scholarly journals Small for gestational age (SGA) infants with prolonged hypoglycaemia and high glucose infusion rates - role of early diazoxide therapy

2017 ◽  
Vol 53 ◽  
pp. 16-17
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
High Glucose ◽  
Glucose Infusion

scholarly journals 151 Role of diazoxide therapy in small for gestational age infants with prolonged hyperinsulinemic hypoglycemia

2021 ◽  
Author(s):  
Sandra Jaya-Bodestyne ◽  
Victor Samuel Rajadurai ◽  
Mohanambal Arumugham ◽  
Mei Chien Chua ◽  
Fabian Yap ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Hyperinsulinemic Hypoglycemia

P-014. Role of sFlt-1/PlGF as a predictor of small for gestational age

2021 ◽  
Vol 25 ◽  
pp. e33
Author(s):  
Selina Chiu ◽  
Saira Dhanji ◽  
Muthukuda Jayawardena ◽  
Natasha Djedovic ◽  
Hiran Samarage
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age

scholarly journals 1614High Rates of Preterm Birth and Small for Gestational Age in a Cohort of HIV Infected Women in Canada: Role of Ritonavir Boosted Regimens?

2014 ◽  
Vol 1 (suppl_1) ◽  
pp. S430-S431
Author(s):  
Fatima Kakkar ◽  
Isabelle Boucoiran ◽  
Terry Lee ◽  
Joel Singer ◽  
Laura J. Sauve ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Gestational Age ◽  
Small For Gestational Age

scholarly journals Fetal sex modifies the effect of maternal macronutrient intake on the incidence of small-for-gestational-age births: a prospective observational cohort study

2018 ◽  
Vol 108 (4) ◽  
pp. 814-820 ◽  
Author(s):  
A Mukhopadhyay ◽  
T Thomas ◽  
R J Bosch ◽  
P Dwarkanath ◽  
A Thomas ◽  
...  
Keyword(s):  
Cohort Study ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Macronutrient Intake ◽  
Fetal Sex ◽  
Increased Risk ◽  
Observational Cohort

Abstract Background Maternal macronutrient intake is likely to play a pivotal role in fetoplacental growth. Male fetuses grow faster and their growth is more responsive to maternal size. Objective We assessed the role of fetal sex in modifying the effect of maternal macronutrient intake on the risk of small-for-gestational-age (SGA) birth. Design This was a prospective, observational cohort study of 2035 births from an urban South Asian Indian population. Maternal intakes of total energy and macronutrients were recorded by validated food-frequency questionnaires. The interaction of trimester 1 macronutrient intake with fetal sex was tested on the outcome of SGA births. Results The prevalence of SGA was 28%. Trimester 1 macronutrient composition was high in carbohydrate and low in fat (means ± SDs—carbohydrate: 64.6% ± 5.1%; protein: 11.5% ± 1.1%; and fat: 23.9% ± 4.4% of energy). Higher carbohydrate and lower fat consumption were each associated with an increased risk of SGA [adjusted OR (AOR) per 5% of energy (95% CI): carbohydrate: 1.15 (1.01, 1.32); fat: 0.83 (0.71, 0.97)] specifically among male births (males: n = 1047; females: n = 988). Dietary intake of >70% of energy from carbohydrate was also associated with increased risk (AOR: 1.67; 95% CI: 1.00, 2.78), whereas >25% of energy from fat intake was associated with decreased risk (AOR: 0.61; 95% CI: 0.41, 0.90) of SGA in male births. Conclusions Higher carbohydrate and lower fat intakes early in pregnancy were associated with increased risk of male SGA births. Therefore, we speculate that fetal sex acts as a modifier of the role of maternal periconceptional nutrition in optimal fetoplacental growth.

scholarly journals Growth in Small-for-Gestational-Age Preterm-Born Children from 0 to 4 Years: The Role of both Prematurity and SGA Status

Neonatology ◽  
2013 ◽  
Vol 103 (4) ◽  
pp. 293-299 ◽  
Author(s):  
Inger F.A. Bocca-Tjeertes ◽  
Sijmen A. Reijneveld ◽  
Jorien M. Kerstjens ◽  
Andrea F. de Winter ◽  
Arend F. Bos
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Preterm Born

scholarly journals FKBPL and SIRT-1, key angiogenesis proteins, are downregulated by diabetes in pregnancy

2020 ◽  
Author(s):  
Abdelrahim Alqudah ◽  
Kelly-Ann Eastwood ◽  
Djurdja Jerotic ◽  
Naomi Todd ◽  
Denise Hoch ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Protein Expression ◽  
Gestational Age ◽  
High Glucose ◽  
Cell Function ◽  
First Trimester ◽  
Diabetes In Pregnancy ◽  
Endothelial Cell Function ◽  
In Pregnancy

AbstractContextDiabetes in pregnancy is associated with numerous complications, however the mechanisms are still poorly understood.ObjectiveTo investigate the role of new angiogenesis markers, FKBPL and SIRT-1, in pre-gestational (type 1 diabetes, T1D) and gestational diabetes (GDM).Design and interventionPlacental FKBPL, SIRT-1, PlGF and VEGF-R1 protein expression was determined from pregnant women with GDM or T1D, and in first trimester trophoblast cells exposed to high glucose and varying oxygen concentrations. Endothelial cell function was assessed in high glucose conditions and FKBPL overexpression.Settings and ParticipantsHuman placental samples from pregnant women with GDM (n=6) or T1D (n=8) were collected to assess FKBPL and SIRT-1 protein expression compared to non-diabetic controls.Main outcome measuresTo determine the role of placental FKBPL and/or SIRT-1 in diabetic pregnancies, in first trimester trophoblasts and endothelial cell function in high-glucose environment.ResultsPlacental FKBPL protein expression was downregulated in T1D (FKBPL; p<0.05) whereas PlGF/VEGF-R1 were upregulated (p<0.05); correlations adjusted for gestational age were also significant. In the presence of GDM, only SIRT-1 (p<0.001) was significantly downregulated even when adjusted for gestational age (r=-0.92, p=0.001). FKBPL and SIRT-1 were also downregulated in ACH-3P cells in high glucose conditions and 6.5%/2.5% oxygen concentrations (p<0.05). FKBPL overexpression in HUVECs reduced tubule formation compared to empty vector control, in high glucose conditions (junctions; p<0.01, branches; p<0.05).ConclusionsFKBPL and/or SIRT-1 downregulation in response to diabetes may have a role in the development of vascular dysfunction in pregnancy, and associated complications such as preeclampsia.

scholarly journals Role of insulin-like gRowth factoR-1 in fetal and eaRly postnatal gRowth in childRen boRn small foR gestational age

2013 ◽  
Vol 6 (6) ◽  
pp. 36-39
Author(s):  
Kristina F. islamova ◽  
◽  
YurY v . PetrenKo ◽  
DmitrY o. ivanov ◽  
soFia n. FiliPPova ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Postnatal Growth ◽  
Insulin Like Growth Factor
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