Neonatal early‐onset sepsis calculator safety in an Australian tertiary perinatal centre

2022 ◽  
Author(s):  
Philip A Scott ◽  
Melissa Lai ◽  
Garry D T Inglis ◽  
Mark W Davies
Keyword(s):  
Early Onset ◽  
Early Onset Sepsis ◽  
Sepsis Calculator

Neonatal Early-Onset Sepsis Calculator and Antibiotic Therapy—Reply

2020 ◽  
Vol 174 (5) ◽  
pp. 508
Author(s):  
Niek B. Achten ◽  
Claus Klingenberg ◽  
Frans B. Plötz
Keyword(s):  
Antibiotic Therapy ◽  
Early Onset ◽  
Early Onset Sepsis ◽  
Sepsis Calculator

scholarly journals Early-Onset Sepsis Risk Calculator: A Review Of Its Effectiveness And Comparative Study With Our Evidence-Based Local Guidelines

2021 ◽  
Author(s):  
Gianluigi Laccetta ◽  
Massimiliano Ciantelli ◽  
Cristina Tuoni ◽  
Emilio Sigali ◽  
Mario Miccoli ◽  
...  
Keyword(s):  
Gestational Age ◽  
Early Onset ◽  
Clinical Signs ◽  
Risk Calculator ◽  
Live Births ◽  
Early Onset Sepsis ◽  
Number Of Patients ◽  
Sepsis Risk ◽  
Empirical Antibiotics ◽  
Sepsis Calculator

Abstract Background According to most early-onset sepsis management guidelines, approximately 10% of the total neonatal population are exposed to antibiotics in the first postnatal days with subsequent increase of neonatal and pediatric comorbidities. Early-onset sepsis risk calculator has been developed with the purpose of avoiding antibiotic overtreatment among neonates ≥ 34 weeks’ gestational age: a review of literature demonstrates its effectiveness in reducing antibiotic overtreatment, laboratory testing, painful procedures and NICU admission; however, some missed cases of culture-positive early-onset sepsis have also been described. Methods All neonates with birth weight ≤ 1500 g, 34–36 weeks’ gestational age neonates with suspected intraamniotic infection and neonates with three clinical signs of early-onset sepsis or two signs and one risk factor for early-onset sepsis receive empirical antibiotics. Neonates ≥ 34 weeks’ gestational age with risk factors for early-onset sepsis or with one clinical indicator of early-onset sepsis undergo serial measurements of C-reactive protein and procalcitonin in the first 48–72 hours of life; they receive empirical antibiotics in case of abnormalities at blood exams with one or more clinical signs of early-onset sepsis. We therefore compared the number of patients for which antibiotics were needed, based on early-onset sepsis calculator, and the number of patients we treated with antibiotics during the study period. Comparisons between the groups were performed using McNemar’s test and statistical significance was set at p < 0.05. Results During the study period (1st January 2018-31st December 2018) 32/265 (12.1%) neonates ≥ 34 weeks’ gestational age at risk for early-onset sepsis received antibiotics within the first 12 hours of life. According to early-onset sepsis calculator: 55/265 (20.7%) patients would have received antibiotics with early-onset sepsis incidence 2/1000 live births (p < 0.0001); 44/265 (16.6%) patients would have received antibiotics with early-onset sepsis incidence 0.1/1000 live births (p < 0.025). One patient with culture-negative early-onset sepsis would not have received antibiotics with an early-onset sepsis incidence of 0.1/1000 live births. Conclusion Our evidence-based protocol for treatment decision-making of neonatal early-onset sepsis entails a further decrease of antibiotic overtreatment compared to early-onset sepsis risk calculator. No negative consequences for patients were observed.

Implementation of the Neonatal Sepsis Calculator in Early-Onset Sepsis and Maternal Chorioamnionitis

2020 ◽  
Vol 20 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Gangaram Akangire ◽  
Elizabeth Simpson ◽  
Julie Weiner ◽  
Janelle Noel-MacDonnell ◽  
Joshua Petrikin ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Early Onset ◽  
Early Onset Sepsis ◽  
Sepsis Calculator

A comparison of Triple I classification with neonatal early-onset sepsis calculator recommendations in neonates born to mothers with clinical chorioamnionitis

2020 ◽  
Vol 40 (9) ◽  
pp. 1308-1314
Author(s):  
Cassandra Coleman ◽  
David L. Carola ◽  
Amy J. Sloane ◽  
Margaret A. Lafferty ◽  
Amanda Roman ◽  
...  
Keyword(s):  
Early Onset ◽  
Early Onset Sepsis ◽  
Sepsis Calculator
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