The potential role of in vivo optical coherence tomography for evaluating oral soft tissue: A systematic review

Author(s):  
Enrica Gentile ◽  
Claudio Maio ◽  
Antonio Romano ◽  
Luigi Laino ◽  
Alberta Lucchese
Author(s):  
Julia Walther ◽  
Jonas Golde ◽  
Marius Albrecht ◽  
Bryden Quirk ◽  
Loretta Scolaro ◽  
...  

2020 ◽  
Author(s):  
Sohaib R Rufai ◽  
Noor ul Owase Jeelani ◽  
Rebecca J McLean

Abstract Introduction Craniosynostosis is characterised by the premature fusion of cranial sutures. This can be associated with raised intracranial pressure (ICP), which can lead to developmental delay, visual impairment and death. Treatment involves surgical expansion of the skull vault. There is no consensus over who to treat and when. Intracranial pressure is difficult to estimate in a child and existing methods possess sub-optimal diagnostic accuracy to be employed as screening tools. Here, we propose a systematic review protocol to examine the role of optical coherence tomography (OCT) in early detection of raised ICP in craniosynostosis. Methods Electronic searches in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and Embase will identify studies featuring OCT in detecting raised ICP in children with craniosynostosis. Two independent researchers will identify studies for inclusion using a screening questionnaire. Quality will be assessed using the National Institutes of Health (NIH) Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. The primary outcome measure is the sensitivity and specificity of OCT in detecting raised ICP in children with craniosynostosis. Secondary outcomes measures include the sensitivity and specificity of other surrogate measures for raised ICP, OCT parameters used and normal ranges for ICP reported. A formal narrative synthesis with descriptive statistics will be presented. Discussion The proposed study will be the first to examine the role of optical coherence tomography in the early recognition of raised intracranial pressure in craniosynostosis, thereby addressing an important clinical problem in paediatric ophthalmology and craniofacial surgery. This systematic review protocol provides transparency to the proposed methods and reduces the possibility of duplication. The proposed methods reflect those prescribed by the Cochrane Collaboration. Systematic review registration International Prospective Register for Systematic Reviews (PROSPERO) number CRD42019147693


2006 ◽  
Vol 29 (6) ◽  
pp. 1039-1045 ◽  
Author(s):  
Vikramaditya Prabhudesai ◽  
Cordelia Phelan ◽  
Ying Yang ◽  
Ruikang K. Wang ◽  
Mark G. Cowling

Diagnostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 827
Author(s):  
Marius Albrecht ◽  
Christian Schnabel ◽  
Juliane Mueller ◽  
Jonas Golde ◽  
Edmund Koch ◽  
...  

To date, there is still a lack of reliable imaging modalities to improve the quality of consultation, diagnostic and medical examinations of the oral mucosa in dentistry. Even though, optical technologies have become an important element for the detection and treatment of different diseases of soft tissue, for the case of oral screenings the evidence of the benefit in comparison to conventional histopathology is mostly still pending. One promising optical technology for oral diagnostics is optical coherence tomography (OCT). To prove the potential of OCT, even the amount of freely accessible OCT data is not sufficient to describe the variance of healthy human oral soft tissue in vivo. In order to remedy this deficiency, the present study provides in vivo OCT cross sections of the human oral mucosa of the anterior and posterior oral cavity as well as the oropharynx of 47 adult volunteers. A collection of representative OCT cross sections forms the basis for a randomized blinded image analysis by means of seven criteria to assess the main features of the superficial layers of the human oral mucosa and to determine its correlation to regional features known from hematoxylin and eosin (HE) stained histology.


2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Sarwat Salim

The anterior segment optical coherence tomography provides an objective method to assess the anterior segment of the eye, including the anatomy of the anterior chamber angle. This technology allows both qualitative and quantitative analyses of the angle and has shown potential in detecting and managing angle-closure glaucoma. In addition, it has a role in identifying pathology in some forms of secondary open-angle glaucoma and postsurgical management of glaucoma. Limitations of this technology include its cost and inability to visualize well structures posterior to the iris, such as the ciliary body. This paper focuses on potential benefits and limitations of anterior segment optical coherence tomography when compared with conventional gonioscopy and ultrasound biomicroscopy. Various clinical entities will be described to discuss its potential role in glaucoma practice.


2016 ◽  
Vol 45 (10) ◽  
pp. 723-729 ◽  
Author(s):  
Alberta Lucchese ◽  
Enrica Gentile ◽  
Antonio Romano ◽  
Claudio Maio ◽  
Luigi Laino ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document