Retinal vascular lesions

2017 ◽  
Vol 53 (1) ◽  
pp. 90-90
Keyword(s):  
Vascular Lesions ◽  
Retinal Vascular Lesions

scholarly journals Reduced Levels of Drp1 Protect against Development of Retinal Vascular Lesions in Diabetic Retinopathy

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1379
Author(s):  
Dongjoon Kim ◽  
Hiromi Sesaki ◽  
Sayon Roy
Keyword(s):  
Diabetic Retinopathy ◽  
Cell Loss ◽  
Vascular Lesions ◽  
Protective Effects ◽  
Diabetic Mice ◽  
Wild Type ◽  
Apoptotic Genes ◽  
Retinal Vascular Lesions ◽  
Acellular Capillaries ◽  
Pericyte Loss

High glucose (HG)-induced Drp1 overexpression contributes to mitochondrial dysfunction and promotes apoptosis in retinal endothelial cells. However, it is unknown whether inhibiting Drp1 overexpression protects against the development of retinal vascular cell loss in diabetes. To investigate whether reduced Drp1 level is protective against diabetes-induced retinal vascular lesions, four groups of mice: wild type (WT) control mice, streptozotocin (STZ)-induced diabetic mice, Drp1+/− mice, and STZ-induced diabetic Drp1+/− mice were examined after 16 weeks of diabetes. Western Blot analysis indicated a significant increase in Drp1 expression in the diabetic retinas compared to those of WT mice; retinas of diabetic Drp1+/− mice showed reduced Drp1 level compared to those of diabetic mice. A significant increase in the number of acellular capillaries (AC) and pericyte loss (PL) was observed in the retinas of diabetic mice compared to those of the WT control mice. Importantly, a significant decrease in the number of AC and PL was observed in retinas of diabetic Drp1+/− mice compared to those of diabetic mice concomitant with increased expression of pro-apoptotic genes, Bax, cleaved PARP, and increased cleaved caspase-3 activity. Preventing diabetes-induced Drp1 overexpression may have protective effects against the development of vascular lesions, characteristic of diabetic retinopathy.

Retinal vascular lesions

2017 ◽  
Vol 53 (1) ◽  
pp. 89-89 ◽  
Author(s):  
Koushik Tripathy ◽  
Yog Raj Sharma
Keyword(s):  
Vascular Lesions ◽  
Retinal Vascular Lesions

scholarly journals Opa1 Deficiency Promotes Development of Retinal Vascular Lesions in Diabetic Retinopathy

2021 ◽  
Vol 22 (11) ◽  
pp. 5928
Author(s):  
Dongjoon Kim ◽  
Marcela Votruba ◽  
Sayon Roy
Keyword(s):  
Diabetic Retinopathy ◽  
Caspase 3 ◽  
Vascular Lesions ◽  
Apoptotic Cells ◽  
Diabetic Mice ◽  
Cytochrome C Release ◽  
Retinal Vascular Lesions ◽  
Acellular Capillaries ◽  
Pericyte Loss ◽  
Retinal Capillaries

This study investigates whether reduced optic atrophy 1 (Opa1) level promotes apoptosis and retinal vascular lesions associated with diabetic retinopathy (DR). Four groups of mice: wild type (WT) control mice, streptozotocin (STZ)-induced diabetic mice, Opa1+/− mice, and diabetic Opa1+/− mice were used in this study. 16 weeks after diabetes onset, retinas were assessed for Opa1 and Bax levels by Western blot analysis, and retinal networks were examined for acellular capillaries (AC) and pericyte loss (PL). Apoptotic cells were detected in retinal capillaries using TUNEL assay, and caspase-3 activity was assessed using fluorometric analysis. Opa1 expression was significantly downregulated in retinas of diabetic and Opa1+/− mice compared with those of WT mice. Inducing diabetes further decreased Opa1 expression in retinas of Opa1+/− mice. Increased cytochrome c release concomitant with increased level of pro-apoptotic Bax and elevated caspase-3 activity were observed in retinas of diabetic and Opa1+/− mice; the number of TUNEL-positive cells and AC/PL was also significantly increased. An additional decrease in the Opa1 level in retinas of diabetic Opa1+/− mice exacerbated the development of apoptotic cells and AC/PL compared with those of diabetic mice. Diabetes-induced Opa1 downregulation contributes, at least in part, to the development of retinal vascular lesions characteristic of DR.

Association of reduced Connexin 43 expression with retinal vascular lesions in human diabetic retinopathy

2016 ◽  
Vol 146 ◽  
pp. 103-106 ◽  
Author(s):  
Thomas Tien ◽  
Tetsuya Muto ◽  
Joyce Zhang ◽  
Elliott H. Sohn ◽  
Robert F. Mullins ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Connexin 43 ◽  
Vascular Lesions ◽  
Retinal Vascular Lesions

scholarly journals Identification of Retinal Vascular Lesions Using Ultra-Widefield Angiography in Hereditary Hemorrhagic Telangiectasia Patients

2019 ◽  
Vol 3 (6) ◽  
pp. 510-515
Author(s):  
Sampat Sindhar ◽  
Bliss E. O’Bryhim ◽  
Jordan Licata ◽  
Jay F. Piccirillo ◽  
Rajendra S. Apte
Keyword(s):  
Hereditary Hemorrhagic Telangiectasia ◽  
Vascular Lesions ◽  
Retinal Vascular Lesions
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