Identification of pivotal microRNAs involved in the development and progression of Salivary Adenoid Cystic Carcinoma

2021 ◽  
Author(s):  
Qing‐hai Zhu ◽  
Ying Meng ◽  
Yu‐ting Tang ◽  
Chen‐xing Hou ◽  
Nan‐nan Sun ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Salivary Adenoid Cystic Carcinoma ◽  
Adenoid Cystic

scholarly journals The utility of TP53 and PIK3CA mutations as prognostic biomarkers in salivary adenoid cystic carcinoma

Oral Oncology ◽  
2021 ◽  
Vol 113 ◽  
pp. 105095
Author(s):  
Helen Adderley ◽  
Samuel Rack ◽  
Brindley Hapuarachi ◽  
Laura Feeney ◽  
David Morgan ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Prognostic Biomarkers ◽  
Salivary Adenoid Cystic Carcinoma ◽  
Pik3ca Mutations ◽  
Adenoid Cystic

Cisplatin and 5-fluorouracil for symptom control in advanced salivary adenoid cystic carcinoma

Oral Oncology ◽  
1997 ◽  
Vol 33 (4) ◽  
pp. 275-278 ◽  
Author(s):  
M HILL ◽  
D CONSTENLA ◽  
R AHERN ◽  
J HENK ◽  
P RHYSEVANS ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Symptom Control ◽  
Salivary Adenoid Cystic Carcinoma ◽  
Adenoid Cystic

scholarly journals Addendum to Bell et al's “In-depth characterization of the salivary adenoid cystic carcinoma transcriptome with emphasis on dominant cell type”

Cancer ◽  
2016 ◽  
Vol 122 (14) ◽  
pp. 2278-2279 ◽  
Author(s):  
Diana Bell ◽  
Achim H. Bell ◽  
Jolanta Bondaruk ◽  
Ehab Y. Hanna ◽  
Randall S. Weber
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Cell Type ◽  
Salivary Adenoid Cystic Carcinoma ◽  
Adenoid Cystic

Expression of c-kit and Slug correlates with invasion and metastasis of salivary adenoid cystic carcinoma

Oral Oncology ◽  
2010 ◽  
Vol 46 (4) ◽  
pp. 311-316 ◽  
Author(s):  
Yaling Tang ◽  
Xinhua Liang ◽  
Min Zheng ◽  
Zhiyu Zhu ◽  
Guiquan Zhu ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Invasion And Metastasis ◽  
Salivary Adenoid Cystic Carcinoma ◽  
Adenoid Cystic

scholarly journals Expression of RUNX3 in salivary adenoid cystic carcinoma: Implications for tumor progression and prognosis

2008 ◽  
Vol 99 (7) ◽  
pp. 1334-1340 ◽  
Author(s):  
Jian-Feng He ◽  
Ming-Hua Ge ◽  
Xin Zhu ◽  
Chao Chen ◽  
Zhuo Tan ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Adenoid Cystic Carcinoma ◽  
Adenoid Cystic

High Expression of H3K9me3 Is a Strong Predictor of Poor Survival in Patients With Salivary Adenoid Cystic Carcinoma

2013 ◽  
Vol 137 (12) ◽  
pp. 1761-1769 ◽  
Author(s):  
Ronghui Xia ◽  
Rongrui Zhou ◽  
Zhen Tian ◽  
Chunye Zhang ◽  
Lizhen Wang ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Distant Metastasis ◽  
Survival Data ◽  
Histone H3 ◽  
Disease Free Survival ◽  
Rank Test ◽  
Free Survival ◽  
Salivary Adenoid Cystic Carcinoma ◽  
Adenoid Cystic ◽  
Disease Free

Context.—Histone methylation and acetylation play important roles in the carcinogenesis and progression of cancer. Objective.—To investigate whether histone modifications influence the prognosis of patients with salivary adenoid cystic carcinoma (ACC). Design.—The expression of histone H3 lysine 9 trimethylation (H3K9me3) and histone H3 lysine 9 acetylation (H3K9Ac) was assessed by immunohistochemistry in 66 specimens of primary ACC. Tests were used to determine the presence of any correlation between H3K9me3 and H3K9Ac levels and clinicopathologic parameters. Log-rank test and Cox proportional hazards regression models were used to analyze the survival data. Results.—H3K9me3 expression was positively correlated with solid pattern tumors (P = .002) and distant metastasis (P = .001). Solid pattern tumors had lower H3K9Ac expression levels than cribriform-tubular pattern tumors (P = .03). Patients whose tumors showed high H3K9me3 expression and a solid pattern had a significantly poorer overall survival (OS) (P < .001 and P < .001, respectively) and disease-free survival (P < .001 and P = .01, respectively). Low H3K9Ac expression was correlated with poor OS (P = .05). The multivariate analysis indicated that high levels of H3K9me3 expression and solid pattern tumors were independent prognostic factors that significantly influenced OS (P = .004 and P = .04, respectively). H3K9me3 expression was identified as the only independent predictor of disease-free survival (P = .006). Conclusions.—Our results suggest that high levels of H3K9me3 expression are predictive of rapid cell proliferation and distant metastasis in ACC. Compared with histologic patterns, H3K9me3 might be a better predictive biomarker for the prognosis of patients with salivary ACC.

scholarly journals Microfluidic Analyzer Enabling Quantitative Measurements of Specific Intracellular Proteins at the Single-Cell Level

Micromachines ◽  
2018 ◽  
Vol 9 (11) ◽  
pp. 588 ◽  
Author(s):  
Lixing Liu ◽  
Beiyuan Fan ◽  
Diancan Wang ◽  
Xiufeng Li ◽  
Yeqing Song ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Single Cell ◽  
Cell Line ◽  
Oral Carcinoma ◽  
Parental Cell Line ◽  
Single Cell Level ◽  
Cell Level ◽  
Salivary Adenoid Cystic Carcinoma ◽  
Adenoid Cystic ◽  
Intracellular Proteins

This paper presents a microfluidic instrument capable of quantifying single-cell specific intracellular proteins, which are composed of three functioning modules and two software platforms. Under the control of a LabVIEW platform, a pressure module flushed cells stained with fluorescent antibodies through a microfluidic module with fluorescent intensities quantified by a fluorescent module and translated into the numbers of specific intracellular proteins at the single-cell level using a MATLAB platform. Detection ranges and resolutions of the analyzer were characterized as 896.78–6.78 × 105 and 334.60 nM for Alexa 488, 314.60–2.11 × 105 and 153.98 nM for FITC, and 77.03–5.24 × 104 and 37.17 nM for FITC-labelled anti-beta-actin antibodies. As a demonstration, the numbers of single-cell beta-actins of two paired oral tumor cell types and two oral patient samples were quantified as: 1.12 ± 0.77 × 106/cell (salivary adenoid cystic carcinoma parental cell line (SACC-83), ncell = 13,689) vs. 0.90 ± 0.58 × 105/cell (salivary adenoid cystic carcinoma lung metastasis cell line (SACC-LM), ncell = 15,341); 0.89 ± 0.69 × 106/cell (oral carcinoma cell line (CAL 27), ncell = 7357) vs. 0.93 ± 0.69 × 106/cell (oral carcinoma lymphatic metastasis cell line (CAL 27-LN2), ncell = 6276); and 0.86 ± 0.52 × 106/cell (patient I) vs. 0.85 ± 0.58 × 106/cell (patient II). These results (1) validated the developed analyzer with a throughput of 10 cells/s and a processing capability of ~10,000 cells for each cell type, and (2) revealed that as an internal control in cell analysis, the expressions of beta-actins remained stable in oral tumors with different malignant levels.

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