scholarly journals Characterising the Maturation of T Cell Polarisation in Preterm and Term Infants and in the Neonatal Chronic Lung Disease Bronchopulmonary Dysplasia

2018 ◽  
Vol 54 ◽  
pp. 30-30
Keyword(s):  
T Cell ◽  
Lung Disease ◽  
Bronchopulmonary Dysplasia ◽  
Chronic Lung Disease ◽  
Term Infants ◽  
Neonatal Chronic Lung Disease

Neonatal Chronic Lung Disease in Extremely Immature Baboons

1999 ◽  
Vol 160 (4) ◽  
pp. 1333-1346 ◽  
Author(s):  
JACQUELINE J. COALSON ◽  
VICKI T. WINTER ◽  
THERESA SILER-KHODR ◽  
BRADLEY A. YODER
Keyword(s):  
Lung Disease ◽  
Chronic Lung Disease ◽  
Neonatal Chronic Lung Disease

Bronchopulmonary Dysplasia and Care Techniques

PEDIATRICS ◽  
1987 ◽  
Vol 80 (1) ◽  
pp. 121-122
Author(s):  
ALISTAIR G. S. PHILIP ◽  
DALE L. KESSLER
Keyword(s):  
Lung Disease ◽  
Bronchopulmonary Dysplasia ◽  
Study Design ◽  
Chronic Lung Disease ◽  
Oxygen Requirement ◽  
End Point ◽  
Definition Of

To the Editor.— Although the paper by Avery et al1 is both interesting and provocative, readers should be cautioned about the inherent limitations of data generated by a retrospective, multicentered study design. First, the definition of chronic lung disease leaves much to be desired. The diagnosis was "arbitrarily defined" as an oxygen requirement greater than room air at 28 days of age. Evaluation of the need for oxygen at 3 months is a much more clinically relevant end point, but the numbers in this category were too small to evaluate adequately.

Breath-to-breath variability of exhaled CO2 as a marker of lung dysmaturity in infancy

2017 ◽  
Vol 123 (6) ◽  
pp. 1563-1570 ◽  
Author(s):  
Sotirios Fouzas ◽  
Ilias Theodorakopoulos ◽  
Edgar Delgado-Eckert ◽  
Philipp Latzin ◽  
Urs Frey
Keyword(s):  
Lung Disease ◽  
Preterm Infants ◽  
Chronic Lung Disease ◽  
Tidal Breathing ◽  
Term Infants ◽  
Young Infants ◽  
Postmenstrual Age ◽  
Preterm Group ◽  
Preterm Born ◽  
The Relationship

The concept of diffusional screening implies that breath-to-breath variations in CO2 clearance, when related to the variability of breathing, may contain information on the quality and utilization of the available alveolar surface. We explored the validity of the above hypothesis in a cohort of young infants of comparable postmenstrual age but born at different stages of lung maturity, namely, in term-born infants ( n = 128), preterm-born infants without chronic lung disease of infancy (CLDI; n = 53), and preterm infants with moderate/severe CLDI ( n = 87). Exhaled CO2 volume (VE,CO2) and concentration (FE,CO2) were determined by volumetric capnography, whereas their variance was assessed by linear and nonlinear variability metrics. The relationship between relative breath-to-breath change of VE,CO2 (ΔVE,CO2) and the corresponding change of tidal volume (ΔVT) was also analyzed. Nonlinear FE,CO2 variability was lower in CLDI compared with term and non-CLDI preterm group ( P < 0.001 for both comparisons). In CLDI infants, most of the VE,CO2 variability was attributed to the variability of VT ( r2 = 0.749), whereas in term and healthy preterm infants this relationship was weaker ( r2 = 0.507 and 0.630, respectively). The ΔVE,CO2 − ΔVT slope was less steep in the CLDI group (1.06 ± 0.07) compared with non-CLDI preterm (1.16 ± 0.07; P < 0.001) and term infants (1.20 ± 0.10; P < 0.001), suggesting that the more dysmature the infant lung, the less efficiently it eliminates CO2 under tidal breathing conditions. We conclude that the temporal variation of CO2 clearance may be related to the degree of lung dysmaturity in early infancy. NEW & NOTEWORTHY Young infants exhibit appreciable breath-to-breath CO2 variability that can be quantified by nonlinear variability metrics and may reflect the degree of lung dysmaturity. In infants with moderate/severe chronic lung disease of infancy (CLDI), the variability of the exhaled CO2 is mainly driven by the variability of breathing, whereas in term-born and healthy preterm infants this relationship is less strong. The slope of the relative CO2-to-volume change is less steep in CLDI infants, suggesting that dysmature lungs are less efficient in eliminating CO2 under tidal breathing conditions.

Sign in / Sign up

Export Citation Format

Share Document