Multi‐incident analysis of reviews of serious adverse clinical events in children with serious bacterial infection and/or sepsis in Queensland, Australia between 2012 and 2017

2021 ◽  
Author(s):  
Mark G Coulthard ◽  
Jodie M Osborne ◽  
Kevin McCaffery ◽  
Sharon A McAuley ◽  
Julie A McEniery
Keyword(s):  
Bacterial Infection ◽  
Clinical Events ◽  
Incident Analysis

scholarly journals Serum Protein Changes in Malignant Diseases. I. The Acute Leukemias

Blood ◽  
1960 ◽  
Vol 16 (4) ◽  
pp. 1479-1490 ◽  
Author(s):  
JOHN L. FAHEY ◽  
DANE R. BOGGS
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Serum Albumin ◽  
Bacterial Infection ◽  
Serum Protein ◽  
Lymphoblastic Leukemia ◽  
Acute Leukemias ◽  
Clinical Events ◽  
Essentially Normal ◽  
Wide Range ◽  
Range Of Values

Abstract A study of the serum protein changes and clinical events in acute myeloblastic and acute lymphoblastic leukemia was undertaken as a part of investigations on the effects of malignancies in man. In order to appraise the effects of the leukemic processes, an evaluation of the effects of disease type, activity, complications and therapy was also undertaken. Over a five-year period, clinical appraisal and electrophoretic serum protein analyses were compared 171 times in 82 patients with acute lymphoblastic leukemia and 64 times in 28 patients with acute myeloblastic leukemia. Serum electrophoretic evaluation showed characteristic patterns in the two types of acute leukemia studied. Analyses conducted in the absence of fever, infection or liver disease typically revealed elevation of the gamma globulins in myeloblastic but not in lymphoblastic leukemia. Alpha-2 globulin elevation, however, was representative of active lymphoblastic leukemia. Serum albumin was significantly lowered, and the beta globulins component remained essentially normal in both myeloblastic and lymphoblastic leukemia. Alpha-1 and alpha-2 globulin values were notable for the wide range of values obtained. Hematologic remission in some patients with acute lymphoblastic leukemia was associated with a return of albumin and alpha globulin values toward normal, but the total experience indicated a general persistence during remission of the abnormalities seen in active diseases. Fever, in the absence of infection, was associated with elevation of the alpha-1 globulin component. Bacterial infection was associated with similar elevation of the alpha-1 globulin fraction and, in addition, a further fall in serum albumin levels. Marked depression of the gamma globulins was unusual. The mild decreases encountered in lymphoblastic leukemia could not be related to the frequency of bacterial infection. Administration of antimetabolites or adrenal corticosteroids could not be shown to produce any direct effect on the serum electrophoretic components.

Release, Aggregation and Lysis of Human Platelets by Antilymphocyte Globulin and Antiplatelet Serum

1976 ◽  
Vol 36 (02) ◽  
pp. 411-423 ◽  
Author(s):  
Nicholas Lekas ◽  
J. C Rosenberg
Keyword(s):  
Platelet Aggregation ◽  
Gamma Globulin ◽  
Human Platelets ◽  
Plasma Medium ◽  
Release Reaction ◽  
Clinical Events ◽  
Thrombotic Complications ◽  
Platelet Release ◽  
Free Media

SummaryHuman platelets labeled with 51Cr were used to determine the contribution made by platelet lysis to the platelet release reaction and platelet aggregation induced by rabbit antihuman platelet serum (APS) and equine antihuman thymocyte globulin (ATG). Platelets were tested in both plasma (PRP) and non-plasma containing media. Antibodies directed against platelets, either as APS or ATG, induced significant amounts of platelet release and aggregation, as well as some degree of lysis, in the absence of complement. The presence of complement increased platelet lysis and aggregation, but not the release reaction. Non-immune horse gamma globulin produced different responses depending upon whether platelets were investigated in PRP or non-plasma containing media. Aggregation was seen in the latter but not the former. These differences can be explained by the presence of plasma components which prevent non-specific immune complexes from causing platelet aggregation. Since platelets in vivo are always in a plasma medium, one must be wary of utilizing data from platelet studies in synthetic plasma-free media as the basis of explaining clinical events. These observations demonstrate at least two, and possibly three, different mechanisms whereby ATG could activate platelets causing thrombotic complications and thrombocytopenia, i.e., via 1) specific and, 2) non-specific non-lytic pathways and 3) a lytic pathway.

Herpetic Whitlow of the Hand in Infants

2020 ◽  
Author(s):  
Mohammad M. Al-Qattan ◽  
Nada G. AlQadri ◽  
Ghada AlHayaza
Keyword(s):  
Bacterial Infection ◽  
Case Reports ◽  
Case Series ◽  
Individual Case ◽  
Senior Author ◽  
Secondary Bacterial Infection ◽  
Clinical Appearance ◽  
History Of ◽  
Mode Of Transmission ◽  
Time Of Presentation

Abstract Introduction Herpetic whitlows in infants are rare. Previous authors only reported individual case reports. We present a case series of six infants. Materials and Methods This is a retrospective study of six cases of herpetic whitlows in infants seen by the senior author (MMA) over the past 23 years (1995–2017 inclusive). The following data were collected: age, sex, digit involved in the hand, mode of transmission, time of presentation to the author, clinical appearance, presence of secondary bacterial infection, presence of other lesions outside the hand, method of diagnosis, treatment, and outcome. Results All six infants initially presented with classic multiple vesicles of the digital pulp. In all cases, there was a history of active herpes labialis in the mother. Incision and drainage or deroofing of the vesicles (for diagnostic purposes) resulted in secondary bacterial infection. Conclusion The current report is the first series in the literature on herpetic whitlows in infants. We stress on the mode of transmission (from the mother) and establishing the diagnosis clinically. In these cases, no need for obtaining viral cultures or polymerase chain reaction; and no medications are required. Once the vesicles are disrupted, secondary bacterial infection is frequent and a combination of oral acyclovir and intravenous antibiotics will be required.

Usefulness of Procalcitonin in the Diagnosis of Early Neonatal Bacterial Infection

2014 ◽  
Vol 4 (2) ◽  
pp. 85 ◽  
Author(s):  
Jimyung Kim ◽  
Miyoung Jang ◽  
Sun Hoe Koo ◽  
Kye Chul Kwon
Keyword(s):  
Bacterial Infection

Therapeutic efficacy of Proteflazid, suppository among the patients with genitourinary viral-bacterial infection

2016 ◽  
pp. 162-166
Author(s):  
V.O. Benyuk ◽  
◽  
O.I. Grinevich ◽  
I.A. Usevich ◽  
I.S. Sikachova ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Therapeutic Efficacy
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