Lactate dehydrogenase as a biomarker in oral cancer and oral submucous fibrosis

2016 ◽  
Vol 45 (9) ◽  
pp. 687-690 ◽  
Author(s):  
Basavaraj N. Kallalli ◽  
Kamala Rawson ◽  
Muzammil ◽  
Ankur Singh ◽  
Mohammed Arif Awati ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Oral Cancer ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis

scholarly journals Study of the Role of Salivary Lactate Dehydrogenase in Habitual Tobacco Chewers, Oral Submucous Fibrosis and Oral Cancer as a Biomarker

2019 ◽  
Vol 20 (8) ◽  
pp. 970-973 ◽  
Author(s):  
Sanjay G Thete ◽  
Tejashree Mantri ◽  
Vijayalaxmi Male ◽  
Renu Yadav ◽  
Ishita Grover ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Oral Cancer ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis

scholarly journals Level of serum lactate dehydrogenase in oral submucous fibrosis

2016 ◽  
Vol 2 (4) ◽  
pp. 234 ◽  
Author(s):  
K. Mallikarjuna Swamy ◽  
Arati Ganiger
Keyword(s):  
Lactate Dehydrogenase ◽  
Oral Cancer ◽  
Oral Submucous Fibrosis ◽  
Venous Blood ◽  
Serum Lactate ◽  
Premalignant Lesion ◽  
Serum Lactate Dehydrogenase ◽  
Healthy Controls ◽  
Submucous Fibrosis ◽  
The Relationship

<p class="abstract"><strong>Background:</strong> Oral cancer is one of the most common form of malignancies in India. In many cases it develops at the site of premalignant lesion. Of all oral premalignant conditions, oral submucous fibrosis (OSMF) is of greater concern because of its disabling nature and relative greater chances of malignant transformation. Transformation of normal tissue to premalignant lesion and further to oral cancer results in alteration in glycolytic pathway and hence the lactate dehydrogenase (LDH) levels. The aim of this study was to estimate the LDH levels in serum of subjects with OSMF and to compare them with healthy controls and to correlate the relationship between pathogenesis of OSMF and the LDH enzyme.</p><p class="abstract"><strong>Methods:</strong> It is a case control study. The study included 40 diagnosed cases of OSMF and 40 matched healthy controls. Venous blood of 3 ml was collected in both cases and controls. Serum was separated by centrifugation and LDH was estimated by using standard kits. Statistical analysis was done using student ‘t’ test. Pearson's correlation was performed to establish the relationship between study variables.  </p><p class="abstract"><strong>Results:</strong> It was observed that serum LDH levels were significantly increased in cases of OSMF as compared to controls (p &lt;0.005).</p><p><strong>Conclusions:</strong> Serum LDH was significantly increased in OSMF and can be used as a valuable biochemical marker in prognosis of OSMF.</p>

scholarly journals Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Gopinath Thilak Parepady Sundar ◽  
Vishwanath Sherigar ◽  
Sameep S. Shetty ◽  
Shree Satya ◽  
Sourabh M. Gohil
Keyword(s):  
Oral Cancer ◽  
Perineural Invasion ◽  
Oral Submucous Fibrosis ◽  
Inferior Alveolar Nerve ◽  
Mandibular Canal ◽  
Distinct Disease ◽  
Nerve Tracts ◽  
Submucous Fibrosis ◽  
Neurological Disturbance ◽  
Shed Light

Perineural invasion is an underrecognized route of metastatic spread along the nerve bundles within the nerve sheath into the surrounding tissues. It hinders the ability to establish local control as tumour cells can traverse along nerve tracts well beyond the extent of any local invasion rendering them inoperable and unresectable. Perineural invasion is a marker of poor prognosis. Oral submucous fibrosis with oral cancer constitutes a clinicopathologically distinct disease. Our case highlights an enigmatic presentation of oral submucous fibrosis and its coexistence with oral cancer presenting with unusual neurological disturbance of the inferior alveolar nerve and facial nerve and diffuse widening of the mandibular canal. The objective of this case report is to enumerate the significance of perineural invasion in determining the course of the disease and necessitate the need for future studies that can shed light on molecular mediators and pathogenesis of perineural spread.

scholarly journals Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis

2020 ◽  
Vol 21 (21) ◽  
pp. 8104
Author(s):  
Ru-Hsiu Cheng ◽  
Yi-Ping Wang ◽  
Julia Yu-Fong Chang ◽  
Yu-Hwa Pan ◽  
Mei-Chi Chang ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Oral Cancer ◽  
Genetic Susceptibility ◽  
Molecular Mechanisms ◽  
Lysyl Oxidase ◽  
Oral Submucous Fibrosis ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Contributing Factors ◽  
Plasminogen Activator Inhibitor 1 ◽  
Submucous Fibrosis

Betel quid (BQ) chewing increased the risk of oral cancer and oral submucous fibrosis (OSMF), an oral premalignant disorder (OPMD) with malignant transformation potential. BQ components such as areca nut (AN), trauma by coarse AN fiber, catechin, copper, alkaloids, stimulated reactive oxygen species (ROS), inflammation and cytotoxicity are suggested to be the contributing factors. They may induce tissue inflammation, proliferation of fibroblasts and collagen deposition, myofibroblast differentiation and contraction, collagen cross-links and inhibit collagen phagocytosis, finally leading to the development of OSMF and oral cancer. These events are mediated by BQ components-induced changes of extracellular matrix (ECM) turnover via regulation of TGF-β1, plasminogen activator inhibitor-1 (PAI-1), cystatin, lysyl oxidase (LOX) and tissue inhibitors of metalloproteinases (TIMPs) and metalloproteinases (MMPs). Genetic susceptibility is also involved in these disease processes. Further understanding the molecular mechanisms of BQ-induced OSMF and oral cancer can be helpful for future disease prevention and treatment.

Consumption of areca quid, cigarettes, and alcohol related to the comorbidity of oral submucous fibrosis and oral cancer

2007 ◽  
Vol 104 (5) ◽  
pp. 647-652 ◽  
Author(s):  
Pei-Shan Ho ◽  
Yi-Hsin Yang ◽  
Tien-Yu Shieh ◽  
I.-Yueh Huang ◽  
Yun-Kwan Chen ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis

scholarly journals Cross-Cheek Dumbbell-Shaped Radial Forearm Flap for Simultaneous Correction of Oral Cancer and Submucous Fibrosis

2016 ◽  
Vol 9 (2) ◽  
pp. 162-165 ◽  
Author(s):  
Shreya Bhattacharya ◽  
Sivakumar Vidhyadharan ◽  
Krishnakumar Thankappan ◽  
Subramania Iyer
Keyword(s):  
Oral Cancer ◽  
Buccal Mucosa ◽  
Oral Submucous Fibrosis ◽  
The Other ◽  
Simultaneous Occurrence ◽  
Cancer Resection ◽  
Novel Technique ◽  
Radial Forearm ◽  
Submucous Fibrosis ◽  
Interincisor Distance

Simultaneous occurrence of oral submucous fibrosis along with carcinoma of the buccal mucosa is common. We report a novel technique of a single dumbbell-shaped, cross-cheek radial forearm free flap to repair bilateral defects caused by oral cancer resection on one side and the release of fibrosis on the other side in two patients. The dumbbell-shaped flap provided tissue for both the buccal mucosa defects and central released soft palate preventing fibrosis and reapproximation. The interincisor distance improved in both the patients.

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