Knockdown of lncRNA IGF2BP2‐AS1 inhibits proliferation and migration of oral squamous cell carcinoma cells via the Wnt/β‐catenin pathway

2021 ◽  
Author(s):  
Shuqing Tong ◽  
Xiaoyang Wang ◽  
Xiangrui Guo ◽  
Zhiming Lu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Celastrus orbiculatus Celastraceae Thunb extracts inhibit proliferation and migration of oral squamous cell carcinoma cells by blocking NF-κB pathway

2021 ◽  
Vol 18 (6) ◽  
pp. 1259-1264
Author(s):  
Deqiang Hou ◽  
Ning Bai ◽  
Zicheng Wei ◽  
Bang Li ◽  
Genxiong Tang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Migration ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Migration And Invasion ◽  
Celastrus Orbiculatus ◽  
And Migration ◽  
Proliferation And Migration

Purpose: To investigate the mechanism of action of Celastrus orbiculatus extract (COE) on oral squamous carcinoma cells. Methods: Tca8113 cells were divided into negative control and three COE treatment groups, viz, 20, 40, and 80 μg/mL of COE. Succinate dehydrogenase activity assay (MTT assay) and flow cytometry were used to assess cell proliferation and apoptosis. Cell migration and invasion were assessed by Transwell chamber and wound healing assays while relative protein expression was determined by Western blot. Results: As the concentration of COE increased, the number of cells arrested in the G0/G1 phase increased (p < 0.05), expressions of cell-cycle-related proteins decreased (p < 0.001); the number of apoptotic cells increased (p < 0.001), and the rates of cell migration and invasion decreased (p < 0.001). Exogenous COE significantly inhibited p-IκBα accumulation in the cytoplasm and induced IκBα accumulation. Nuclear p65 recruitment was reduced in cells treated with COE compared to untreated control cells (p < 0.001), suggesting that the classical NF-κB pathway was blocked by COE. Conclusion: These results demonstrate that COE inhibits the proliferation and migration of oral squamous cell carcinoma cells while promoting apoptosis by blocking NF-κB pathway. These findings suggest that Celastrus orbiculatus extract possesses a potential therapeutic effect on oral squamous cell carcinoma.

scholarly journals Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Gustavo A Acuña Sanhueza ◽  
Leonie Faller ◽  
Babitha George ◽  
Jennifer Koffler ◽  
Vinko Misetic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma ◽  
And Migration ◽  
Proliferation And Migration
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