scholarly journals Prefrontal Cortical Response to Negative Social Words Links Social Risk to Depressive Symptoms in Adolescence

2018 ◽  
Vol 28 (1) ◽  
pp. 87-102 ◽  
Author(s):  
Kyung Hwa Lee ◽  
Caroline W. Oppenheimer ◽  
Greg J. Siegle ◽  
Cecile D. Ladouceur ◽  
Grace E. Lee ◽  
...  
2010 ◽  
Vol 120 (7) ◽  
pp. 483-488 ◽  
Author(s):  
Richard W. F. Cheng ◽  
Donald S. Borrett ◽  
Weyland Cheng ◽  
Hon C. Kwan ◽  
Richard S. S. Cheng

2021 ◽  
Author(s):  
Julia Gillard ◽  
Siobhan Gormley ◽  
Kirsty Griffiths ◽  
Caitlin Hitchcock ◽  
Jason Stretton ◽  
...  

BackgroundThe risk of depressive relapse and recurrence is amplified by social risk factors including the perception of low social status. MethodsWe aimed to identify enduring difficulties with the perception of social status in a community sample with a self-reported history of mental health difficulties (Study 1) and, more specifically, in individuals in clinical remission from depression, relative to a never-depressed control group, and relative to a group experiencing a current depressive episode (Study 2). ResultsIn Study 1, elevated depressive symptoms were associated with perceptions of low social status which significantly differed between individuals with and without a self-reported history of mental health difficulties. Study 2 found enduring deficits in perceptions of social status in remitted depressed individuals, in the absence of current symptoms. LimitationsWe were unable to discern between historical or current clinical diagnosis in the community sample of Study 1, as we were reliant on self-report. We were unable to explore the effects of medication or causal relationships between depressive symptoms and social status as the studies were cross-sectional in nature. ConclusionsThese findings suggest that disrupted socio-cognitive profiles across a range of affiliative processes may confer increased vulnerability to future depressive episodes in those in remission.


2012 ◽  
Vol 202 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Rebecca Kerestes ◽  
Zubin Bhagwagar ◽  
Pradeep J. Nathan ◽  
Shashwath A. Meda ◽  
Cecile D. Ladouceur ◽  
...  

2016 ◽  
Vol 121 ◽  
pp. 12-18 ◽  
Author(s):  
Stefano Bembich ◽  
Cristina Vecchiet ◽  
Gabriele Cont ◽  
Cristina Sustersic ◽  
Francesca Valencak ◽  
...  

2015 ◽  
Vol 10 (02) ◽  
pp. 087-094 ◽  
Author(s):  
Akiyuki Saotome ◽  
Hiroki Higuchi ◽  
Masaaki Narita ◽  
Mami Tazoe ◽  
Kaoru Sakatani ◽  
...  

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 341-342
Author(s):  
Andrew Petkus ◽  
Xinhui Wang ◽  
Diana Younan ◽  
Daniel Beavers ◽  
Mark Espeland ◽  
...  

Abstract Exposure to air pollution may accelerate brain aging and increase risk of late-life depressive symptoms (DS). Brain structures underlying these associations are unknown. Longitudinal data from 829 community-dwelling women without dementia (baseline age 81.6 ± 3.6 years old) who participated in both the Women’s Health Initiative Memory Study Magnetic Resonance Imaging study (WHIMS-MRI; 2005-06) and the WHIMS-Epidemiology of Cognitive Health Outcomes (2008-16) were analyzed to examine whether volumetric measures of brain structures mediated associations between long-term exposure to ambient air pollutants and annual increases in DS (as measured by annually assessed 15-item Geriatric Depression Scale). Annual PM2.5 (fine particulate matter of aerodynamic diameter <2.5) and NO2 were estimated at the participants’ residence using regionalized universal kriging models and aggregated to the 3-year average prior to the WHIMS-MRI. Structural equation models were constructed to estimate associations between exposure, structural brain variables, and trajectories of DS (standardized on baseline mean and SD). Living in locations with higher NO2 (standardized β = 0.023; 95% Confidence Interval (CI) = 0.004, 0.042) or PM2.5 (standardized β = 0.021; 95% CI = 0.004, 0.038) was associated with larger annual increases in DS (~60% larger annual increase in DS). Higher NO2, but not PM2.5, was associated with smaller prefrontal cortical volumes (standardized β = -0.431; 99% CI = -0.518; -0.344). Prefrontal cortical volume explained 30.4% of the total association between annual DS increase and NO2. These findings underscore the importance of the prefrontal cortex in associations between NO2 exposure and increasing DS in later-life.


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