The prognostic role of tumour‐infiltrating lymphocytes in oral squamous cell carcinoma: A meta‐analysis

2019 ◽  
Vol 48 (9) ◽  
pp. 788-798 ◽  
Author(s):  
Zhengxian Huang ◽  
Nan Xie ◽  
Haichao Liu ◽  
Yuehan Wan ◽  
Yue Zhu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Meta Analysis ◽  
Prognostic Role ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

Comprehensive study on the prognostic role of osteopontin expression in oral squamous cell carcinoma

Oral Oncology ◽  
2009 ◽  
Vol 45 (9) ◽  
pp. 798-802 ◽  
Author(s):  
Chih-Yen Chien ◽  
Chih-Ying Su ◽  
Hui-Ching Chuang ◽  
Fu-Min Fang ◽  
Hsuan-Ying Huang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Role ◽  
Osteopontin Expression ◽  
Comprehensive Study

Clinicopathological and Prognostic Significance of p27 Expression in Oral Squamous Cell Carcinoma: A Meta-Analysis

2013 ◽  
Vol 28 (4) ◽  
pp. 329-335 ◽  
Author(s):  
Ling Gao ◽  
Wanjie Gu ◽  
Jingjing Zheng ◽  
Wenhao Ren ◽  
Su'e Chang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Publication Bias ◽  
Squamous Cell ◽  
Meta Analysis ◽  
Clinicopathological Parameters ◽  
Lymph Node Status

Despite being already known that p27 can regulate cell proliferation, cell motility and apoptosis, the role of p27 expression in oral squamous cell carcinoma (OSCC) remains controversial. The purpose of this study was to comprehensively evaluate, with a meta-analysis, the clinicopathological and prognostic role of p27 expression in OSCC. A meta-analysis of eligible studies was performed to assess the effects of p27 expression on clinicopathological parameters and overall survival (OS) in patients with OSCC, using pooled relative risks with 95% confidence intervals. Heterogeneity and publication bias were also assessed. Fourteen studies involving a total of 1,010 patients met the inclusion criteria. Low p27 expression was significantly associated with advanced TNM stage (p<0.001), worse histology (p=0.025), and lymph node metastasis (p<0.001), but not with tumor size (p=0.181). The pooled RR of 0.743 (p=0.002) suggested that low p27 expression has a poor prognosis in patients with OSCC. A significant heterogeneity among studies was detected for lymph node status (χ2=34.60, I2=68.2%, p<0.001) and OS (χ2=14.86, I2=39.4%, p=0.095). We did not detect a significant publication bias in this meta-analysis. Our meta-analysis suggests that p27 expression status might be useful as a predictive biomarker in clinical practice, and might potently predict OS in OSCC patients.

scholarly journals T cell receptor Vα and Vβ gene usage by tumour-infiltrating lymphocytes in oral squamous cell carcinoma

1997 ◽  
Vol 45 (1) ◽  
pp. 61-61
Author(s):  
Takefumi Mouri ◽  
Seiji Nakamura ◽  
Yukiko Ohyama ◽  
Goro Matsuzaki ◽  
Masanori Shinohara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Cell ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
T Cell Receptor ◽  
Squamous Cell ◽  
Cell Receptor ◽  
Gene Usage ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

scholarly journals The prognostic significance of tumour infiltrating lymphocytes in oral squamous cell carcinoma

2019 ◽  
Vol 70 (4) ◽  
pp. 277-285
Author(s):  
Mariusz Książek ◽  
Bogumił Lewandowski ◽  
Robert Brodowski ◽  
Paweł Pakla ◽  
Marta Kawalec-Książek ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

scholarly journals Prognostic Potential of Tumor-Infiltrating Immune Cells in Resectable Oral Squamous Cell Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2268
Author(s):  
Ana Caruntu ◽  
Liliana Moraru ◽  
Mihai Lupu ◽  
Florina Vasilescu ◽  
Marius Dumitrescu ◽  
...  
Keyword(s):  
Patient Outcome ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Immune Cells ◽  
Prognostic Role ◽  
Immune Microenvironment ◽  
Improved Outcome

(1) Background: The immune microenvironment plays an important role in carcinogenesis and has prognostic potential in many types of cancer. In this study we assess the prognostic character of tumor-infiltrating immune cells CD4+, CD8+ and CD56+ in resectable oral squamous cell carcinoma (OSCC); (2) Methods: We have evaluated the densities of CD4+, CD8+ and CD56+ in two distinct compartments, intratumor and invasion front, in 90 patients with OSCC; (3) Results: Significant differences were found between the tumor compartments for the CD4+ and CD8+ lymphocytes. An improved outcome (OS) was seen in patients with high densities of intratumor CD8+ lymphocytes (p = 0.0086), CD8+ lymphocytes at the front of invasion (p = 0.0011) and for intratumor CD56+ cells (p = 0.0016). Multivariate analysis confirmed the independent prognostic role of CD8+ at the front of invasion (OR = 3.75, CI95% 1.17–12.35, p = 0.026) and for intratumor CD56+ cells (OR = 3.669, CI95% 1.09–15.37, p = 0.035); (4) Conclusions: Tumor-infiltrating CD8+ lymphocytes at the front of invasion and CD56+ in the intratumor compartment display predictive traits in OSCC. A reach immune infiltration with these types of cells is associated with an improved patient outcome.

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