Synthesis, characterization and in vitro extracellular and intracellular activity against Mycobacterium tuberculosis infection of new second-line antitubercular drug-palladium complexes

2013 ◽  
Vol 66 (1) ◽  
pp. 106-121 ◽  
Author(s):  
Stefano Giovagnoli ◽  
Maria Luisa Marenzoni ◽  
Morena Nocchetti ◽  
Claudio Santi ◽  
Paolo Blasi ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Palladium Complexes ◽  
Tuberculosis Infection ◽  
Second Line ◽  
Antitubercular Drug ◽  
Mycobacterium Tuberculosis Infection ◽  
Intracellular Activity

An in vitro model of the leukocyte interactions associated with granuloma formation in Mycobacterium tuberculosis infection

2007 ◽  
Vol 85 (2) ◽  
pp. 160-168 ◽  
Author(s):  
Kristin A Birkness ◽  
Jeannette Guarner ◽  
Suraj B Sable ◽  
Ralph A Tripp ◽  
Kathryn L Kellar ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
In Vitro Model ◽  
Granuloma Formation ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Vitro Model

scholarly journals Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases

2012 ◽  
Vol 45 (1) ◽  
pp. 134-137 ◽  
Author(s):  
Paulo Antas ◽  
Steven Holland ◽  
Timothy Sterling
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Lymphocytes ◽  
Ex Vivo ◽  
Receptor Expression ◽  
Interleukin 8 ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Purified Protein Derivative ◽  
Spontaneous Expression

Interleukin 8 (CXCL8) is an autocrine chemokine specific for the chemoattraction and activation of granulocytes, NKT cells and T lymphocytes. Patients with tuberculosis and latent Mycobacterium tuberculosis infection were assessed for the spontaneous expression of CXCR1 (CD128) and CXCR2 on lymphocytes and monocytes. Compared with ex vivo profiles, increased spontaneous CXCR2 expression and normal CXCR1 expression were found on lymphocytes in two out of 59 individuals. Monocytes showed normal ex vivo profiles for both receptors. After stimulation with purified protein derivative, the in vitro levels of CXCL8 were below the median levels of all patients with prior tuberculosis. Spontaneous CXCR2 modulation did not cause notable variation in the in vitro levels of CXCL8.

scholarly journals In vitro immunomodulation for enhancing T cell–based diagnosis of Mycobacterium tuberculosis infection

2015 ◽  
Vol 83 (1) ◽  
pp. 41-45
Author(s):  
Madeline Slater ◽  
Minh-Chi Tran ◽  
Lauren Platt ◽  
Lien T. Luu ◽  
Ha T. Phan ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection
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