scholarly journals THE EFFECT OF HUMAN AMNION EPITHELIAL CELLS IN BRAINS OF VENTILATED PRETERM LAMBS

2019 ◽  
Vol 55 (S1) ◽  
pp. 123-124
Keyword(s):  
Epithelial Cells ◽  
Human Amnion ◽  
Amnion Epithelial Cells

scholarly journals Interleukin 4 Production by Human Amnion Epithelial Cells and Regulation of its Activity by Glycosaminoglycan Binding1

1995 ◽  
Vol 52 (4) ◽  
pp. 839-847 ◽  
Author(s):  
Catherine A. Jones ◽  
Keryn A. Williams ◽  
John J. Finlay-Jones ◽  
Prue H. Hart
Keyword(s):  
Epithelial Cells ◽  
Interleukin 4 ◽  
Human Amnion ◽  
Amnion Epithelial Cells

scholarly journals Transplantation of Human Amnion Epithelial Cells Reduces Hepatic Fibrosis in Immunocompetent CCl4-Treated Mice

2010 ◽  
Vol 19 (9) ◽  
pp. 1157-1168 ◽  
Author(s):  
Ursula Manuelpillai ◽  
Jorge Tchongue ◽  
Dinushka Lourensz ◽  
Vijesh Vaghjiani ◽  
Chrishan S. Samuel ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Hepatic Fibrosis ◽  
Human Amnion ◽  
Amnion Epithelial Cells

scholarly journals Effect of Human Amnion Epithelial Cells on the Acute Inflammatory Response in Fetal Sheep

2017 ◽  
Vol 8 ◽  
Author(s):  
Alana Westover ◽  
Jacqueline M. Melville ◽  
Courtney McDonald ◽  
Rebecca Lim ◽  
Graham Jenkin ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Inflammatory Response ◽  
Acute Inflammatory Response ◽  
Fetal Sheep ◽  
Human Amnion ◽  
Amnion Epithelial Cells

Transplantation of Human Amnion Epithelial Cells Improves Endometrial Regeneration in Rat Model of Intrauterine Adhesions

2020 ◽  
Vol 29 (20) ◽  
pp. 1346-1362
Author(s):  
Xiaolan Ouyang ◽  
Shuang You ◽  
Yulin Zhang ◽  
Chanyu Zhang ◽  
Guanghui Zhang ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Rat Model ◽  
Intrauterine Adhesions ◽  
Human Amnion ◽  
Amnion Epithelial Cells ◽  
Endometrial Regeneration

Adhesion of human amnion epithelial cells to extracellular matrix

1984 ◽  
Vol 153 (2) ◽  
pp. 425-438 ◽  
Author(s):  
J.D. Aplin ◽  
S. Campbell ◽  
L.J. Foden
Keyword(s):  
Extracellular Matrix ◽  
Epithelial Cells ◽  
Human Amnion ◽  
Amnion Epithelial Cells

scholarly journals Human Amnion Epithelial Cells Produce Soluble Factors that Enhance Liver Repair by Reducing Fibrosis While Maintaining Regeneration in a Model of Chronic Liver Injury

2020 ◽  
Vol 29 ◽  
pp. 096368972095022
Author(s):  
Alexander Hodge ◽  
Neil Andrewartha ◽  
Dinushka Lourensz ◽  
Robyn Strauss ◽  
Jeanne Correia ◽  
...  
Keyword(s):  
Liver Injury ◽  
Epithelial Cells ◽  
Chronic Liver ◽  
Hepatocyte Proliferation ◽  
Chronic Liver Injury ◽  
Paracrine Factors ◽  
Soluble Factors ◽  
Human Amnion ◽  
Liver Repair ◽  
Amnion Epithelial Cells

Human amnion epithelial cells (hAECs) exert potent antifibrotic and anti-inflammatory effects when transplanted into preclinical models of tissue fibrosis. These effects are mediated in part via the secretion of soluble factors by hAECs which modulate signaling pathways and affect cell types involved in inflammation and fibrosis. Based on these reports, we hypothesized that these soluble factors may also support liver regeneration during chronic liver injury. To test this, we characterized the effect of both hAECs and hAEC-conditioned medium (CM) on liver repair in a mouse model of carbon tetrachloride (CCl4)-induced fibrosis. Liver repair was assessed by liver fibrosis, hepatocyte proliferation, and the liver progenitor cell (LPC) response. We found that the administration of hAECs or hAEC-CM reduced liver injury and fibrosis, sustained hepatocyte proliferation, and reduced LPC numbers during chronic liver injury. Additionally, we undertook in vitro studies to document both the cell–cell and paracrine-mediated effects of hAECs on LPCs by investigating the effects of co-culturing the LPCs and hAECs and hAEC-CM on LPCs. We found little change in LPCs co-cultured with hAECs. In contrast, hAEC-CM enhances LPC proliferation and differentiation. These findings suggest that paracrine factors secreted by hAECs enhance liver repair by reducing fibrosis while promoting regeneration during chronic liver injury.

scholarly journals Human amnion epithelial cells modulate the inflammatory response to ventilation in preterm lambs

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0173572 ◽  
Author(s):  
Jacqueline M. Melville ◽  
Courtney A. McDonald ◽  
Robert J. Bischof ◽  
Graeme R. Polglase ◽  
Rebecca Lim ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Inflammatory Response ◽  
Human Amnion ◽  
Amnion Epithelial Cells
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