Prior administration of chocolate improves the palatability of bitter drugs: The Choc‐with‐Med study

2021 ◽  
Author(s):  
Shannon Truong ◽  
Edith Kai Yan Tang ◽  
R. Nazim Khan ◽  
Minh Ngoc Nguyen ◽  
Britta S. von Ungern Sternberg ◽  
...  
Keyword(s):  
Prior Administration

The Effect of Haematoporphyrin Derivative on the Uptake of 67Ga, 59Fe and 65Zn in Tumours

1978 ◽  
Vol 17 (06) ◽  
pp. 262-265
Author(s):  
A. Phillips Carol ◽  
D.M. Taylor
Keyword(s):  
Fold Increase ◽  
Haematoporphyrin Derivative ◽  
Tumour Bearing ◽  
Rats And Mice ◽  
Prior Administration

The effect of prior administration of haematoporphyrin derivative on the uptake in tumours of 67Ga, 59Fe and 65Zn has been studied in tumour-bearing rats and mice. An approximately two-fold increase in the uptake of 67Ga was observed in the August 15 rat tumour when the nuclide was administered 17 to 24 hr after haematoporphyrin. No increase in the uptake of 67Ga occurred in three mouse tumours. Haematoporphyrin administration did not affect the uptake of 65Zn and 59Fe in any of the tumour systems. It is concluded that the presence of haematoporphyrin does not markedly increase the ability of tumours to accummulate metallic radionuclides.

295 Feasibility Examination of Prior Administration of Cyclophosphamide in TC Combination

2012 ◽  
Vol 48 ◽  
pp. S128
Author(s):  
H. Abe ◽  
Y. Kawai ◽  
T. Mori ◽  
H. Cho ◽  
Y. Kubota ◽  
...  
Keyword(s):  
Prior Administration

scholarly journals Does prior administration of enoxaparin influence the effects of levobupivacaine on blood clotting? Assessment using the Thrombelastograph®

2001 ◽  
Vol 86 (6) ◽  
pp. 808-813 ◽  
Author(s):  
S.A. Leonard ◽  
A. Lydon ◽  
M. Walsh ◽  
C. Fleming ◽  
J. Boylan ◽  
...  
Keyword(s):  
Blood Clotting ◽  
Prior Administration

Capsaicin-activated bronchial- and alveolar-initiated pathways regulating tracheal ciliary beat frequency

1994 ◽  
Vol 77 (3) ◽  
pp. 1239-1245 ◽  
Author(s):  
M. Eljamal ◽  
L. B. Wong ◽  
D. B. Yeates
Keyword(s):  
Low Dose ◽  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Neural Stimulation ◽  
Short Exposure ◽  
Tracheal Lumen ◽  
Prolonged Stimulation ◽  
Prior Administration ◽  
Stimulation Of ◽  
Ciliary Beat

We questioned whether the prolonged stimulation of ciliary beat frequency (CBF) to a short exposure of low-dose capsaicin (Wong et al. J. Appl. Physiol. 68: 257–2580, 1990) could be due to the activation of indirect pathways involving neural reflexes initiated independently in the bronchi and alveoli. Tracheal CBF (CBFtr) was measured temporally in anesthetized groups of 10 dogs by means of heterodyne-mode correlation analysis laser light scattering. To elucidate the site of the afferent neural stimulation and the efferent mediators affecting the ciliated epithelium, capsaicin (3 nM) aerosol was delivered for 4 min, either predominantly to the bronchi or to the alveolar regions, with use of pulsed aerosol techniques. This resulted in 13 pg of bronchial (85%) and 10 pg of alveolar (96%) capsaicin deposited, which caused marked stimulation of CBFtr with maxima at 7 and 35 min, respectively. Prior administration of aerosolized indomethacin to the bronchi or aerosolized cromolyn to the alveoli inhibited the bronchial and alveolar responses, respectively. Prior administration of aerosolized hexamethonium to the tracheal lumen blocked the stimulatory CBFtr responses from both capsaicin challenges. Ipratropium or propranolol aerosols delivered to the tracheal lumen also inhibited these responses. It is proposed that these pathways comprise one set of sensitive mechanisms to ensure a prolonged stimulation of CBF to effect the removal of secretions and the irritant from the lungs.

