  
Karl G. Wagner
Keyword(s):  
Particle Size ◽  
Phase Separation ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
Drug Load ◽  
Soluble Polymers ◽  
Eudragit L100 ◽  
Ph Dependent ◽  
Hot Melt

AbstractAmong the great number of poorly soluble drugs in pharmaceutical development, most of them are weak bases. Typically, they readily dissolve in an acidic environment but are prone to precipitation at elevated pH. This was aimed to be counteracted by the preparation of amorphous solid dispersions (ASDs) using the pH-dependent soluble polymers methacrylic acid ethylacrylate copolymer (Eudragit L100–55) and hydroxypropylmethylcellulose acetate succinate (HPMCAS) via hot-melt extrusion. The hot-melt extruded ASDs were of amorphous nature and single phased with the presence of specific interactions between drug and polymer as revealed by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FT-IR). The ASDs were milled and classified into six particle size fractions. We investigated the influence of particle size, drug load, and polymer type on the dissolution performance. The best dissolution performance was achieved for the ASD made from Eudragit L100–55 at a drug load of 10%, whereby the dissolution rate was inversely proportional to the particle size. Within a pH-shift dissolution experiment (from pH 1 to pH 6.8), amorphous-amorphous phase separation occurred as a result of exposure to acidic medium which caused markedly reduced dissolution rates at subsequent higher pH values. Phase separation could be prevented by using enteric capsules (Vcaps Enteric®), which provided optimal dissolution profiles for the Eudragit L100–55 ASD at a drug load of 10%.

scholarly journals An investigation into the formations of the internal microstructures of solid dispersions prepared by hot melt extrusion

2020 ◽  
Vol 155 ◽  
pp. 147-161
Author(s):  
Fahad Alqahtani ◽  
Peter Belton ◽  
Bin Zhang ◽  
Mohammed Al-Sharabi ◽  
Steven Ross ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Hot Melt
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