Prevalence of oral mucosal lesions in patients with pemphigus vulgaris: A systematic review and meta‐analysis

2021 ◽  
Author(s):  
Elis Ângela Batistella ◽  
Rayssa Sabino da Silva ◽  
Elena Riet Correa Rivero ◽  
Carolina Amália Barcellos Silva
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Pemphigus Vulgaris ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions

A Systematic Review and Meta-Analysis of HLA-Class-II Associations in Patients with IgG4 Autoimmunity

2021 ◽  
Author(s):  
Anja Panhuber ◽  
Giovanni Lamorte ◽  
Veronica Bruno ◽  
Hakan Cetin ◽  
Wolfgang Bauer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Autoimmune Diseases ◽  
Genetic Risk ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
Pemphigus Vulgaris ◽  
Case Control ◽  
Case Control Studies ◽  
Leukocyte Antigen ◽  
Susceptibility Factors

Abstract Autoimmune diseases caused by pathogenic IgG4 subclass autoantibodies (IgG4-AID) include diseases like MuSK myasthenia gravis, pemphigus vulgaris or thrombotic thrombocytopenic purpura. Their etiology is still unknown. Polymorphisms in the human leukocyte antigen (HLA) gene locus, particularly in HLA-DRB1, are known genetic susceptibility factors for autoimmune diseases. We hypothesized a similar role for HLA polymorphisms in IgG4-AID and conducted a systematic review and meta-analysis with case-control studies on IgG4-AID based on MOOSE/ HuGENet guidelines. Genotype (G) and allele (A) frequencies of HLA-DQB1*05 (G: OR 3.8; 95% CI 2.44-5.9; p < 0.00001; A: OR 2.54; 95% CI 1.82-3.55; p < 0.00001) and HLA-DRB1*14 (G: OR 4.31; 95% CI 2.82-6.59; p < 0.00001; A: OR 4.78; 95% CI 3.52-6.49; p < 0.00001) and the HLA-DRB1*14-DQB1*05 haplotype (OR 6.3; 95% CI 3.28-12.09; p < 0.00001 / OR 4.98; 95% CI 3.8-6.53; p < 0.00001) were increased while HLA-DRB1*13 (G: OR 0.48; 95% CI 0.34-0.68; p < 0.0001; A: OR 0.46; 95% CI 0.34-0.62; p < 0.00001) was decreased in IgG4-AID patients. In conclusion, the HLA-DQB1*05, HLA-DRB1*14 alleles and the HLA-DQB1*05-DRB1*14 haplotype could be genetic risk factors that predispose for the production of pathogenic IgG4 autoantibodies and the HLA-DRB1*13 allele may protect from IgG4 autoimmunity.

Treatment of Pemphigus Vulgaris and Pemphigus Foliaceus: A Systematic Review and Meta-Analysis

2014 ◽  
Vol 15 (6) ◽  
pp. 503-515 ◽  
Author(s):  
Lihi Atzmony ◽  
Emmilia Hodak ◽  
Michael Gdalevich ◽  
Omer Rosenbaum ◽  
Daniel Mimouni
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Pemphigus Vulgaris ◽  
Pemphigus Foliaceus

scholarly journals Oral Manifestations in Patients with COVID-19: A Living Systematic Review

2020 ◽  
pp. 002203452095728 ◽  
Author(s):  
J. Amorim dos Santos ◽  
A.G.C. Normando ◽  
R.L. Carvalho da Silva ◽  
A.C. Acevedo ◽  
G. De Luca Canto ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Reports ◽  
Signs And Symptoms ◽  
Clinical Aspects ◽  
Cross Sectional ◽  
Oral Manifestation ◽  
Oral Mucosal Lesions ◽  
Taste Disorders ◽  
Mucosal Lesions ◽  
Erythematous Plaques