Effect of electrical stimulation of the crossed olivocochlear bundle on temporary threshold shifts in auditory sensitivity. I. Dependence on electrical stimulation parameters

1988 ◽  
Vol 60 (2) ◽  
pp. 549-568 ◽  
Author(s):  
R. Rajan
Keyword(s):  
Electrical Stimulation ◽  
Compound Action Potential ◽  
Afferent Input ◽  
High Rate ◽  
Central Location ◽  
Olivocochlear Bundle ◽  
Sound Exposure ◽  
Entire Duration ◽  
Subsequent Exposure ◽  
Prior Administration

1. This study examines the effect on auditory desensitization of electrically stimulating the crossed olivocochlear bundle (COCB) at the floor of the fourth ventricle. Auditory desensitization was induced by a loud high-frequency pure tone exposure and measured as temporary threshold shifts (TTS) in the sensitivity of the compound action potential recorded from the cochlea. COCB stimulation simultaneous with the loud sound exposure reduced the TTS. This reduction was contingent on the COCB stimulus being presented as a continuous burst for the entire duration (1 min) of the exposure. 2. The reduction in TTS could be abolished by prior administration of strychnine. The action of strychnine on these TTS effects of continuous COCB stimulation paralleled its action on the classical COCB effects elicited by pulsed short COCB trains. If the action of strychnine on the classical COCB effects was allowed to reverse, then continuous COCB stimulation reduced TTS as effectively as before. 3. The most effective COCB stimulus was found to be one that was presented at a high rate of stimulation simultaneous with the exposure. The COCB effect on TTS was also found to be a tonic one; smaller but significant reductions in TTS could still be obtained with the exposure presented 5 min after COCB stimulation though not when the delay was 10 min. The tonic reductions in TTS appeared to occur without any persisting changes at the cochlea. Normal cochlear responses remeasured in the delay between the stimulus and exposure were not altered. 4. It was hypothesized that the persisting effect responsible for TTS reductions did not occur at the cochlea but at some central site facilitated by antidromic action potentials along the COCB fibers. Subsequent exposure to loud sounds would activate the central site primed by the prior COCB stimulus. This hypothesis was tested by stimulating the COCB alone as before, but then lesioning the fibers before presenting the exposure. Persistent cochlear effects of the COCB stimulus should have still resulted in a reduction in TTS. However, if the persistent effect was at a more central location, lesioning the fibers would allow afferent input to act at the facilitated central location but would not allow subsequent expression of COCB effects at the cochlea. In this case, no reductions in TTS could be expected--precisely the results that were obtained in these experiments. Thus the COCB system appeared to have a "memory" component facilitated by prior stimulation and activated by a subsequent exposure.

scholarly journals Oxalate Absorption is Blocked by Prior Administration of Calcium in Rats

2002 ◽  
Vol 93 (2) ◽  
pp. 296
Author(s):  
Rayhan Zubair Hossain ◽  
Makoto Morozumi ◽  
Kimio Sugaya ◽  
Tadashi Hatano ◽  
Yoshihide Ogawa
Keyword(s):  
Oxalate Absorption ◽  
Prior Administration

scholarly journals Injection ranitidine induced death

2020 ◽  
Vol 9 (10) ◽  
pp. 1607
Author(s):  
S. Anandhi ◽  
R. Mani
Keyword(s):  
Receptor Antagonist ◽  
World Wide ◽  
Rare Event ◽  
Clinical History ◽  
Histological Data ◽  
History Of ◽  
Prior Administration

Ranitidine is a histamine-2-receptor antagonist. It was a commonly used drug. It holds excellent safety record. Anaphylactic reactions to ranitidine is uncommonly encountered. Death due to ranitidine is extremely a rare event and very few cases are reported world-wide. Clinical history, Lab investigations and histological data of a 43-Years old woman with negative history of allergic events, who died suddenly after the intra-venous administration of 50mg of intravenous ranitidine which was prescribed as a routine pre medication prior hysterectomy is presented below. Though the incidence of anaphylactic reactions is less with ranitidine, precautions to be taken prior administration of the drug and when such an event is encountered it should be promptly managed.

Mivacurium Pharmacodynamics with and without Prior Administration of Succinylcholine

1994 ◽  
Vol 81 (SUPPLEMENT) ◽  
pp. A1060
Author(s):  
M. R. Belmont ◽  
C. A. Lien ◽  
A. Abalos ◽  
L. M. Eppich ◽  
J. J. Savarese
Keyword(s):  
Prior Administration
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