The clinical utility of contemporary oral epithelial dysplasia grading systems

2021 ◽  
Author(s):  
Hans Prakash Sathasivam ◽  
Philip Sloan ◽  
Peter J Thomson ◽  
Max Robinson
Keyword(s):  
Clinical Utility ◽  
Epithelial Dysplasia ◽  
Oral Epithelial Dysplasia ◽  
Grading Systems ◽  
Oral Epithelial

Oral Epithelial Dysplasia Grading Systems: A Systematic Review & Meta-Analysis

2022 ◽  
pp. 106689692110701
Author(s):  
Zaid H. Khoury ◽  
Mohamed Sultan ◽  
Ahmed S. Sultan
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Observer Agreement ◽  
Epithelial Dysplasia ◽  
Primary Research ◽  
Level Of Evidence ◽  
Minimal Impact ◽  
Oral Epithelial Dysplasia ◽  
Grading Systems ◽  
Oral Epithelial

This systematic review and meta-analysis aims to provide a robust qualitative and quantitative analysis of the different systems used to assess the grade of oral epithelial dysplasia (OED). This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyzes (PRISMA) statement. Six electronic databases were searched for primary research published over the past four decades. Overall quality and level of evidence were based on the Johns Hopkins Research Evidence Appraisal Tool, while evidence of heterogeneity was determined by the Q-statistic and I^2 statistic. Evidence of publication bias was determined using Egger's regression and the Rank correlation tests. A total of 170 records were identified. Only 9 primary research articles were included in the qualitative systematic review. Four studies (4/9) were included in the final quantitative meta-analysis. The grading systems analyzed included the WHO, binary, Ljubljana, Smith and Pindborg, Brothwell, and the oral intraepithelial neoplasia. The results demonstrate the binary system to be superior to the WHO system in grading OED, by providing better inter-observer agreement, however, the substantial error among the inter-observer κ values analyzed indicates the significance of this finding to be of minimal impact. Lack of reliable reproducibility of the grading systems and lack of common effect size (heterogeneity analysis) were noted.

A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis

Oral Diseases ◽  
2016 ◽  
Vol 22 (6) ◽  
pp. 523-529 ◽  
Author(s):  
PR Câmara ◽  
SN Dutra ◽  
A Takahama Júnior ◽  
KBFC Fontes ◽  
RS Azevedo
Keyword(s):  
Comparative Study ◽  
Epithelial Dysplasia ◽  
Actinic Cheilitis ◽  
Oral Epithelial Dysplasia ◽  
Grading Systems ◽  
Oral Epithelial

scholarly journals An Insight to Oral Epithelial Dysplasia

2013 ◽  
Vol 4 (2) ◽  
pp. 74-82 ◽  
Author(s):  
Varun Rastogi ◽  
Naveen Puri ◽  
Satyaranjan Mishra ◽  
Swati Arora ◽  
Geetpriya Kaur ◽  
...  
Keyword(s):  
Histological Grade ◽  
Precancerous Lesion ◽  
Epithelial Dysplasia ◽  
Oral Dysplasia ◽  
Oral Epithelial Dysplasia ◽  
Grading Systems ◽  
Risk Of Progression ◽  
Cytological Changes ◽  
Oral Epithelial ◽  
Head Neck

ABSTRACT Oral dysplasia is a potentially precancerous lesion diagnosed histologically. While the risk of progression is associated with histological grade, it is currently impossible to predict accurately which lesions will progress. Although most oral pathologists recognize and accept the criteria for grading epithelial dysplasia based on architectural and cytological changes, there can be considerable interexaminer and intraexaminer variation in the assessment of the presence or absence and the grade of oral epithelial dysplasia. This article reviews the alterations, criteria, different grading systems and the markers used for assessing the malignant transformation of epithelial dysplasia. How to cite this article Rastogi V, Puri N, Mishra S, Arora S, Kaur G, Yadav L. An Insight to Oral Epithelial Dysplasia. Int J Head Neck Surg 2013;4(2):74-82.

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