This living systematic review aims to summarize evidence on the prevalence of oral signs and symptoms in patients with COVID-19. The review was reported per the PRISMA checklist, and the literature search was conducted in 6 databases and in gray literature. Studies published in any language mentioning oral symptoms and signs in patients with COVID-19 were included. The risk of bias was assessed by the Joanna Briggs Institute appraisal tools. The certainty of evidence was evaluated through GRADE assessment. After a 2-step selection, 40 studies were included: 33 cross-sectional and 7 case reports. Overall, 10,228 patients (4,288 males, 5,770 females, and 170 unknown) from 19 countries were assessed. Gustatory impairment was the most common oral manifestation, with a prevalence of 45% (95% CI, 34% to 55%; I2 = 99%). The pooled eligible data for different taste disorders were 38% for dysgeusia and 35% for hypogeusia, while ageusia had a prevalence of 24%. Taste disorders were associated with COVID-19 (odds ratio [OR], 12.68; 95% CI, 6.41 to 25.10; I2 = 63%; P < 0.00001), mild/moderate severity (OR, 2.09; 95% CI, 1.25 to 3.49; I2 = 66%; P = 0.005), and female patients (OR, 1.64; 95% CI, 1.23 to 2.17; I2 = 70%; P = 0.0007). Oral mucosal lesions presented multiple clinical aspects, including white and erythematous plaques, irregular ulcers, small blisters, petechiae, and desquamative gingivitis. Tongue, palate, lips, gingiva, and buccal mucosa were affected. In mild cases, oral mucosal lesions developed before or at the same time as the initial respiratory symptoms; however, in those who required medication and hospitalization, the lesions developed approximately 7 to 24 d after onset symptoms. Therefore, taste disorders may be common symptoms in patients with COVID-19 and should be considered in the scope of the disease’s onset and progression. Oral mucosal lesions are more likely to present as coinfections and secondary manifestations with multiple clinical aspects (PROSPERO CRD42020184468).

Topical photodynamic therapy in the treatment of benign oral mucosal lesions: A systematic review

2020 ◽  
Author(s):  
Antonio Romano ◽  
Dario Di Stasio ◽  
Dorina Lauritano ◽  
Carlo Lajolo ◽  
Fausto Fiori ◽  
...  
Keyword(s):  
Systematic Review ◽  
Photodynamic Therapy ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions

scholarly journals Oral mucosal lesions in patients with pemphigus and pemphigoid skin diseases: a cross sectional study from southern India.

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Arvind Babu Rajendra Santosh ◽  
Venkat Ramana Reddy Baddam ◽  
Chigurupati Anuradha ◽  
Chandrashekar Poosarla
Keyword(s):  
Skin Diseases ◽  
Disease Process ◽  
Pemphigus Vulgaris ◽  
Diagnostic Procedures ◽  
Cross Sectional Study ◽  
Southern India ◽  
Cross Sectional ◽  
Autoimmune Blistering Disease ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions

Objective:To assess the prevalence of oral mucosal lesions in patients with pemphigus and pemphigoid diseases from Southern India. Design and Methods: A cross-sectional hospital based study was conducted from August 2010 to July 2011. Patients with confirmed pemphigus and pemphigoid skin disease were selected and informed to participate in the study. Oral examination of all participants were done to document site and type of oral manifestation and diagnostic procedures such as histopathological and Immunofluorescence methods were performed to confirm the diagnosis. Demographic details such as age, gender and occupation were also documented. The results of the study were analyzed by SPSS software version 19.0 (Armonk, NY) and presented as descriptive statistics. Results: Sixty percent of the patients exhibited oral mucosal manifestations. A higher female (86.66%) predilection of autoimmune blistering disease was observed in the study. A slightly higher number of pemphigoid patients (53.33%, 16 out of 30) were reported than pemphigus (46.66%, 14 out of 30 cases). The most common subtypes of pemphigus is Pemphigus vulgaris 71% (10 out of 14) among pemphigus, and bullous pemphigoid 87.5%(14 out of 16) among pemphigoid. Buccal mucosa (92.85%) is the most common site in pemphigus patients, where as hard palate (12.5%) is mostly commonly reported site in pemphigoid patients. Initial involvement of oral tissue in disease process was observed in 78.57% of pemphigus, and 12.5% of pemphigoid patients. Conclusion: Oral mucosal lesions are more frequently associated in pemphigus patients. Oral mucosal lesions are the initial site of disease process in pemphigus patients. The significance of diagnosis of oral lesions at earlier stage of disease, specifically pemphigus may help in early intervention of disease and help to reduce the morbidity and mortality state. The study emphasizes multidisciplinary approach in diagnosis and management of both pemphigus and pemphigoid.

Sign in / Sign up

Export Citation Format

Share Document