Does Hypoxia-Inducible Factor -1 α (HIF-1α) C1772T polymorphism predict short-term prognosis in patients with oral squamous cell carcinoma (OSCC)?

2018 ◽  
Vol 47 (7) ◽  
pp. 660-664 ◽  
Author(s):  
Jitender Prasad ◽  
Binita Goswami ◽  
Srinivas H. Gowda ◽  
Nikhil Gupta ◽  
Shilpa Kumar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hypoxia Inducible Factor ◽  
Short Term ◽  
Hypoxia Inducible Factor 1

scholarly journals Hypoxia-inducible factor 1 alpha in oral squamous cell carcinoma and its relation to prognosis

Oral Oncology ◽  
2009 ◽  
Vol 45 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Masataka Uehara ◽  
Kazuo Sano ◽  
Hisazumi Ikeda ◽  
Mihoko Nonaka ◽  
Izumi Asahina
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1

scholarly journals Effect of Areca Nut Consumption on Hypoxia-inducible Factor-1 Alfa Expression in Patients with Oral Squamous Cell Carcinoma

2017 ◽  
Vol 21 (2) ◽  
pp. 81-85 ◽  
Author(s):  
Kiran Agarwal ◽  
Anju Chauhan ◽  
Jitender Prasad ◽  
Pravesh Mehra ◽  
Shilpa Kumar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hypoxia Inducible Factor ◽  
Common Finding ◽  
Enzyme Linked Immunosorbent Assay ◽  
Areca Nut ◽  
Major Health ◽  
Hypoxia Inducible Factor 1

ABSTRACT Introduction Oral squamous cell carcinoma (OSCC) is a major health problem in Southeast Asia, including India. Areca nut chewing is a major health hazard in India, which has been implicated in the etiology of OSCC. Hypoxia-inducible factor-1 (HIF-1) is a major transcription factor involved in adaptation under hypoxic condition, a common finding in solid tumors. The present study was conducted to evaluate the effect of different habits including areca nut chewing on HIF-1 expression in patients with OSCC. Materials and methods It was a hospital-based observational case-control study. The study comprised 50 histologically proven cases of OSCC and 50 healthy controls. The HIF-1α level was measured by commercially available enzyme-linked immunosorbent assay (ELISA) in the blood samples. The data were analyzed using Statistical Package for the Social Sciences (SPSS) software version 20. Results The HIF-1α levels were found significantly higher in the patients with areca nut consumption in addition to other addictive habits. Isolated influence could not be discerned as there was only one patient who gave history of only areca nut chewing. Conclusion Our findings prove that HIF-1α expression is upregulated by areca nut chewing, which leads to worse prognosis. This calls for widespread awareness programs regarding the deleterious effects of areca nut chewing among the general population. How to cite this article Prasad J, Goswami B, Agarwal K, Mehra P, Kumar S, Pahuja BK, Chauhan A, Ahirwar AK. Effect of Areca Nut Consumption on Hypoxia-inducible Factor-1 Alfa Expression in Patients with Oral Squamous Cell Carcinoma. Indian J Med Biochem 2017;21(2):81-85.

scholarly journals Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma

2020 ◽  
Vol 21 (17) ◽  
pp. 6083
Author(s):  
Alexander W. Eckert ◽  
Matthias Kappler ◽  
Ivo Große ◽  
Claudia Wickenhauser ◽  
Barbara Seliger
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hypoxia Inducible Factor ◽  
Therapy Resistance ◽  
Nutrient Utilization ◽  
Tnm System ◽  
Hypoxia Inducible Factor 1 ◽  
Human Malignancy

Oral squamous cell carcinoma (OSCC) is the 10th most frequent human malignancy and is thus a global burden. Despite some progress in diagnosis and therapy, patients’ overall survival rate, between 40 and 55%, has stagnated over the last four decades. Since the tumor node metastasis (TNM) system is not precise enough to predict the disease outcome, additive factors for diagnosis, prognosis, prediction and therapy resistance are urgently needed for OSCC. One promising candidate is the hypoxia inducible factor-1 (HIF-1), which functions as an early regulator of tumor aggressiveness and is a key promoter of energy adaptation. Other parameters comprise the composition of the tumor microenvironment, which determines the availability of nutrients and oxygen. In our opinion, these general processes are linked in the pathogenesis of OSCC. Based on this assumption, the review will summarize the major features of the HIF system-induced activities, its target proteins and related pathways of nutrient utilization and metabolism that are essential for the initiation, progression and therapeutic stratification of OSCC.

Siah-1 is associated with expression of hypoxia-inducible factor-1α in oral squamous cell carcinoma

2017 ◽  
Vol 44 (2) ◽  
pp. 213-219 ◽  
Author(s):  
Mitsuharu Aga ◽  
Satoru Kondo ◽  
Naohiro Wakisaka ◽  
Makiko Moriyama-Kita ◽  
Kazuhira Endo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1Α
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