scholarly journals EXOME SEQUENCING IN CONGENITAL DEAFNESS: A POPULATION‐BASED COHORT STUDY

2020 ◽  
Vol 56 (S2) ◽  
pp. 6-7
Keyword(s):  
Cohort Study ◽  
Exome Sequencing ◽  
Population Based ◽  
Congenital Deafness

scholarly journals Exome sequencing in infants with congenital hearing impairment: a population-based cohort study

2019 ◽  
Vol 28 (5) ◽  
pp. 587-596 ◽  
Author(s):  
Lilian Downie ◽  
◽  
Jane Halliday ◽  
Rachel Burt ◽  
Sebastian Lunke ◽  
...  
Keyword(s):  
Cohort Study ◽  
Exome Sequencing ◽  
Hearing Impairment ◽  
Population Based ◽  
Congenital Hearing Impairment

scholarly journals A protocol for whole-exome sequencing in newborns with congenital deafness: a prospective population-based cohort

2017 ◽  
Vol 1 (1) ◽  
pp. e000119 ◽  
Author(s):  
Lilian Downie ◽  
Jane L Halliday ◽  
Rachel A Burt ◽  
Sebastian Lunke ◽  
Elly Lynch ◽  
...  
Keyword(s):  
Exome Sequencing ◽  
Whole Exome Sequencing ◽  
Population Based ◽  
Congenital Deafness ◽  
Whole Exome

Estimated GFR and Incidence of Major Surgery: A Population-Based Cohort Study

2020 ◽  
Author(s):  
Tyrone G. Harrison ◽  
Shannon M. Ruzycki ◽  
Matthew T. James ◽  
Paul E. Ronksley ◽  
Kelly B. Zarnke ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Major Surgery ◽  
Estimated Gfr

Epidemiology of pheochromocytoma and paraganglioma: population-based cohort study

2021 ◽  
Vol 184 (1) ◽  
pp. 19-28
Author(s):  
Alexander A Leung ◽  
Janice L Pasieka ◽  
Martin D Hyrcza ◽  
Danièle Pacaud ◽  
Yuan Dong ◽  
...  
Keyword(s):  
Cohort Study ◽  
Administrative Data ◽  
Laboratory Data ◽  
Population Based ◽  
Incidence Rates ◽  
Primary Objective ◽  
Administrative Databases ◽  
Secondary Objective ◽  
True Frequency ◽  
Clinical Records

Objective Despite the significant morbidity and mortality associated with pheochromocytoma and paraganglioma, little is known about their epidemiology. The primary objective was to determine the incidence of pheochromocytoma and paraganglioma in an ethnically diverse population. A secondary objective was to develop and validate algorithms for case detection using laboratory and administrative data. Design Population-based cohort study in Alberta, Canada from 2012 to 2019. Methods Patients with pheochromocytoma or paraganglioma were identified using linked administrative databases and clinical records. Annual incidence rates per 100 000 people were calculated and stratified according to age and sex. Algorithms to identify pheochromocytoma and paraganglioma, based on laboratory and administrative data, were evaluated. Results A total of 239 patients with pheochromocytoma or paraganglioma (collectively with 251 tumors) were identified from a population of 5 196 368 people over a period of 7 years. The overall incidence of pheochromocytoma or paraganglioma was 0.66 cases per 100 000 people per year. The frequency of pheochromocytoma and paraganglioma increased with age and was highest in individuals aged 60–79 years (8.85 and 14.68 cases per 100 000 people per year for males and females, respectively). An algorithm based on laboratory data (metanephrine >two-fold or normetanephrine >three-fold higher than the upper limit of normal) closely approximated the true frequency of pheochromocytoma and paraganglioma with an estimated incidence of 0.54 cases per 100 000 people per year. Conslusion The incidence of pheochromocytoma and paraganglioma in an unselected population of western Canada was unexpectedly higher than rates reported from other areas of the world.

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